Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing
Research Article
[키워드] accumulate
acute respiratory syndrome
Author
bioinformatics
clone
compared
competent
Complete
complex
consensus genome
coronavirus
coronavirus exoribonuclease
Coronaviruses
Critical
Culture
decrease
deep sequencing
demonstrated
Effect
Evolution
examined
experiment
Frequency
full-length genome
Genetic
Genome
genome replication
genome sequence
growth
Impact
in vitro
inactivation
increase in
Infidelity
lack
less
limit
mechanism
MOST
murine hepatitis virus
mutant
mutant virus
Mutation
nonstructural protein
nonstructural protein 14
nsp14
nsp14-ExoN
Nsps
passage
Pathogenesis
powerful tool
quasispecy
recognize
Replication
replication fidelity
required
resulting
Revealed
RNA genome
RNA genomes
RNA virus
SARS-coronavirus
SARS-CoV
sequence
stability
the Coronaviridae
to define
total population
unique
viral growth
viral replication
viral RNA genome
viral system
virus
virus
wild-type SARS-CoV
[DOI] 10.1371/journal.ppat.1000896 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000896 PMC 바로가기 [Article Type] Research Article