Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern SwedenRandomized Controlled Trial Published on 2021-12-042022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, SARS, [키워드] 1:1 95% CI addition convalescence convalescent plasma convalescent plasma group convalescent plasma treatment COVID-19 Desaturation died groups hospitalized COVID-19 patient hospitalized patient Inclusion IQR median median time no significant difference objective observational study Open-label oxygen saturation Oxygen therapy Oxygen treatment Patient plasma Primary outcome Randomized randomized controlled study receive Registered Result SARS-CoV2 Standard of care supplementary material survivor therapy Treatment Two patient viral infections with COVID-19 [DOI] 10.1186/s13104-021-05847-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Hemophagocytosis, hyper-inflammatory responses, and multiple organ damages in COVID-19-associated hyperferritinemiaClinical Trial Published on 2021-12-042022-10-04 Journal: Annals of Hematology [Category] MERS, SARS, 임상, [키워드] 95% CI age Analysis ARDS AUROC Characteristics chronic pulmonary disease COVID-19 COVID-19 patients cut-off value D-dimer death described Fever hemophagocytic lymphohistiocytosis hsCRP hyper-inflammation Hyper-inflammatory responses Hyperferritinemia IL-6 In-hospital death in-hospital mortality independent predictor indicated mechanical ventilator median much higher Multiple organ damage organ dysfunction Patient patients with AKI Prevalence Prognosis progressed proportion Retrospective study supplementary material Support [DOI] 10.1007/s00277-021-04735-1 PMC 바로가기 [Article Type] Clinical Trial
A multi-centre, randomized, double-blind, placebo-controlled clinical trial of the efficacy and safety of chloroquine phosphate, hydroxychloroquine sulphate and lopinavir/ritonavir for the treatment of COVID-19 in Lagos State: study protocol for a randomized controlled trial라고스 주에서 COVID-19 치료를 위한 인산클로로퀸, 황산히드록시클로로퀸 및 로피나비르/리토나비르의 효능과 안전성에 대한 다기관, 무작위, 이중 맹검, 위약 대조 임상 시험: 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-12-042022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 2019-nCoV 7-point ordinal scale acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added African allocation Analysis blinded caused China Chloroquine Chloroquine phosphate clinical clinical status clinician Clinicians coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Critical Data analysis develop disease double-blind drug effective Efficacy Efficacy and safety Health Health Organization Hydroxychloroquine hydroxychloroquine sulphate identity intention-to-treat Intervention Lago Lagos lead Lopinavir Lopinavir/ritonavir management Mathematical modelling measure Ministry of Health National Nigeria Ordinal Scale outcome measures Pan pandemic participant Participants Patient patients with COVID-19 phosphate placebo-controlled placebo-controlled clinical trial Primary outcome R software Randomized Randomized controlled trial Research respiratory Ritonavir SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity severity of illness Standard of care Standard therapy state statistical analysis Study protocol sulphate supplementary material team the disease treat Treatment Trial Trial registration World Health Organization Wuhan [DOI] 10.1186/s13063-021-05675-x PMC 바로가기 [Article Type] Study Protocol
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19내피 글리코칼릭스 분해의 지표인 신데칸-1, 코로나19로 중환자실에 입원한 환자의 결과 예측Research Article Published on 2021-12-032022-09-10 Journal: Molecular Medicine [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Coagulopathy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Degradation demographic destruction develop endothelial endothelial damage Endothelial glycocalyx examined feasibility glycocalyx greater ICU increased mortality indicated Inflammation inflammatory reactions intensive care intensive care unit interleukin interleukin-6 investigated Kaplan–Meier survival analysis laboratory data log-rank test marker median Mortality non-survivor not significantly different outcome Patient Potential treatment predict progression Protecting Result serum severity of COVID-19 significantly higher supplementary material survival survival analysis survivor Survivors syndecan Syndecan-1 thrombomodulin Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α two group Variation with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s10020-021-00412-1 PMC 바로가기 [Article Type] Research Article
