Peripheral blood
[대역어] 말초 혈액
[용어속성] Term
[용어속성] Term
Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens
Research Article
[키워드] Antigen
Blood
blood monocyte
Cell
cells
demonstrated
disseminate
dissemination
IBV
in vitro
in vivo
Infectious Bronchitis Virus
inoculated
internal organ
kidney
kidney infection
liver
Lungs
M41
mononuclear cell
mucosa
penetrate
Peripheral blood
plasma
positive cell
post inoculation
Replication
replication kinetics
respiratory tract
secretion
spleen
strain
Trachea
tracheal
Viral RNA
Viremia
virus
[DOI] 10.1186/s13567-016-0354-9 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/s13567-016-0354-9 PMC 바로가기 [Article Type] Research Article
Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response
대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다
Research Article
[키워드] absence
ACVRL1
analyzed
animals
Antigen
autosomal dominant
autosomal dominant disorder
auxiliary
Bacteria
balance
blood monocyte
blood monocytes
C57BL/6
cell line
characterized
conditions
contribute
deficiency
described
develop
differentiation
disorder
dominant
dysplasia
Endoglin
endotoxin
ENG
explain
expressed
expression
foci
function
help
hemorrhage
hemorrhages
Hereditary
Hereditary hemorrhagic telangiectasia
homeostasis
human cell
human macrophages
immune
immune response
Impaired
in vitro
in vivo
increased survival
Infection
infection rate
Infectious disease
Infectious diseases
Inflammation
internal organs
knock-out
Laboratory
leukemic
leukemic cell
Lineage
Macrophage
macrophages
malformation
mice
monocyte
monocyte-macrophage
Monocytes
Mortality
mouse macrophages
multisystemic
patients
Peripheral blood
peripheral blood monocytes
peritoneal macrophage
peritoneal macrophages
peritonitis
Phagocytic activity
predisposition
Prevalence
rare disease
receptor
recruited
Rendu-Osler-Weber syndrome
response
responsible
show
Signaling
surface antigen
syndrome
target gene
Target genes
TGF-β
TGF-β1
transmembrane protein
triggered
type I
up-regulation
Vascular
vessel wall
was reduced
Weber syndrome
wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway
류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다
Research Article
[키워드] activated
After
allele
Analysis
approved drug
Arthritis
association
Author
B cells
B lymphocyte
B lymphocytes
Biology
can be used
CD19+
CD40
CD40 ligand
CD40 signaling
Cell
cell line
chemical compounds
clinical care
coding
Combination
complex
Compound
consequence
controls
correlation
counter
deep sequencing
develop
disease
drug
Drug discovery
drugs
effort
eQTL
ExoN
exonic
explain
expression
finding
Follow-up
gain-of-function
Genetic
genetic findings
Genome-wide association studies
Genome-wide association study
genotyping
guide
GWAS
healthy control
homozygous
Human
Human genetics
identify
implicated
increase
individuals
Infection
Inflammation
inhibit
inhibitor
loci
locus
lymphocyte
Lymphocytes
mononuclear cell
mononuclear cells
mouse
NF-kB
NF-κB
NF-κB signaling
non-risk allele
observé
p65
pathway
Patient
Peripheral blood
Peripheral blood mononuclear cells
Phosphorylation
Protein
Quantitative
RA
RELA
reporter
retroviral
Rheumatoid
rheumatoid arthritis
risk
risk allele
Screen
second
Sequencing
seropositive
Signaling
single SNP
small molecule
Small molecules
small-molecule screen
subject
subunit
therapy
trait
traits
transcription factor
treat
variant
while
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases
기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다
Research Article
[키워드] 358Ala
Abdominal aortic aneurysm
affecting
allele
analyzed
aortic aneurysm
approach
Arthritis
Asp358Ala
association
Asthma
Atrial fibrillation
Author
balance
benefit
Cambridge BioResource
causal variant
CD4+ T cell
CD4+ T cells
CHD
Chronic diseases
circulating
cleavage
clinical trial
clinical trials
common diseases
complex
complex diseases
Concentration
Control
copy
Coronary heart disease
Critical
cytokine
diabete
diabetes
etiology
Evidence
expression
functional
Genetic
genetic association
Genetic variation
heart disease
human disease
identify
IL-6
IL-6 receptor
IL-6 signaling
IL-6R
IL-6R signaling
IL-6R signaling pathway
IL6R
Immune cell
immune cells
impairment
implicated
implication
increase
increase in
independent
Inflammatory
Inflammatory responses
influence
interleukin
interleukin-6
isoform
mechanism
membrane-bound
molecular mechanism
monocyte
Monocytes
mononuclear cell
mononuclear cells
Non-synonymous
nucleotide
Patient
PBMCs
Peripheral blood
Peripheral blood mononuclear cells
Phosphorylation
polymorphism
Population
protein level
protein levels
RA
reduce
reduced
reduction
regulated
Regulation
rheumatoid arthritis
risk
rs2228145
Signaling
sIL-6R
single nucleotide
Single nucleotide polymorphism
soluble IL-6R
Stat1
STAT3
Stimulation
suggested
surface expression
surface receptor
susceptibility
T cells
