Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다Original Article Published on 2020-11-032022-09-12 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, [키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3 [DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article
Is Quarantine for COVID-19 Pandemic Associated with Psychological Burden in Primary Ciliary Dyskinesia?Article Published on 2020-11-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Administered burden Care Chest Chronic disorder ciliary dyskinesia Compliance contributed controls COVID-19 COVID-19 pandemic distress emotional Evaluating explained Frequency group healthy controls Italy lockdown mother no significant difference occurred less outbreak parental parental stress participant Patient primary ciliary dyskinesia Psychological Psychological burden psychological Impact Psychological well-being quarantine questionnaire recruited severe acute respiratory syndrome due to coronavirus 2 significantly increased Stress stress level [DOI] 10.3390/ijerph17218099 PMC 바로가기 [Article Type] Article
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbiditiesReview article Published on 2020-11-012022-10-05 Journal: Pharmacology & therapeutics [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE inhibitor ACE2 receptor Angiotensin-converting enzyme application ARBs blocker bradykinin cardiovascular comorbidity cardiovascular disease cardiovascular system Care caused clinical study Comorbidity coronavirus coronavirus disease CoV COVID-19 COVID-19 patient COVID-19 patients CVD Good Health host cells hypertension IMPROVE infect infected with SARS-CoV-2 Inflammation inhibitor inhibitors media morbidity and mortality pandemic Patient patients treated Prognosis RAAS RAAS inhibitors receptor Regulation respiratory SARS-CoV-2 significantly increased virus [DOI] 10.1016/j.pharmthera.2020.107628 [Article Type] Review article
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million peopleSpecial Populations Published on 2020-10-312022-10-31 Journal: Heart (British Cardiac Society) [Category] COVID-19, MERS, SARS, [키워드] 95% CI ACE ACE inhibitor adjusted Admission African angiotensin receptor blocker ARB association black cardiac risk factors and prevention cohort study collected data confounders COVID-19 COVID-19 disease Cox proportional hazard diabetes diagnosed disease drug Effect England enzyme Epidemiology ethnic group finding geographical region group higher risk hypertension ICU ICU care increased risk inhibitor intensive care medication participant Patient primary care Primary outcome prospective cohort study raise receiving receptor reduced risk resulting risk risk of COVID-19 RT-PCR severe COVID-19 disease severity significant interaction significantly significantly increased sociodemographic factors susceptibility variables with COVID-19 [DOI] 10.1136/heartjnl-2020-317393 PMC 바로가기 [Article Type] Special Populations
Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in KoreaResearch Article Published on 2020-10-292022-10-28 Journal: BMC Cancer [Category] COVID-19, MERS, SARS, [키워드] Acute respiratory infection Affect analyzed clinical feature Collateral coronavirus disease COVID-19 COVID-19 pandemic Delay diagnosed Diagnosis diagnostics dropped Effect Effectiveness Epidemic high mortality hospital incidence involved lung cancer measure nosocomial pandemic Patient physically predicted Prevent preventive measure progression proportion remained Responding Result significantly significantly increased supplementary material Symptoms Transmission Treatment [DOI] 10.1186/s12885-020-07544-3 PMC 바로가기 [Article Type] Research Article
Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort studyResearch Published on 2020-10-292022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] administration Admission association AUC benefit blockade Chinese cohort study Concentration conducted confirmed cases coronavirus disease COVID-19 COVID-19 patients Critical cured defined Diagnosis diagnostic disease severity Efficacy elevated Follow-up group Hospital stay IL-6 IL-6 levels IL-6 receptor In-hospital death interleukin-6 IQR median not significantly different outcome Patient patients with SARS-CoV-2 Predictive Preliminary data Registered remained Result retrospective SARS-CoV-2 sensitivity serum Serum IL-6 severity significantly increased specificity survival tested Tocilizumab Treatment [DOI] 10.1186/s12967-020-02571-x PMC 바로가기 [Article Type] Research
