Tocilizumab – Page 57 – Communicable Diseases Research

COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment

토실리주맙 치료 후 실어증이 해소되는 COVID-19 관련 뇌병증

Case Reports

Published on 2020-12-152022-09-12
Journal: Journal of neuroimmunology [Category] MERS, SARS, 진단, 치료법,

Compassionate Use of Tocilizumab for Treatment of SARS-CoV-2 Pneumonia

SARS-CoV-2 폐렴 치료를 위한 토실리주맙의 자비로운 사용

Article

Published on 2020-12-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 신약개발, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse adverse events anti-IL-6R antigen receptor appear approved benefit C-reactive protein C-reactive protein (CRP chimeric antigen receptor clinical and laboratory parameters clinical trials compassionate use coronavirus COVID-19 CRP cytokine Cytokine storm death Decline declines dose drug Drug administration Efficacy event examined Follow-up food Food and Drug Administration hospitalized patient hospitalized patients IL-6 IL-6R Inflammation interleukin interleukin 6 Intubated laboratory parameter Laboratory parameters mechanical ventilation morbidity morbidity and mortality Mortality occurred offer outcomes oxygen Oxygen requirements oxygen saturation oxygen saturations oxygen support pathogenic Patient patients patients with SARS-CoV-2 Placebo placebo-controlled Pneumonia predominant Preliminary data profiles proof Randomized rationale reducing required respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV2 Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus Significant reduction significant reductions single-center study supported T-cell temperature therapy Tocilizumab Treatment vasopressor requirement vasopressor requirements vasopressor support
[DOI] 10.1093/cid/ciaa812 PMC 바로가기 [Article Type] Article

Clinical Profile, Treatment and Predictors during the First COVID-19 Wave: A Population-Based Registry Analysis from Castile and Leon Hospitals

Article

Published on 2020-12-142022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS,

[키워드] Acute kidney injury acute respiratory syndrome addition age AKI Analysis Antibiotics antimalarial antivirals clinical Clinical characteristics Clinical outcome COVID-19 COVID-19 pandemic COVID-19 patient death Evolution Factors First wave Gender hospital hospitalized patient hospitals incidence male mechanical ventilation median Medicine Mortality mortality rate Multiple occurred outcome predictor Probability profile Prognosis registry SARS-CoV-2 Severe acute respiratory syndrome Spain steroid syndrome systemic inflammatory response the disease therapy Tocilizumab Treatment variables Ventilation
[DOI] 10.3390/ijerph17249360 PMC 바로가기 [Article Type] Article

Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania

Observational Study

Published on 2020-12-132022-10-04
Journal: Renal failure [Category] SARS, 임상,

[키워드] Abnormalities Admission analyzed Anemia anticoagulation atherosclerotic Care cause chest X-ray Chronic hemodialysis clinical Clinical characteristics Clinical course Clinical features Comorbidity Coronary heart disease cough COVID-19 Cox regression analysis death Diabetic discharged distress Dyspnea Factor fatigue feature Fever Hemodialysis high mortality rate Hospitalization Hospitalized Hydroxychloroquine increased mortality information Kidney disease Lopinavir–ritonavir lower oxygen saturation median age men Mortality nephropathy outbreak outcome oxygen saturation Patient patients patients died patients hospitalized patients with COVID-19 poor prognosis Prophylactic Real-time PCR Result retrospective Romania serum albumin severity significantly higher single-center study Symptom syndrome systemic glucocorticoids Tocilizumab Treatment Vascular with COVID-19
[DOI] 10.1080/0886022X.2020.1853571 PMC 바로가기 [Article Type] Observational Study

Clinical Characteristics of 47 Death Cases With COVID-19: A Retrospective Study at a Tertiary Center in Lahore

