immune responses – Page 58 – Communicable Diseases Research

Treatment patterns in US patients hospitalized with COVID-19 and pulmonary involvement

COVID-19 및 폐 침범으로 입원한 미국 환자의 치료 패턴

Observational Study

Published on 2021-09-012022-09-11
Journal: Journal of medical virology [Category] SARS, 임상, 치료제,

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

급성 SARS-CoV-2 감염 시 뚜렷한 전신 및 점막 면역 반응

Comparative Study

Published on 2021-09-012022-09-12
Journal: Nature Immunology [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection Adaptive immunity Analysis antibodies Bacteria bacterial communities Bacterial community clinical outcomes clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine Cytokines Defense determine elevated highlight Humoral response immune response immune responses Immunity implicated Infection Inflammation Inflammatory cytokines interferon Local microbial Microbiome mucosal mucosal immune Mucosal immunology mucosal surfaces nasopharyngeal Nasopharyngeal swab nasopharyngeal viral load Neutralizing antibodies Paired analysis Pathogenic microorganisms Pathologies pathology patients with COVID-19 performed plasma sample plasma samples Potential PROTECT Protective respiratory infections respiratory tract response responses SARS-CoV-2 SARS-CoV-2 spike-specific SARS-CoV-2-infected patient SARS-CoV-2-infected patients secondary respiratory infections severe acute respiratory syndrome Coronavirus severe COVID-19 specific antibodies systemic immune response systemic inflammatory tissue viral infection Viral load
[DOI] 10.1038/s41590-021-01028-7 PMC 바로가기 [Article Type] Comparative Study

Persistence assessment of SARS-CoV-2-specific IgG antibody in recovered COVID-19 individuals and its association with clinical symptoms and disease severity: A prospective longitudinal cohort study

회복된 COVID-19 개인에서 SARS-CoV-2-특이적 IgG 항체의 지속성 평가 및 임상 증상 및 질병 중증도와의 연관성: 전향적 종단 코호트 연구

Article

Published on 2021-09-012022-09-11
Journal: International immunopharmacology [Category] MERS, SARS, 바이오마커, 진단,

[키워드] addition antibody antibody persistence Antibody titer association clinical symptom Clinical symptoms correlated COVID-19 COVID-19 infection demonstrated diagnosing diagnostic diagnostic test disease disease severity Evidence examined help helping Host humoral immune response humoral immune responses IgG antibody immune responses individual invading pathogen longitudinal cohort study marker Mild moderate MONITOR Neutralizing no decrease pandemic pathogen Pathogens persistence protective immunity provide PSO raise Re-infection real-time RT-PCR recruited robust SARS-CoV-2 SARS-CoV-2-specific IgG serological test Serological tests serum severity Spread subject Support Symptom symptom onset tested vaccination Vaccine development were measured
[DOI] 10.1016/j.intimp.2021.107893 PMC 바로가기 [Article Type] Article

Resourcing, annotating, and analysing synthetic peptides of SARS-CoV-2 for immunopeptidomics and other immunological studies

면역펩티도믹스 및 기타 면역학적 연구를 위한 SARS-CoV-2 합성 펩티드 자원화, 주석 달기 및 분석

Article

Published on 2021-09-012022-09-11
Journal: Proteomics [Category] SARS, 유전자 메커니즘,

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

SARS-CoV-2에 감염된 인간 폐 상피 세포의 차등 숙주 circRNA 발현 프로필

Article

Published on 2021-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis binding cause cell death Circular circular RNA coronavirus coronavirus disease COVID-19 death down-regulated dysregulated enrichment analysis epithelial epithelial cell epithelial cells expression pattern expression profile function functions Gene Expression Gene ontology genomic highly pathogenic Host host immune responses human lung human lung epithelial cells immune immune responses Immunity implicated in viral indicated infected with SARS-CoV-2 Infection Inflammatory responses involved KEGG Lung epithelial cells miRNAs mRNA stability network analysis Ontology parental Pathogenesis performed Proteins regulate regulated RNA RNA binding protein RNA-Seq RNAs SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly up-regulated viral pathogenesis Virus-host interactions
[DOI] 10.1016/j.meegid.2021.104923 PMC 바로가기 [Article Type] Article

Human CD4 + T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential

치료 가능성이 있는 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질의 우세한 에피토프에 특이적인 인간 CD4 + T 세포

Article

Published on 2021-09-012022-09-11
Journal: Clinical and experimental immunology [Category] SARS, 치료법,

[키워드] adverse effects Antigen cancer patient Cancer patients CD4 Cell therapy cellular clone clones coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine response develop dominant epitope Efficacy effort epitope epitope. Epitopes examined focus haematopoietic stem cell transplantation Human identify immune response immune responses immunocompromised individuals immunodominant epitope immunodominant epitopes immunological protection long-lasting Neutralizing antibodies neutralizing antibody nine nucleocapsid protein Protective Protein SARS-CoV-2 SARS-CoV-2 virus sensitivity sequence sequencing approach short-lived spike Spread stem cell Stem cell transplantation T cell T cell receptor T cell response T cell responses T cells TCR the SARS-CoV-2 virus therapeutic potential therapy These data Treatment Vaccine while
[DOI] 10.1111/cei.13627 PMC 바로가기 [Article Type] Article

