Lipid lowering efficacy and safety of Ezetimibe combined with rosuvastatin compared with titrating rosuvastatin monotherapy in HIV-positive patientsHIV 양성 환자에서 로수바스타틴 적정 단독요법과 비교한 에제티미브와 로수바스타틴 병용요법의 지질강하 효능 및 안전성Research Published on 2015-06-192022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] addition AIP ALT Antiretroviral therapy API apoA1 ApoB Apolipoprotein B appear AST baseline characteristics C-reactive protein change Characteristics cholesterol clinical symptom Clinical symptoms clinical trial Combination combination treatment develop dose dyslipidemia dyslipidemias Efficacy Efficacy and safety eligible examined Ezetimibe group groups guideline HDL-C High-density lipoprotein High-density lipoprotein cholesterol High-sensitivity C-reactive protein HIV HIV-infected patient HIV-infected patients hsCRP improvement increase in LDL-C Lipid lipid profile Low-density lipoprotein Low-Density Lipoprotein cholesterol Mild minimum monotherapy myalgias not differ Open-label parameter Patient patients with HIV percentage plasma Primary outcome Randomized Result Rosuvastatin Safe Significant statin targets therapy Total cholesterol Transport treatment groups Trial Triglyceride two patients [DOI] 10.1186/s12944-015-0054-x PMC 바로가기 [Article Type] Research
Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause RegionsHIV-1 및 프로모터-근위 일시 중지 영역에서 NELF-E RNA 결합 정의Research Article Published on 2014-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition analyzed association Author binding binding activity binding domain Biochemistry cellular claimed compared complex Consensus conserved contribute downstream Drosophila elongation elongation factor eukaryotic facilitate Factor functional Gene Genes Genome high affinity HIV-1 identify in addition to in vitro Interaction modulate molecular negative nuclear nucleotide nucleotides observé pause POLL promoter Protein protein coding gene protein coding genes Protein subunit Quantitative Recognition Region regulate regulated Regulatory required responsible RNA RNA Polymerase II RNA sequence RNA sequences sequence significant increase subunit Support targets thought transcribed Transcription transcription factor transcription factors transcription start site widespread [DOI] 10.1371/journal.pgen.1004090 PMC 바로가기 [Article Type] Research Article
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성Research Article Published on 2012-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation [DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus InhibitorsResearch Article Published on 2011-10-272022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation acute respiratory syndrome anti-infective drug Antiviral antiviral target approach Author automated Bacteria binding blocked common cold viruses CoV CoV-229E CoVs cyclophilin cyclosporin A Cytokine dysregulation demonstrated derivative different drug element Epidemics Factor FKBP1A FKBP1B fungi Host host cell host protein Human identification identify Immune cell include induce Infection Infectious Bronchitis Virus inhibited inhibitor Interaction interaction partner interleukin 2 involved led to maintain metabolism modulate Neurological disease non-structural protein nsp1 organism outbreak overlap parasites pathogen Pathogenesis pathway PPIA PPIB PPIG PPIH Protein Replication SARS-CoV severe SARS suggested Systems biology target targets tested Vaccine Viral protein virus virus virus replication Virus-host interaction viruses [DOI] 10.1371/journal.ppat.1002331 PMC 바로가기 [Article Type] Research Article
Broadly targeted multiprobe QPCR for detection of coronaviruses: Coronavirus is common among mallard ducks ( Anas platyrhynchos )Article Published on 2009-05-042022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] Ct, threshold cycle amplified Ana avian coronavirus competing conserved Coronaviruses CoV CoVs decrease detect detection duck fatal disease fecal samples found Frame FRET, fluorescence resonance energy transfer groups host range Human LNA, locked nucleic acid NQPCR, nuclease-based real-time reverse transcription PCR Nuclease-based probes ORF, open reading frame PCR, polymerase chain reaction Primers probe probes provide QPCR, quantitative real-time reverse transcription PCR Real-time PCR reduced reservoirs respiratory sample reverse transcription PCR RNA, Ribonucleic acid RT-PCR, reverse transcriptase polymerase chain reaction sensitivity sequence Split probe strategy Spread Strains TaqMan targets TD, touch down temperature protocol TET, tetrachloro-6-carboxyfluorescein Transmission variant viral evolution viral nucleic acid [DOI] 10.1016/j.jviromet.2009.04.022 PMC 바로가기 [Article Type] Article