Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes (VIVALDI): an observational studyObservational Study Published on 2021-09-012022-10-05 Journal: The Lancet. Healthy longevity [Category] SARS, 임상, [키워드] ACE2 binding Adaptive immune response age All participant antibody Antibody Response Antibody titre antibody titres B.1.1.7 B.1.351 B.1.351 variant blood sample BNT162b2 Care Cellular immune response cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine Cohort collected correlated correlation country Coverage COVID-19 COVID-19 mortality COVID-19 vaccination COVID-19 vaccine defined Department Evidence extended interval first dose history humoral IgG antibody immune responses immunoassay Impact independent Infection infection with SARS-CoV-2 Interaction IQR kinetic magnitude median median age of BNT162b2 Older P.1 variant P.1 variants participant Participants peptide positive pre-vaccination profile resident response SARS-COV-2 infection SARS-CoV-2 strain second dose serological evidence significantly lower single dose Spike protein spike-specific IgG T-cell Response tested titre vaccination Vaccine vaccine dose variant variants of SARS-CoV-2 were assessed were excluded [DOI] 10.1016/S2666-7568(21)00168-9 PMC 바로가기 [Article Type] Observational Study
Sensitive detection of anti-spike antibodies enables improved understanding of SARS-CoV-2 pathogenesis스파이크 방지 항체의 민감한 검출을 통해 SARS-CoV-2 병인에 대한 이해 향상Editorial Published on 2021-09-012022-09-11 Journal: Immunology [Category] SARS, 진단, 치료기술, [키워드] active infections anti-spike antibody Anti-viral immune response anti-viral immune responses antibody complement detect ELISA help immune response immune responses immunological protection Infection infections isotype likelihood mass mass vaccination natural infection pandemic positive result predict provide re-infected Saliva SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitive serum specific antibodies spike glycoprotein Test tide turn vaccination Vaccinations Viral viral infection viral infections Viral RNA virus [DOI] 10.1111/imm.13399 PMC 바로가기 [Article Type] Editorial
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approachCOVID-19 발병 기전에서 예측된 SARS-CoV-2 miRNA의 역할 해독: 생물정보학 접근Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Apoptosis apoptotic pathway apoptotic pathways approach bioinformatics computational tool computational tools Coronavirus-2 COVID-19 COVID-19 pathogenesis dataset deregulated down-regulated down-regulated gene e genes enriched pathways function functional enrichment Genes global pandemic Host immune immune responses immune system infected cells infections influence immune responses involved KEGG pathway analysis microRNA miRNA miRNAs modulating molecular mechanism p53 Pathogenesis pathogenicity pathway predicted progression provide regulated Repository SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 miRNA SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling significantly survival target the SARS-CoV-2 transcriptomic profile up-regulated viral miRNA viral miRNAs viral pathogenesis virus [DOI] 10.1016/j.compbiomed.2021.104669 PMC 바로가기 [Article Type] Article
Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome다기관 염증 증후군이 있는 성인 환자의 숙주 유전학 및 항바이러스 면역 반응Immunology Published on 2021-08-312022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] affected affecting analyzed antibody autoantibody autophagy characteristic children classical contributing to Coronavirus disease 2019 Course COVID-19 CXCL10 cytokine Cytokines description disease disease-causing DNA ELISA Exome expression Features FIVE Genetic hallmark hallmarks healthy controls IFNα IL-1β IL-6 immune responses immunological in vitro In vitro infection Inflammatory interferon interferon response interferons Kawasaki disease less MIS mononuclear cell mononuclear cells Multiorgan dysfunction Multisystem inflammatory syndrome organ Pathogenesis Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells Presence Proinflammatory cytokine proinflammatory cytokines reduced response restriction factor SARS-CoV-2 SARS-COV-2 infection Sequencing Sequencing analysis syndrome systemic inflammation TNFα type I type I and III interferons variant WES whole exome sequencing [DOI] 10.3389/fimmu.2021.718744 PMC 바로가기 [Article Type] Immunology
