SWIFT: Prospective 48-Week Study to Evaluate Efficacy and Safety of Switching to Emtricitabine/Tenofovir From Lamivudine/Abacavir in Virologically Suppressed HIV-1 Infected Patients on a Boosted Protease Inhibitor Containing Antiretroviral RegimenSWIFT: 항레트로바이러스 요법을 포함하는 강화된 프로테아제 억제제를 사용하는 바이러스학적으로 억제된 HIV-1 감염 환자에서 라미부딘/아바카비르에서 엠트리시타빈/테노포비어로 전환하는 것의 효능 및 안전성을 평가하기 위한 전향적 48주 연구HIV/AIDS Published on 2013-06-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 3TC/ABC 95% confidence interval abacavir addition Arm ARMS backbone baseline characteristics calculated CD4 Characteristics cholesterol compared Containing Decline decrease Decreased defined Efficacy and safety EGFR emtricitabine emtricitabine/tenofovir epidermal epidermal growth factor evaluate FTC/TDF fumarate GFR greater growth factor HIV patient HIV patients HIV-1 Human immunodeficiency virus immunodeficiency virus improvement Improvements Infected inhibitor lamivudine LDL Lipid lipids Lipoproteins Low-density lipoprotein low-density lipoproteins male median median age nucleoside Open-label parameter Patient PI primary endpoint Prospective Protease inhibitor Randomized rebound receiving receptor regimen reverse transcriptase risk score Ritonavir RNA RTV Safety study drug subject suppressed switch switching tenofovir disoproxil fumarate TG The United States threshold Total cholesterol transcriptase treated treatment difference Triglyceride triglycerides United States virologic failure Virologic suppression [DOI] 10.1093/cid/cis1203 PMC 바로가기 [Article Type] HIV/AIDS
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitisResearch Published on 2012-12-142022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] absence accelerate Activation Affect Analysis Anti-viral anti-viral activity Axonal damage bystander CD4 CD4 T cell CD4 T-cell CD4+ and CD8+ T cells CD8 CD8 T cell CD8 T-cell Central nervous system clinical disease CNS compared contribute coronavirus Cytometry decrease Encephalomyelitis ENhance enhanced evaluated Ex vivo expression Flow Gene expression analysis Gliatropic coronavirus help histocompatibility complex IFN-γ IL-21 impede increase Increased Infected Inflammation inhibitory inhibitory signal interactions interferon less Local Lymph node macrophages mice microglia MONITOR morbidity mRNA nitric oxide overcome pathology Population purified reduced regulated Result T helper T-cell T-cell Response target cells upregulation viral control was used were infected [DOI] 10.1186/1742-2094-9-269 PMC 바로가기 [Article Type] Research
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research
Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?Review Published on 2012-05-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive Against antigenic arterivirus, porcine reproductive and respiratory syndrome virus CD25 CD28 CD4 CD8 Cell cells chronic inflammation Coronaviral coronavirus cytokine described develop disease Express expression form hallmark homeostasis host response IL-10 Immune homeostasis immune response immune tolerance induction Infection interleukin 2 lactate dehydrogenase lactate dehydrogenase-elevating virus maintain mean mouse hepatitis virus natural Other Pathogenesis PROTECT receptor Regulatory Regulatory T cell reproductive responsible subset syndrome T cell T cell subset T helper TGF-β the disease transcription factor Type viral persistence virus [DOI] 10.3390/v4050833 PMC 바로가기 [Article Type] Review
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) InfectionResearch Article Published on 2011-07-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type [DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article
Prolonged depletion of circulating CD4 + T lymphocytes and acute monocytosis after pantropic canine coronavirus infection in dogsArticle Published on 2010-06-152022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Alter B cell B cells B lymphocyte baseline level canine Canine coronavirus CD14 CD21 CD4 CD4+ T cell depletion CD8 CD8+ T cells circulating coronavirus Coronavirus infection days post-infection flow cytometry IgM immune infect Infected Infection lymphopenia monocytosis Peripheral blood monocyte Prolonged recovered completely remained returned serum IgG significantly T cell T lymphocyte [DOI] 10.1016/j.virusres.2010.06.006 PMC 바로가기 [Article Type] Article
Hepatitis B and long-term HIV outcomes in co-infected HAART recipientsArticle Published on 2010-04-122023-06-03 Journal: AIDS (London, England) [Category] B형 간염, [키워드] CD4 HAART hepatitis B HIV isolated core hepatitis B Mortality [DOI] 10.1097/QAD.0b013e32832e463a PMC 바로가기 [Article Type] Article
Strain-Dependent Migration of CD4 and CD8 Lymphocyte Subsets to Lymph Nodes in NOD (Nonobese Diabetic) and Control MiceResearch Article Published on 1994-01-012023-08-30 Journal: Developmental Immunology [Category] E형 간염, [키워드] CD4 CD8 homing lymph nodes NOD Strain-dependency [DOI] 10.1155/1994/32820 PMC 바로가기 [Article Type] Research Article