A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation
사르데냐인의 염증 표지자 수준에 대한 게놈 전체의 연관성 스캔은 복잡한 조절을 뒷받침하는 연관성을 보여줍니다
Research Article
[키워드] ABO gene
AIRE
APOC-I
approach
association
associations
Author
autosomal
C-reactive protein
CADM3
CCR2
Cohort
common disease
complex
conducted
CR1
CRP
CRP gene
damaged cells
DARC
detect
different
different diseases
Effects
erythrocyte sedimentation
erythrocyte sedimentation rate
ESR
Evidence
Factor
found
functional
Gene
genetic determinant
genetic determinants
Genetic variant
genetic variants
genome-wide association scan
Genome-wide association scans
genome-wide significant
genotyped
GWAS
HBB
Health
help
High-sensitivity C-reactive protein
highlight
HNF1A
hsCRP
ICOSLG
identifying
IL-6
IL-6R gene
ImmunoChip
implicated
IMPROVE
included
independent
individual
individuals
Inflammation
inflammation erythrocyte sedimentation rate
Inflammatory biomarker
interleukin
interleukin-6
knowledge
large cohort
led to
Level
loci
MCP-1
mechanism
MetaboChip custom arrays
molecular mechanism
molecular mechanisms
monocyte
monocyte chemotactic protein-1
novel
organism
performed
power
pro-inflammatory molecule
pro-inflammatory molecules
Protective
Protein
provided
QTLs
Quantitative
quantitative traits
receptor
Regulation
replicated
robust
rs113459440
rs11829037
rs1205
rs12075
rs12567990
rs17141006
rs225918
rs3026968
rs3093077
rs3845624
rs4129267
rs4420638
rs4910472
rs657152
Sardinia
Sardinian
sedimentation rate
selected
SNP
SPPL3
TMEM57
UCN119B
UNC119B
variant
X chromosome SNP
[DOI] 10.1371/journal.pgen.1002480 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002480 PMC 바로가기 [Article Type] Research Article