Association of Varying Clinical Manifestations and Positive Anti-SARS-CoV-2 IgG Antibodies: A Cross-Sectional Observational Study

다양한 임상 징후와 양성 항-SARS-CoV-2 IgG 항체의 연관성: 횡단면 관찰 연구

Observational Study

Published on 2021-09-012022-09-11
Journal: The journal of allergy and clinical immunology. In [Category] SARS, 임상, 진단, 치료법,

[키워드] (anosmia 95% CI ACHE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Anosmia anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibodies antibody Antibody testing association characteristic characteristic symptom clinical clinical manifestation clinical manifestations complex Contact convalescent coronavirus cough COVID diarrhea dysgeusia female Fever headache highest household identify IgG IgG antibody immune responses individual immune response Infection Latent Logistic lowest manifestation muscle ache nasal swab no symptoms nucleocapsid protein IgG observational study Odds ratio Older age oxygen Oxygen therapy Pain participant phenotype Phenotypes positive Prolonged fever proportion receiving respiratory responses SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections Seroprevalence severe acute respiratory syndrome Coronavirus Sex sick Supplemental oxygen therapy symptom clusters Symptomatology Symptoms was performed was used
[DOI] 10.1016/j.jaip.2021.06.046 PMC 바로가기 [Article Type] Observational Study

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

선천성 면역 반응을 조절하는 SARS-CoV-2 뉴클레오캡시드 단백질의 이중 역할

Article

Published on 2021-09-012022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료법,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent contribute coronavirus COVID-19 Cytokines demonstrated early stage effective strategy global pandemic High-dose IFN-I IFN-I signaling immune response immune responses Immunosuppression Infection Inflammatory cytokines innate immune response innate immune responses Innate immunity IRF3 late stage low-dose mechanism N protein nuclear translocation nucleocapsid overactive Pathogenesis pathogenesis of SARS-CoV-2 Phosphorylation promoted Protein regulated Regulatory respiratory retinoic acid retinoic acid-inducible gene I RIG-I SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-like coronaviruses severe acute respiratory syndrome Coronavirus Signaling Stat1 STAT2 suppress suppressed the SARS-CoV-2 Trigger TRIM25 type I interferon
[DOI] 10.1038/s41392-021-00742-w PMC 바로가기 [Article Type] Article

Cytokine storm in severe COVID-19 pneumonia

심각한 COVID-19 폐렴의 사이토카인 폭풍

Article

Published on 2021-09-012022-09-11
Journal: Journal of medical virology [Category] SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome addition Alanine ALT Anemia anti-cytokine anti-cytokine therapy ARDS aspartate AST clinic Confirmed COVID-19 infection coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 pneumonia criteria Cytokine storm decrease determine develop disease elevated elevated lactate dehydrogenase feature ferritin help hemoglobin hemophagocytic lymphohistiocytosis Hospitalized Hyperferritinemia hyperfibrinogenemia Hyperinflammatory syndrome ICU ICU admission identify immnopathology immune immune responses in some include Inflammation intensive care intensive care unit Laboratory laboratory parameter Laboratory parameters Lactate lactate dehydrogenase LDH leukocyte Liver function Liver function test lymphocyte lymphocytopenia Macrophage macrophage activation syndrome Novel coronavirus occurred parameter parameters Patient patients Planning Platelet Pneumonia predict procalcitonin progression reduced respiratory distress Respiratory distress syndrome retrospective cohort study secondary hemophagocytic lymphohistiocytosis Severe COVID-19 pneumonia Severe patient severe pneumonia sHLH significant changes in significantly significantly increased Symptom syndrome the cytokine storm the patient thrombocytopenia transferred Triglyceride troponin two subgroups virus virus classification with COVID-19 worsened worsening
[DOI] 10.1002/jmv.27068 PMC 바로가기 [Article Type] Article

Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection

Multiomics: SARS-CoV-2 감염의 파노라마 전경

Review

Published on 2021-09-012022-09-11
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused cellular cohorts contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical diagnostics Diseases drugs Emerging infectious diseases ENhance Genomics host immune responses identify immune response immune responses immunology Infectious diseases Mechanisms of disease metabolomics molecular Multi-omics pandemic pathogen Pathogenesis pathogenic mechanism pathogenic mechanisms Pathogens proteomics respiratory responsible Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus single-cell Single-cell transcriptomics the disease transcriptomics Vaccine viral infection Virology
[DOI] 10.1038/s41423-021-00754-0 PMC 바로가기 [Article Type] Review