Asymptomatic COVID-19 Individuals Tend to Establish Relatively Balanced Innate and Adaptive Immune ResponsesArticle Published on 2021-08-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute phase age Asymptomatic Asymptomatic case asymptomatic individual Asymptomatic individuals asymptomatic infection avoidance Balanced Clinical characteristics Clinical data Clinical outcome Coagulation comprehensive analysis COVID-19 COVID-19 pandemic CRP decrease demographic characteristics effective feature fibrinogen immune Immune cell Immune phenotype immune response immune responses immunological characteristics increase in individual individual immune response Inflammatory responses Innate Laboratory Lymphocyte count marker MLR MNKR Monocytes NK cells NLR pathogenesis of COVID-19 pathogenic mechanism patients with SARS-CoV-2 performed Perspective potential risk predict proportion Protective Protein response Sample size sample sizes SARS-CoV-2 significantly higher symptomatic individual symptomatic individuals Th17 the disease Treg virus transmission [DOI] 10.3390/pathogens10091105 PMC 바로가기 [Article Type] Article
CytokineLink: A Cytokine Communication Map to Analyse Immune Responses—Case Studies in Inflammatory Bowel Disease and COVID-19CytokineLink: 면역 반응 분석을 위한 사이토카인 커뮤니케이션 맵 - 염증성 장 질환 및 COVID-19 사례 연구Article Published on 2021-08-292022-09-12 Journal: Cells [Category] MERS, 진단, [키워드] Affect applied assigned Atla Blood blood cell Cell cell type communication Consensus contribute COVID-19 Critical cytokine Cytoscape database defined demonstrated disease downstream effort expression data highlighting homeostatic conditions Human identify immune responses immunology Infectious disease inflamed colonic tissues Inflammatory Inflammatory bowel disease Inflammatory diseases information Interaction interactions intercellular Intercellular communication Map molecular weight NDEx network peptides Perturbation platform prevalent Protein receptor Repository resource reveal SARS-COV-2 infection Scientific community secretion subgroup of patients target cells Therapeutic strategies tissue ulcerative colitis [DOI] 10.3390/cells10092242 PMC 바로가기 [Article Type] Article
Recombinant Mycobacterium paragordonae Expressing SARS-CoV-2 Receptor-Binding Domain as a Vaccine Candidate Against SARS-CoV-2 InfectionsSARS-CoV-2 감염에 대한 백신 후보로서 SARS-CoV-2 수용체 결합 도메인을 발현하는 재조합 Mycobacterium paragordonaeImmunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, [키워드] Mycobacterium paragordonae ACE2 Against B cell best candidate cell-mediated immune Cell-mediated immune responses CMI COVID-19 domain evaluated expressing feasibility highlighting humoral immune response humoral immune responses immune response immune responses immunization in vivo Infection Interaction knowledge lead Live virus mice mouse model Mouse models mycobacteria Mycobacterium neutralize Neutralizing neutralizing antibody present raised RBD RBD protein Receptor-binding domain (RBD) recombinant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants single dose the RBD the SARS-CoV-2 vaccination Vaccine vaccine candidate virus infection [DOI] 10.3389/fimmu.2021.712274 PMC 바로가기 [Article Type] Immunology
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-CoronavirusesSARS-CoV-2 및 Pan β-Coronavirus에 대한 향신료의 생물학적 활성 성분의 잠재적 면역 조절 특성Cellular and Infection Microbiology Published on 2021-08-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alleviate Anti-inflammatory antioxidant antioxidants Antiviral antiviral properties bioactive components CCL2 cellular pathway cellular pathways chemokine Clinical outcome component contributing to coronavirus COVID-19 COVID-19 severity diet Effect elevated erythroid Health Health crisis Health Organization highlight HMOX1 homeostasis host cell host cell factor Host immune response host immune responses hypercytokinemia hyperinflammation IL6 IL8 immune responses Immunity inhibiting Interleukins lethality mediators modulate Multiorgan dysfunction Nrf2 nuclear oxidative oxidative stress Pan pathway Pneumonia Potential Prevent pro-inflammatory pro-inflammatory mediator pro-inflammatory mediators promise property PROTECT protective immunity respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus spice spices sustained systemic inflammation tissue damage TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variation World Health Organization β-Coronaviruses [DOI] 10.3389/fcimb.2021.729622 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective ImmunityArticle Published on 2021-08-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome adjuvant adjuvants agonist angiotensin-converting enzyme 2 antibody Cell Cell-mediated immunity Cellular immune response cellular immune responses Combination coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine Critical Diseases domain effective Efficacy elicited ELISA assays ENhance ferret model Health humoral IFN-γ-producing T cell IFN-γ immune responses magnitude mucosal immunity NAb nasal neutralizing antibody producing promote protective immunity RBD resulting robust SARS-CoV-2 SARS-CoV-2 antigen stimulated subunit Subunit vaccine TLR agonist TLR agonists TLR3 Toll-like receptor Vaccine vaccine platform Viral load [DOI] 10.3390/vaccines9090957 PMC 바로가기 [Article Type] Article