T1D
therapeutic intervention
therapy
These data
Transcription
transcription factor
transcription factors
translate
Treatment response
Type 1 diabetes
variant
Variation
Volunteer
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus
MicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다
Research Article
[키워드] 3′ UTR
3′UTR
activate
affecting
African Americans
allelic
Americans
Antigen
Asian
Asians
association
Author
Autoimmune
Autoimmune disease
binding
binding site
C allele
C-allele
carriers
conducted
contributed
Control
copy number
correlated
debilitating autoimmune disease
decrease
Degradation
dose-dependent
downregulated
driven by
duplication
elevated
Epigenetic
European
Evidence
exhibited
exhibiting
expression
functional
G allele
G-allele
genomic
greater
HEK-293
HEK-293 cell
HEK-293 cells
Human
identify
IFN
IFN-α pathway
increased risk
independent
individual
innate immune activation
lack
led to
luciferase
luciferase activity
Lupus
lupus erythematosus
lupus-like disease
mechanism
microRNA
microRNA-3148
microRNA–gene
miR-3148
modulation
mononuclear cell
mononuclear cells
mRNA
murine model
non-risk allele
non-risk C allele
nuclear
nucleotide
Odds ratio
overexpression
Pathways
PBMC
PBMCs
Peripheral blood
Peripheral blood mononuclear cells
polymorphism
predicted
promote
Protein
protein level
provide
R 2
reduction
regulate
Regulatory
reported
reporter
reporter gene
respond
resulting
risk
sequence
signaling pathways
significantly increased
single nucleotide
Single nucleotide polymorphism
SLE
SLE patient
SLE patients
SNP
subject
susceptibility
systemic
systemic lupus erythematosus
the strongest
These data
TLR7
TLR7 gene
TLR7 mRNA
TLR7-TLR8 region
TLR7/8/9
TLRs
Toll-like receptor
toll-like receptor 7
Toll-like receptors
transcript
transcript level
transcripts
transfected cells
type I interferon
UTR
variant
Variation
while
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria
A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성
Research Article
[키워드] 95% confidence interval
A allele
a major
activated
affected
allele
Analysis
Anemia
Apoptosis
applied
assigned
association
Author
carried
Case-control
caused
CD69
Cell
cell surface receptor
cerebral malaria
childhood
children
Community
compared
complex interplay
complications
Control
Donor
ENCODE
Endemic
Express
expression
FACS analysis
FAS
fatality
found
functional
Genetic variant
genetic variants
genetics
Health
healthy individual
help
heterozygote
homozygote
homozygous
Human
Human genetics
immune regulation
immune response
immune responses
increased expression
individual
Infection
investigated
involved
life-threatening
locus
lymphocyte
Lymphocytes
malaria
molecule
mononuclear cell
mononuclear cells
naïve
nucleotide
Occurrence
Odds ratio
outcome
Pediatric case
Peripheral blood
Peripheral blood mononuclear cells
phenotypic
Plasmodium
Plasmodium falciparum
predisposition
programmed cell death
promoter
promoter region
proportion
PROTECT
Protective
protective immune response
Replication
risk
severe
severe malaria
significantly
significantly higher
Single nucleotide variant
sub-Saharan Africa
subgroup
surface receptor
susceptibility
susceptible
syndrome
T-lymphocyte
the disease
Transmission dynamics
variant
West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
Research Article
[키워드] 2003
acute respiratory syndrome
approach
Asia
biological systems
Blood
caused
change
changes in
Clinical severity
Clustering
Control
controls
coronavirus
correlated
disease
distress
Epidemic
expression profile
Gene
Gene Expression
Genes
Host
human disease
immunopathological damage
Innate immunity
International
involved
mortality rate
Novel coronavirus
pathophysiology
Patient
Peripheral blood
Pulmonary infection
recovering patient
regulated
reported
Result
SARS patient
SARS patients
SARS-CoV
several gene
severe
severity
significantly
Spread
upregulated
while
World Health Organization
[DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection
Research Article
[키워드] 24 hours
activated
acute respiratory syndrome
Analysis
Antibody binding
array
assay
Blood
cell activation
change
chemokine
clinical feature
Coagulation
coronavirus
CoV
cytokine production
described
disease pathology
distress
donors
examined
Gene Expression
healthy donor
high-density
host response
IL17
IL8
immune response
in vitro
indicated
infecting
Infection
infiltration
inhibited
inoculated
interstitial
interstitial inflammation
lung trafficking
lymphopenia
mechanism
molecular basis
monocyte-macrophage
mononuclear cell
Pathogenesis
pathology
pathway
PBMC
PBMCs
Peripheral blood
provide
Quantitative assays
Result
SARS Coronavirus
SARS patient
SARS-CoV
Signaling
specific antibody
the disease
TLR9
upregulation
viral replication
viral replication kinetics
[DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article