Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents무증상 또는 경증의 증상이 있는 SARS-CoV-2 감염은 소아 및 청소년에서 지속적인 중화 항체 반응을 유발합니다Research Article Published on 2021-09-082022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] acute infection Adaptive immunity All participants Antibody Response Antibody responses Asymptomatic children comparable contribute detectable elicit evaluated generate humoral immune response humoral immune responses IgA IgG IgM immune response immune responses immunology Infectious disease Mild Neutralizing activity Neutralizing antibody response Participants populations question Reinfection robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection sera Spread strength symptomatic infection symptomatic SARS-CoV-2 infection virus-neutralizing [DOI] 10.1172/jci.insight.150909 PMC 바로가기 [Article Type] Research Article
Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in MiceMicrobiology Published on 2021-09-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] BALB/c BALB/c mice binding candidate vaccine CD4 CD8 Cell cellular immunity clinical testing coding sequence Consensus coronavirus disease COVID-19 cytokine production demonstrated DNA DNA vaccine dose effective elicit elicited ENhance full-length S global pandemic glycoprotein humoral IFN-γ IgG IgG antibodies IgG antibody IL-2 immune response immune responses immunization immunogenic in viral induce injection intramuscular long-lasting Measures memory memory T mice mouse model NAb neutralizing antibody Pathogenesis plasmid DNA preclinical (in vivo) studies Prophylactic Protective protective immunity Protein response robust Safe SARS-CoV-2 significant level significantly spike (S) glycoprotein synthetic T cell Th1 the vaccine therapeutic TNF Vaccine was tested [DOI] 10.3389/fmicb.2021.727455 PMC 바로가기 [Article Type] Microbiology
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variantsSARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향Research Article Published on 2021-09-072022-09-10 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used [DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article
Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection새로운 바이러스 유사 나노 입자 백신은 SARS-CoV-2 감염으로부터 동물 모델을 효과적으로 보호합니다Research Article Published on 2021-09-072022-09-10 Journal: PLoS Pathogens [Category] 변종, 신약개발, 진단, [키워드] animal model blocked boost cell entry Clinical sign Clinical signs contribute coronavirus COVID-19 pandemic curtail develop domain effective Effectiveness Efficacy elicit FIVE help host receptor human population immune response immune responses Immunity immunized mice inhibited lack mice mRNA mRNA-based neutralized Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response novel pathological change pathological changes PROTECT Protein Protein-based vaccines provide RBDs Receptor-binding domain recombinant reducing Safe SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variants Spread Strains study period subunit vaccines the cell the RBD Vaccine vaccine candidate variant variants variants of SARS-CoV-2 variety Viral viral vector-based VLP [DOI] 10.1371/journal.ppat.1009897 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial아데노바이러스 벡터화 및 mRNA COVID-19 백신(Com-COV)을 사용한 이종 대 상동 프라임-부스트 일정의 안전성 및 면역원성: 단일 맹검, 무작위, 비열등성 시험Clinical Trial Published on 2021-09-042022-09-11 Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상, 진단, [키워드] (ChAdOx1 nCoV-19 Administered age anti-Spike IgG approved assigned AstraZeneca baseline blood test blood tests BNT BNT162b2 boost ChAd ChAdOx1 ChAdOx1 nCoV-19 Cohort Comorbidity comparison Concentration COVID-19 COVID-19 disease COVID-19 vaccine COVID-19 vaccines criteria dose Efficacy eight eligible eligible participant Eligible participants ELISA enrolled evaluate facilitate female participant force geometric mean geometric mean concentration geometric mean ratio GMR greater groups Heterologous heterologous prime-boost heterologous schedule heterologous schedules homologous homologous schedule hospitalisation immune immune responses immunisation immunogenicity immunology inferiority ISRCTN laboratory confirmation limit majority mRNA mRNA vaccine non-inferiority non-inferiority trial occurred Older participant per-protocol population Pfizer-BioNTech primary analysis primary endpoint prime-boost interval prime-boost intervals randomised Randomly reactogenic reactogenicity receive receiving recipient recruited referred to regimen Registered reported Safety safety analyses safety analysis SARS-CoV-2 anti-spike IgG SARS-COV-2 infection Serious Adverse Event seronegative serum single-blind subset Support Task Force the SARS-CoV-2 the vaccine These data Trial vaccination Vaccine Vaccines vectored vaccine was done [DOI] 10.1016/S0140-6736(21)01694-9 PMC 바로가기 [Article Type] Clinical Trial
Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasiaResearch Published on 2021-09-032022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, SARS, [키워드] abrogated affected age antibody appear Chronic fatigue consequence control group control subject coronavirus disease Coronavirus infection Course COVID-19 COVID-19 symptom enrolled epithelial fatigue genetic disorder Hair loss HED Hypohidrotic ectodermal dysplasia immune responses Increased increased risk individual Infection Measures Mild moderate pathway Patient patients Postinfectious recovering from COVID-19 required Result risk SARS-CoV-2 SARS-COV-2 infection severe fatigue Spike protein suffered supplementary material susceptible the SARS-CoV-2 vaccination against COVID-19 [DOI] 10.1186/s13023-021-02011-z PMC 바로가기 [Article Type] Research
Relaxing restrictions at the pace of vaccination increases freedom and guards against further COVID-19 waves예방 접종 속도에 따라 편안한 제한은 자유를 증가시킵니다.Research Article Published on 2021-09-022022-09-10 Journal: PLoS Computational Biology [Category] 변종, [키워드] addition age analyzed approach average average age benefit children compartmental model Contact Contagion contagious country COVID-19 COVID-19 pandemic COVID-19 vaccination curated death Deceased decrease demographics determine driver Drivers epidemiological European events example Face masks facilitate Factor FIVE Healthcare systems high mortality highlight hygiene ICU ICU patient ICU Patients immune responses Immunity Impact increase increase in Infection Intervention Keeping lifted Local maintain mass vaccination Mild moderate morbidity Mortality observé offer pace Post-infection Prevent preventive measure preventive measures quantified Quantitative reduce reduce mortality reducing reduction reduction in selected Seroprevalence significantly speed Strategy summer susceptibility susceptible Taking union vaccination Vaccinations Vaccine variants Viral viral spread virus variant [DOI] 10.1371/journal.pcbi.1009288 PMC 바로가기 [Article Type] Research Article
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응Research Article Published on 2021-09-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘, [키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses [DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approachCOVID-19 발병 기전에서 예측된 SARS-CoV-2 miRNA의 역할 해독: 생물정보학 접근Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Apoptosis apoptotic pathway apoptotic pathways approach bioinformatics computational tool computational tools Coronavirus-2 COVID-19 COVID-19 pathogenesis dataset deregulated down-regulated down-regulated gene e genes enriched pathways function functional enrichment Genes global pandemic Host immune immune responses immune system infected cells infections influence immune responses involved KEGG pathway analysis microRNA miRNA miRNAs modulating molecular mechanism p53 Pathogenesis pathogenicity pathway predicted progression provide regulated Repository SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 miRNA SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling significantly survival target the SARS-CoV-2 transcriptomic profile up-regulated viral miRNA viral miRNAs viral pathogenesis virus [DOI] 10.1016/j.compbiomed.2021.104669 PMC 바로가기 [Article Type] Article