Managing patient flows in radiation oncology during the COVID-19 pandemic Reworking existing treatment designs to prevent infections at a German hot spot area University HospitalOriginal Article Published on 2020-10-292022-10-28 Journal: Strahlentherapie Und Onkologie [Category] COVID-19, MERS, SARS, [키워드] Analysis Avoiding benefit Compliance COVID-19 COVID-19 pandemic COVID-19, SARS-COV-2 cross Daily described Disease transmission, infectious downstream Effect evaluate Health healthcare help hotspot hygiene IMPROVE indicated Infection infections Inpatient Intervention maintain management managing nosocomial COVID-19 Nosocomial infection oncologist oncology pandemic Patient patients Prevent Radiation Radiation dose hypofractionation Radiation Oncology reduced reduction regimen Region resources Result resulting SARS-CoV‑2 SARS-CoV‑2 infection significantly significantly increased stereotactic radiosurgery tested Therapies Treatment university university hospital [DOI] 10.1007/s00066-020-01698-6 PMC 바로가기 [Article Type] Original Article
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma PatientsCell and Developmental Biology Published on 2020-10-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] AAK1 ACE2 addition adenocarcinoma anti-inflammatory effect B cell bioinformatic analysis Cancer patients CD4 T cells Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient death differentially expressed gene Effect endocytic explain expression Factor Health immune Immune cell immune infiltration infiltration Inflammation involved landscape lung adenocarcinoma lung adenocarcinoma (LUAD) malignant tumors novel coronavirus disease outbreak Patient positive Potential Prognosis Regulation SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signaling pathways significantly significantly increased susceptibility susceptible the patient TMPRSS2 Treatment [DOI] 10.3389/fcell.2020.577032 PMC 바로가기 [Article Type] Cell and Developmental Biology
Heightened Circulating Interferon-Inducible Chemokines, and Activated Pro-Cytolytic Th1-Cell Phenotype Features Covid-19 Aggravation in the Second Week of IllnessImmunology Published on 2020-10-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activated adaptive aggravation CD4+ chemokine circulating COVID-19 Critical CXCL10 CXCL8 CXCL9 cytokine cytolytic disease disease pathogenesis disease severity enrolled event feature Frequency IFN IL-10 IL-6 illness immune Immunity immunopathology individual Inflammatory responses investigated Mild mild illness monocyte NK cell no difference Non-classical monocytes observation paO2/fiO2 PaO2/FiO2 ratio pathogenic Patient PBMC phenotype plasma Protective reactive oxygen specy response ROS S/M/N protein-reactive T-cells SARS-CoV-2 SARS-CoV-2-specific T-cell response second significantly increased Symptoms T-cells target Th1 Th1 cell therapy trifunctional Vaccine development Week were assessed were measured [DOI] 10.3389/fimmu.2020.580987 PMC 바로가기 [Article Type] Immunology
Characteristics Associated With Out-of-Hospital Cardiac Arrests and Resuscitations During the Novel Coronavirus Disease 2019 Pandemic in New York CityResearch Published on 2020-10-192022-10-30 Journal: JAMA Cardiology [Category] COVID-19, Fulltext, MERS, [키워드] 95% CI age arrest association cardiac Cardiac arrest cardiac arrests Characteristics circulation Comorbidities Comorbidity confounder coronavirus disease COVID-19 COVID-19 pandemic cross-sectional death deaths defined diabete diabetes electrical exposure Factor Fatality rate finding help hypertension identifying Importance incidence Intervention less limitation limitations main analysis measure medical service men New York New York City novel novel coronavirus disease objective Odds ratio Older Older age outcome pandemic participant Patient peaked physical Point presenting receiving reduce reductions in Relevance remained reported Result Resuscitation risk setting significantly increased statistically significant substantial reduction sustained targeted intervention [DOI] 10.1001/jamacardio.2020.2488 PMC 바로가기 [Article Type] Research