Internal Medicine

Published on 2020-12-122022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory distress addition age alveolar analyzed Antibiotics anticoagulation antimicrobial antiviral therapy approval ARDS assessment Asymptomatic Bilateral biochemical BMI C-reactive protein (CRP calculate center Chest Chronic kidney disease clinical Clinical characteristics Clinical features Cohort Combination Comorbidity conducted Coronavirus disease 2019 cough COVID-19 COVID-19 patient D-dimer death demonstrated diabetes died disease course drugs Efficacy elevated epidemiological evaluated ferritin Fever FIVE Gastrointestinal symptom glucocorticoid Ground-glass opacities had no hypertension IBM involved ischemic heart disease life-threatening lung lung field lung involvement male male-to-female ratio management Mortality Most patient Neutrophil-to-lymphocyte ratio nine outcome pandemic pathology Patient patients percentage plasma poor prognosis positive predict predictors predominant prevalent radiological radiological features Remdesivir reported Result retrospective severe disease Shortness of breath significantly SPSS sputum Symptom Symptoms syndrome Teaching Tertiary the mean the patient Tocilizumab Treatment university was used were given
[DOI] 10.7759/cureus.12039 PMC 바로가기 [Article Type] Internal Medicine

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

코로나19로 입원한 환자에서 토실리주맙의 효능

Randomized Controlled Trial

Published on 2020-12-102022-09-12
Journal: The New England Journal of Medicine [Category] Fulltext, MERS, 임상, 진단,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome analyses assigned baseline benefit blockade body temperature comparison confidence interval coronavirus coronavirus disease death disease double-blind effective Efficacy enrolled Fever greater hazard ratio Hispanic hospitalized patient Hyperinflammatory Infection interleukin-6 receptor intubation Latino maintain mechanical ventilation median age median time men outcome oxygen saturation Patient performed Placebo placebo-controlled trial Primary outcome pulmonary infiltrates Randomized Randomly receive receiving SARS-CoV-2 serious infection single dose standard care supplemental oxygen the patient the placebo group time-to-event analysis Tocilizumab women worsening
[DOI] 10.1056/NEJMoa2028836 PMC 바로가기 [Article Type] Randomized Controlled Trial

Post-transplant patients with COVID-19 associated acute respiratory distress syndrome, a role for Tociluzumab: A case series

Case Report

Published on 2020-12-092022-10-29
Journal: Respiratory Medicine Case Reports [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome, COVID-19 Admission age appear benefit case sery caused characterized Clinical improvement computerized tomography, IL Confirmed COVID-19 infection coronavirus disease of 2019, CT correlated COVID-19 COVID-19 patient Critical care Critically ill cytokine release discharged effective therapy high mortality rate high risk hospital Hypothesis inhibitor intensive care interleukin-6 interleukin, CAR-T cell: chimeric antigen receptor T-cell intubation LIST, ARDS mechanical ventilation moderate Patient patients patients with COVID-19 raising Respiratory failure SARS-CoV-2 supplemental oxygen syndrome the disease Tocilizumab treated
[DOI] 10.1016/j.rmcr.2020.101319 PMC 바로가기 [Article Type] Case Report

Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?

토실리주맙은 명백한 부작용 없이 COVID-19 환자에게 마법 같은 치료 효과가 있습니까?

Comment

Published on 2020-12-082022-09-12
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단,

[키워드] COVID-19 patient therapeutic effect Tocilizumab
[DOI] 10.1073/pnas.2009961117 PMC 바로가기 [Article Type] Comment

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses

Research article

Published on 2020-12-062022-10-05
Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료제,

[키워드] acute phase addition Analysis Anti-inflammatory therapy antiviral drug bioinformatics Blood candidate drug cells Chloroquine Clinical use Controlled clinical trial correlated correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Cytokine release syndrome Cytokine storm decrease drug Effect effective evaluated Gene Expression Gene expression analysis gene signature glucocorticoid high mortality rate Hydroxychloroquine IFN-α IFN-β IFN-γ IL6 immune inhibitor interferons lung tissue Macrophage mechanism network analysis neutrophil novel coronavirus SARS-CoV-2 pathogenic Pneumonia receptor regimen SARS-CoV-2 suggested TNF TNFα Tocilizumab Transcriptome Treatment triggered Vaccine
[DOI] 10.1016/j.csbj.2020.11.056 [Article Type] Research article

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab

Case Report

Published on 2020-12-042022-10-29
Journal: Pediatric Reports [Category] COVID-19,