SARS-CoV-2 Detection for Diagnosis Purposes in the Setting of a Molecular Biology Research LabArticle Published on 2020-08-182022-10-30 Journal: Methods and Protocols [Category] COVID-19, [키워드] amplification Analysis Asymptomatic carrier automated Biology clinical sample composed contagious COVID-19 COVID-19 case Critical detection Diagnosis diagnostic false-negative growth heterogeneous Isolation lab lack Molecular biology nucleic acid extraction PCR platform protocol public health systems reagent Research researchers reverse transcription RTqPCR SARS-CoV-2 SARS-CoV-2 detection setting specimens the SARS-CoV-2 virus viral nucleic acids [DOI] 10.3390/mps3030059 PMC 바로가기 [Article Type] Article
Putative SARS-CoV-2 M pro Inhibitors from an In-House Library of Natural and Nature-Inspired Products: A Virtual Screening and Molecular Docking StudyArticle Published on 2020-08-172022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] acute respiratory syndrome approach AutoDock binding pocket blind candidate catalytic dyad complexes composed Compound compounds contagious coronavirus COVID-19 diffusion docking drug target enzyme experiment global pandemic heterogeneous Host imperative in viral Infectious diseases Interaction library life-threatening M pro molecular molecular docking Molecular modeling natural natural products library Novel coronavirus performed Probability protease Protein Replication Research SARS-CoV-2 screened Screening selected Small molecules stability therapy Virtual screening virus was tested [DOI] 10.3390/molecules25163745 PMC 바로가기 [Article Type] Article
The Contagion of Sentiments during the COVID-19 Pandemic Crisis: The Case of Isolation in SpainArticle Published on 2020-08-142022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, [키워드] affected affective Analysis analyzed approach caused confinement contagion of emotions contagious contribute COVID-19 COVID-19 disease COVID-19 pandemic ecosystem emergency response emotional event Evidence Health Health crisis implication Isolation management measure media pandemic provide sentiment analysis Spain [DOI] 10.3390/ijerph17165918 PMC 바로가기 [Article Type] Article
Modeling the Onset of Symptoms of COVID-19Public Health Published on 2020-08-132022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] catastrophic clinical observation Clinical practice Cluster Contact tracing contagious cough COVID-19 COVID-19 case COVID-19 patient COVID-19 patients diarrhea disease Diseases Fever gastrointestinal symptoms help illnesses Influenza information initiate Local Markov MERS Model modeling nausea/vomiting observé occur Occurrence Onset other diseases outbreak pandemic Patient predict Probability Process professional progression Region respiratory diseases spring stochastic Support Symptom Symptoms the disease these symptom viral disease [DOI] 10.3389/fpubh.2020.00473 PMC 바로가기 [Article Type] Public Health
The status and high risk factors of severe psychological distress in migraine patients during nCOV-2019 outbreak in Southwest China: a cross-sectional studyResearch Article Published on 2020-08-122022-10-29 Journal: The Journal of Headache and Pain [Category] COVID-19, MERS, [키워드] 95%CI aerosol age China collected Contact contagious Control coronavirus disease COVID-19 cross-sectional distress effective enrolled Factor Frequency Healthcare professional healthy control high risk identify Kessler 6-item psychological distress scale lack mental health migraine multivariate logistic regression NEUROLOGY objective Odds ratio outbreak Outbreaks Panic Patient patients Potential prevalent Psychological distress public health reducing Result risk factor Severe psychological distress significantly higher treated Treatment West [DOI] 10.1186/s10194-020-01168-5 PMC 바로가기 [Article Type] Research Article
A COVID‐19 human viral challenge model. Learning from experienceInvited Review Article Published on 2020-08-122022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] COVID-19, MERS, SARS, [키워드] accelerate clinical trial contagious Controlled human infection model COVID‐19 COVID‐19 determine develop effective Efficacy evaluate experience help human infection human viral challenge model infect Infection learning pathogenic potential benefit potential therapy respiratory syncytial virus RSV SARS‐CoV‐2 virus SARS‐CoV‐19 the vaccine Treatment Vaccine viral challenge virus volunteers [DOI] 10.1111/irv.12797 PMC 바로가기 [Article Type] Invited Review Article
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure historyResearch Article Published on 2020-08-122022-10-28 Journal: Virulence [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected appear China Contact Contact tracing contagious coronavirus coronavirus disease Course COVID-19 disease disease onset dissemination face masking feature Hospital stay Incubation period Inpatient Intervention lowest lymphocyte lymphocytopenia Older age pandemic Patient patients reduced risk factor SARS-CoV-2 severity social distancing Spread symptomatic and asymptomatic the disease the patient transmissions transmitted underlying condition unique virulence Wuhan [DOI] 10.1080/21505594.2020.1802870 PMC 바로가기 [Article Type] Research Article
Care for Critical Ill Patients With COVID-19: Establishment of a Temporary Intensive Care Unit in an Isolated HospitalMedicine Published on 2020-08-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Care China confirmed case contagious COVID-19 COVID-19 patient Critical care Critically ill disease Healthcare systems hospital ICU ICUs Ill increase in intensive care unit Isolated management Medical resources progression required severe severe cases spread of COVID-19 temporary the disease Wuhan [DOI] 10.3389/fmed.2020.00519 PMC 바로가기 [Article Type] Medicine
Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19Molecular Biosciences Published on 2020-08-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 receptor Activation acute lung injury Against airway epithelial cells antibody appear approach can be used caused cell receptor cellular cleavability complement contagious coronavirus coronavirus disease correlated COVID-19 cytokine Cytokine storm disease disease severity docking drug candidate early phase Effect enzyme excessive inflammatory response expressed expression Factor followed by help highlight highly pathogenic host cells Host immune response host tropism humans IL-6 immune dysregulation immunomodulator immunomodulators inflammatory mediator Innate immunity Interaction involved Lung inflammation mannose-binding lectin mechanism MERS-CoV molecular novel Occurrence pathogenic Proinflammatory cytokine Protein proteolytic recombinant Research respiratory epithelial cell Respiratory tract infections S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection secreted spike Strategy targeted therapy Therapeutic approach TMPRSS2 understanding Vaccine viral infection Viral pneumonia virulence virus with COVID-19 [DOI] 10.3389/fmolb.2020.00196 PMC 바로가기 [Article Type] Molecular Biosciences
The Characterization of chIFITMs in Avian Coronavirus Infection In Vivo, Ex Vivo and In VitroArticle Published on 2020-08-102022-10-31 Journal: Genes [Category] Coronavirus, MERS, [키워드] activated Affect avian infectious bronchitis virus (IBV) cellular characterization contagious coronavirus days post-infection enveloped RNA virus Ex vivo Host IBV IBV infection IFITM in vitro in vivo Infection Infectious Bronchitis Virus innate response interferon-inducible transmembrane (IFITM) proteins kidney Mortality mRNA expression nonpathogenic pathogenic Post-infection Protein Replication reproductive Respiratory illness respiratory pathogen restrict restriction factor resulting strain transmembrane upregulation viral infection viral pathogens [DOI] 10.3390/genes11080918 PMC 바로가기 [Article Type] Article