COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary FactorsCOVID-19 : SARS-COV-2의 다중 대포 전파는 폐 인자에 의해 구동됩니다.Article Published on 2021-12-262022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] ABL1 ALP ALT alveolar damage association AST average Brain cause cohort of patients COVID-19 COVID-19 patient COVID-19 patients CPK DAD died Diffuse alveolar damage dissemination dysfunction Factor FFPE Frequency heart heart failure Isolated kidney kidneys LDH liver lung Lungs Lymph node lymph nodes mono multi-organ dissemination multi-organ failure multiplex real-time polymerase chain reaction Myocardium organ outcome Pathogenesis proliferative pulmonary qPCR ranged Research risk of death SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load Serum level spleen the SARS-CoV-2 Viral Viral load [DOI] 10.3390/v14010039 PMC 바로가기 [Article Type] Article
Five reasons COVID-19 is less severe in younger age-groupsCommentary Published on 2021-12-262022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] antagonistic antagonistic pleiotropy cause Community COVID-19 crowd diseases explained immune system infection with SARS-CoV-2 less life history life history theory Older pleiotropic progression respond SARS-CoV-2 severity of COVID-19 T cells the timing [DOI] 10.1093/emph/eoaa050 PMC 바로가기 [Article Type] Commentary
Secondary Impact of COVID-19 Pandemic on People with Parkinson’s Disease—Results of a Polish Online SurveyArticle Published on 2021-12-262022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Affect Anxiety cause Contact COVID-19 COVID-19 pandemic Deterioration Factor greater Impact Isolation medication Mental motor symptom not affect over pandemic Parkinson’s disease Parkinson’s disease participant problem Quality of life questionnaire reduced reduction remained reported secondary Stress Subjective survey Symptoms worsening [DOI] 10.3390/brainsci12010026 PMC 바로가기 [Article Type] Article
SARS-CoV-2 challenge studies: ethics and risk minimisationCurrent Controversy Published on 2021-12-252022-10-30 Journal: Journal of medical ethics [Category] COVID-19, [키워드] accelerate approach assessment cause clinical implication clinical trials COVID-19 COVID-19 incidence criteria Critical develop effective effective vaccine epidemiological Ethics evaluate exceptional global public health healthy volunteer human infection infecting pathway raised Recognition Research Research Ethics risk SARS-CoV-2 scientific research Treatment virus [DOI] 10.1136/medethics-2020-106504 PMC 바로가기 [Article Type] Current Controversy
SARS-CoV-2 Infection and Pancreatic β Cell FailureReview Published on 2021-12-242022-10-28 Journal: Biology [Category] COVID-19, [키워드] β cell accumulating acute respiratory syndrome association cause Cell contribute coronavirus coronavirus disease COVID-19 damaged diabete diabetes Diabetes Mellitus Evidence failure indirect effect induce Infection multiple organ dysfunction pancrea pancreas pancreatic Pathogenesis Patient patients with COVID-19 precipitated reported Research risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 simple study groups target virus [DOI] 10.3390/biology11010022 PMC 바로가기 [Article Type] Review
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
mTOR kinase is a therapeutic target for respiratory syncytial virus and coronavirusesArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] absence antiviral agent antiviral drugs approach approaches cause cellular children coronavirus described disease effective effective antiviral treatment Factors function Gene Expression Host Infant Infection Intervention kinase life-threatening Lower respiratory tract Mild Molecular biology mRNA mTOR signaling progeny Protein reduce respiratory respiratory pathogen respiratory syncytial virus respiratory tract infection RSV shown Symptom therapeutic target Transcription upper respiratory tract Vaccine Viral host response viral infection viral infections viral pathogenesis Viral resistance virus while [DOI] 10.1038/s41598-021-03814-7 PMC 바로가기 [Article Type] Article
The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug DesignMicrobiology Published on 2021-12-242022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] alleviate Apoptosis ATF6 autophagy cause Cell complex interplay coronavirus Coronavirus infection Coronavirus replication cytoplasm drug drug target drug targets Endoplasmic reticulum endoplasmic reticulum stress ER stress homeostasis host innate immunity Human Infection innate immune response knowledge microRNA modulate occur pathogen Pathogenesis regulate Replication reported response role signaling pathways threat unfolded protein response unfolded protein response (UPR) UPR [DOI] 10.3389/fmicb.2021.808593 PMC 바로가기 [Article Type] Microbiology
Development of a prediction score for in-hospital mortality in COVID-19 patients with acute kidney injury: a machine learning approachArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] SARS, 치료법, [키워드] 95% CI Accuracy acute kidney AKI approach assist build can be used category cause characteristic Characteristics coefficient Comorbidity condition COVID-19 COVID-19 patient cross-sectional defined develop development Diagnosis disease severity Elastic evaluated healthcare worker hospitalized COVID-19 patient in-hospital mortality Intensive KDIGO Kidney diseases Kidney injury Laboratory Latin America multicentre Predictive predictor variable prognostic prospective cohort study registry resource Risk factors validation cohort were used with COVID-19 [DOI] 10.1038/s41598-021-03894-5 PMC 바로가기 [Article Type] Article
COVID-19 Prognostic Models: A Pro-con Debate for Machine Learning vs. Traditional StatisticsDigital Health Published on 2021-12-232022-10-31 Journal: Frontiers in Digital Health [Category] COVID-19, [키워드] artificial intelligence cause classical clinician coronavirus COVID-19 COVID-19 pandemic Critical care datasets debate diagnostic epidemiological healthcare IMPROVE increasingly individual Linear regression machine learning mathematical outcomes prognostic programming SARS-CoV-2 virus significantly Statistics systematic review Topic Traditional virus [DOI] 10.3389/fdgth.2021.637944 PMC 바로가기 [Article Type] Digital Health