Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article
Genetic drift of human coronavirus OC43 spike gene during adaptive evolutionArticle Published on 2015-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] adaptive Analysis binding binding domain characterized coronavirus CoV CoVs Critical dN/dS dominant Epidemic Evolution FIVE Genetic genetic drift Genotype HCoV-OC43 Health human coronavirus OC43 human population human populations majority mechanism N-terminal domain NTD OC43 persistence phylodynamic Phylogenetic Positive selection prevalent S gene S protein Seven spike gene Substitution sugar the S1 subunit [DOI] 10.1038/srep11451 PMC 바로가기 [Article Type] Article
Genomic Analysis and Surveillance of the Coronavirus Dominant in Ducks in ChinaResearch Article Published on 2015-06-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] cellular China circulating conserved coronavirus deletions demonstrated distribution dominant duck ecological niches Evolution frameshift genetic diversity Genome homologous insertions Lineage occurred Organisms performed prevalent Protein recombination event Region RNA viruses RT-PCR assay sequenced substitutions Surveillance viral genome [DOI] 10.1371/journal.pone.0129256 PMC 바로가기 [Article Type] Research Article
The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다Research Article Published on 2014-10-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation Agrobacterium allele Amino acid Analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type [DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article
An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infectionsResearch Article Published on 2014-08-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] antibody baculovirus both viruses carried caused Cell clinically coronavirus Coronavirus infection domain dominant eight Evolution fatal disease Feline coronavirus Feline infectious peritonitis genotypic genotyping healthy hospital immunofluorescence assay Infection infection rate infections Population predominant Prevalence Recombinant protein Result seropositive Seroprevalence serotype Spike protein Support Taiwan the spike protein Transmission Type type I viral infection virus was used were infected [DOI] 10.1186/s12917-014-0186-7 PMC 바로가기 [Article Type] Research Article
The [ PSI + ] Prion Exists as a Dynamic Cloud of Variants[ PSI + ] Prion은 다양한 변종 클라우드로 존재합니다.Research Article Published on 2013-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles amyloid appear array Author Cell clones cloud conditions conformation different dominant dynamic effective Efficiency Evidence explain expressing growth infectious isolate mitotic growth MOST passage Phenotypes Polymer polymorph prion progeny Protein protein sequence PSI related Saccharomyces cerevisiae segregation sequence Spectrum Spread strain Structure structures subunit Sup35p Support three group three groups translation Transmissibility Transmission transmission efficiency transmission pattern variant variants yeast [DOI] 10.1371/journal.pgen.1003257 PMC 바로가기 [Article Type] Research Article
Identification of Orch3 , a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C자가면역 고환염에 대한 지배적인 내성을 제어하는 유전자좌인 Orch3의 확인, 키네신 계열 구성원 1CResearch Article Published on 2012-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major adjuvants allele alleles animal model Antigen antigen presenting cell antigen presenting cells approach Author Autoimmune Autoimmune disease autoimmune disease susceptibility Autoimmune diseases Autoimmunity autologous characterization chromosome chromosome 11 controlling demonstrated disease disease susceptibility dominant encodes gene etiology exhibiting expression family family member Gene Genetic genetic determinant Genetic predisposition Genome histocompatibility complex identification immunization individual gene individual genes inflammatory disease Kif1c KIF21B KIF5A Kinesin leads loci locus major histocompatibility complex mapped member MHC MHC class MHC class II mice non-infectious orchitis over-expression polymorphism Polymorphisms proliferative Quantitative quantitative trait locus reduced required resistance resistant allele strain susceptibility susceptible T cell T cell responses transcriptional regulation transgenic variety [DOI] 10.1371/journal.pgen.1003140 PMC 바로가기 [Article Type] Research Article
Etiology and Clinical Characterization of Respiratory Virus Infections in Adult Patients Attending an Emergency Department in BeijingResearch Article Published on 2012-02-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addressed Adult assay Attending Beijing characterization checked China clinical clinical symptom conducted Department detected determine different dominant effective Emergency epidemiological finding HCoV-229E Health highlight human coronavirus Influenza virus métapneumovirus nose parainfluenza pathogen Patient picornavirus polymerase chain positive Prevalence profile real-time RT-PCR reported respiratory respiratory syncytial virus respiratory tract infection respiratory virus Respiratory virus infection respiratory viruses reverse transcription RSV Safe significantly tested Therapeutic approach throat swab virus virus infection viruses [DOI] 10.1371/journal.pone.0032174 PMC 바로가기 [Article Type] Research Article
Respiratory viruses involved in influenza‐like illness in a Greek pediatric population during the winter period of the years 2005–2008 † , ‡Research Article Published on 2011-08-112022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] assay children clinician clinics Co‐infection collected Coronaviruses determine diagnosed distribution dominant Epidemiology Greece Inc included Influenza Influenza virus influenza viruses involved majority occurred Older parainfluenza PCR pediatric polymerase chain reaction positive protocols real time respiratory respiratory specimens respiratory syncytial virus respiratory tract infection respiratory virus respiratory viruses rhinovirus rhinoviruses Simultaneous specimen subtype tested to screen virus viruses [DOI] 10.1002/jmv.22173 PMC 바로가기 [Article Type] Research Article
The Replicase Gene of Avian Coronavirus Infectious Bronchitis Virus Is a Determinant of PathogenicityResearch Article Published on 2009-10-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accessory gene avirulent cell tropism Complete demonstrated determinant dominant Genome IBV in vitro Infectious Bronchitis Virus M41 pathogenicity replaced replicase S gene virulence virulent virus [DOI] 10.1371/journal.pone.0007384 PMC 바로가기 [Article Type] Research Article