The impact of natural disasters on the spread of COVID-19: a geospatial, agent-based epidemiology modelResearch Published on 2021-12-032022-10-29 Journal: Theoretical Biology & Medical Modelling [Category] COVID-19, [키워드] agent-based model Campania co-occurrence COVID-19 COVID-19 outbreak disease epidemiological Epidemiology evaluate evaluated fatality global pandemic Health increase increase in Infection Infectious disease Italy majority Natural disaster Occurrence outcome Result Spread spread of COVID-19 supplementary material the median the timing widespread [DOI] 10.1186/s12976-021-00151-0 PMC 바로가기 [Article Type] Research
Healthcare professionals’ perceptions of impacts of the Covid-19-pandemic on outpatient care in rural areas: a qualitative studyResearch Published on 2021-12-022022-10-28 Journal: BMC health services research [Category] COVID-19, SARS, [키워드] adopted analysed Analysis Cardiologists Care changes in chronic collected condition conditions conducted consequence content analysis Course COVID-19 pandemic disease Effect Effects examined family Family physicians female Germany hcp Health policy healthcare Healthcare professional Healthcare provision Healthcare system hospital Impact impacts insight lack maintain majority measure outcome outcomes Outpatient pandemic Patient care patients physician Physicians Psychological well-being recorded recruited reduce Result secondary care supplementary material Support tension transcribed [DOI] 10.1186/s12913-021-07261-y PMC 바로가기 [Article Type] Research
Semen parameters in men recovered from COVID-19: a systematic review and meta-analysisReview Published on 2021-12-022022-10-29 Journal: Middle East Fertility Society Journal [Category] COVID-19, [키워드] 95% CI Affect age article Concentration confidence interval consequence Control COVID-19 database disease eligibility eligible evaluated females heterogeneity high risk Hormones infertility less Luteinizing Hormone male Male sex mean difference mechanism men Meta-analysis novel beta-coronavirus observational studies parameter participant reported SARS-CoV-2 Semen serum Seven sex hormone Sex hormones Standard deviation subject suffered supplementary material systematic review Volume was performed were assessed [DOI] 10.1186/s43043-021-00089-w PMC 바로가기 [Article Type] Review
A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocolCOVID-19(ReCOVer) 이후 심각한 감염 후 피로를 표적으로 하는 인지 행동 요법인 Fit after COVID의 효능을 테스트하는 무작위 대조 시험: 연구 프로토콜Study Protocol Published on 2021-12-022022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 acute phase addition behavioural benefit both groups Care CBT changes in checklist cognitive Cognitive behavioural therapy conditions consequence contribute coronavirus disease Coronavirus disease 2019 COVID COVID-19 determine effective Efficacy eligible fatigue fatigued Follow-up follow-up assessment follow-up assessments Health in both group individual infection with SARS-CoV-2 Internet therapy Intervention lead Long COVID Long-Haul COVID-19 Fatigue Long-term follow-up multicentre Netherland other conditions participant PASC performed physical Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Post-COVID-19 syndrome prevalent Primary outcome problem problems proportion protocol randomisation randomised randomised controlled trial RCT reduce reducing referred to SARS-CoV-2 SARS-COV-2 infection Secondary objective Secondary objectives severe fatigue severity shown significantly lower strength Study protocol subgroup of patients supplementary material Symptom Symptoms treat Treatment trial testing [DOI] 10.1186/s13063-021-05569-y PMC 바로가기 [Article Type] Study Protocol
COVID-19 pandemic modifies temperature and heat-related illness ambulance transport association in Japan: a nationwide observational studyObservational Study Published on 2021-12-022022-10-04 Journal: Environmental Health [Category] 임상, [키워드] Ambulance transport approach association changes contrary covariate COVID-19 COVID-19 pandemic dimensions Effect modification Evidence examined Heat-related illness illness implication Intervention Japan Japanese Lag Meta-analysis modify pandemic Pandemics physical provide random-effect reduced reduction Result risk stratified subsequent supplementary material temperature Transport was recorded [DOI] 10.1186/s12940-021-00808-w PMC 바로가기 [Article Type] Observational Study
Finnish late adolescents’ physical activity during COVID-19 spring 2020 lockdownResearch Published on 2021-12-012022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] Analysis boost change closure club COVID-19 Cycling Diseases distribution effective strategy Factor female finding Finnish Frequency Home-gym identify immune system less lockdown Logistic regression male National Non-communicable disease Organised sport Participation performed physical physical activity physical activity level physical education Prevent reduced reported Result Schools statistically significant supplementary material walking [DOI] 10.1186/s12889-021-12263-w PMC 바로가기 [Article Type] Research