PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-SuppressionReview Published on 2021-01-062024-09-02 Journal: Cancers [Category] 대상포진, [키워드] adenosine CD38 microenvironment Multiple myeloma PD-1 PD-L1 [DOI] 10.3390/cancers13020164 PMC 바로가기 [Article Type] Review
Pentoxifylline: A Drug with Antiviral and Anti-Inflammatory Effects to Be Considered in the Treatment of Coronavirus Disease 2019Pentoxifylline: 코로나바이러스 질병 2019의 치료에 고려되는 항바이러스 및 항염 효과가 있는 약물Article Published on 2021-01-012022-09-11 Journal: Medical principles and practice : international jo [Category] SARS, 치료제, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine monophosphate Anti-inflammatory can not caused China Chloroquine coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cyclic adenosine monophosphate Cytokines disease drug Effect Effects Efficacy elevated Favipiravir feasible Immune cell Immunological studies Immunological study immunomodulatory in vitro increase inhibit inhibitor Lopinavir Migration monophosphate Most patients New coronavirus outbreak Patient patients Pentoxifylline Pneumonia pro-inflammatory cytokine pro-inflammatory cytokines Protein protein kinase reduction in Remdesivir respiratory ribavirin Ritonavir SARS-CoV-2 Serum level severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Spread synthesis the disease Toxicity treatment for COVID-19 turn Viral viral infections virus Wuhan [DOI] 10.1159/000512234 PMC 바로가기 [Article Type] Article
Remdesivir: A Closer Look at Its Effect in COVID-19 Pandemic렘데시비르: 코로나19 팬데믹에 미치는 영향 자세히 살펴보기Review Published on 2021-01-012022-09-11 Journal: Pharmacology [Category] 변종, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine affected Antiviral broad spectrum Bronchoalveolar lavage fluid cell cultures clinical evidence Clinical improvement clinical trial conducted coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic death disease Effect etiology infections inhibited life Middle East mortality rate New nucleotide oxygen Patient positive result prodrug pulmonary infiltrate Recovery time reduced Remdesivir respiratory SARS-CoV-2 selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect Spread syndrome variant variants variants of SARS-CoV-2 Viral Viral load viral replication virus was tested [DOI] 10.1159/000518440 PMC 바로가기 [Article Type] Review
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic OpportunitiesPharmacology Published on 2020-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute lung injury ADA adenosine adenosine deaminase adenosine kinase ADK binding caused CD26 coronavirus COVID COVID-19 COVID-19 pathogenesis develop highlight IMPROVE Infection lung epithelia Lung injury novel coronavirus disease opportunity outbreak outcomes platelet activation receptor reduce respiratory role SARS-CoV-2 SARS-COV-2 infection Spread the disease therapeutic use thrombosis virus [DOI] 10.3389/fphar.2020.594487 PMC 바로가기 [Article Type] Pharmacology
Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19COVID-19 치료에서 레닌-안지오텐신 시스템의 면역 조절제 및 조절제로서의 펜톡시필린의 재배치Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, [키워드] activate adenosine adenosine monophosphate alveolar epithelial cells angiotensin Anti-inflammatory approach AT1R balance cells circulation Concentration COVID-19 cyclic adenosine monophosphate Cytokines damage deleterious effect deleterious effects Endothelium epithelial cells Evidence expression helping highlight immune response immune system immunomodulator IMPROVE in vitro increase Inflammatory cytokine Inflammatory cytokines inhibiting inhibitor Microvascular thrombosis monophosphate mRNA offer patients with COVID-19 Pentoxifylline Prevent Proinflammatory cytokine proinflammatory cytokines Protein protein kinase RAS receptor reduce reduction in Renin renin-angiotensin system repositioning safety profile synthesis Therapeutic treatment thrombosis TNF-α Treatment treatment of COVID-19 turn ventilatory parameters Viral viral clearance [DOI] 10.1016/j.mehy.2020.109988 PMC 바로가기 [Article Type] Article
A potential therapeutic combination for treatment of COVID-19: Synergistic effect of DPP4 and RAAS suppressionCOVID-19 치료를 위한 잠재적인 치료 조합: DPP4와 RAAS 억제의 시너지 효과Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] MERS, SARS, 바이오마커, 치료법, [키워드] ACE-2 addition adenosine adenosine deaminase Affect aldosterone angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Brain caused CD26 cell surface receptor cell surface receptors cells combating Combination component coronavirus coronavirus disease Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 patient diabetes dipeptidyl peptidase Dipeptidyl peptidase-4 disease DPP4 Elderly patient elderly patients enzyme global pandemic heart hypertension immune response implicated kidney Lower respiratory tract men Mortality multiple organs Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Protein RAAS receptor Regulation Renin renin-angiotensin-aldosterone system Renin–angiotensin–aldosterone system. respiratory SARS-CoV-2 suppression synergistic effect therapeutic therapeutic strategy Treatment [DOI] 10.1016/j.mehy.2020.110186 PMC 바로가기 [Article Type] Article
Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon OmegaCase Report Published on 2020-10-272022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] adenosine adenosine nucleoside analogue Administered AGP alpha-1 acid glycoprotein analogue coronavirus diagnosed eye drop Feline infectious peritonitis feline interferon omega forest glycoprotein interferon kidney lesion limits low-dose Lymph node male mesenteric lymph node Mutian nucleoside Omega oral peritonitis polymerase chain precipitates prednisolone acetate Rapid reduced reducing Resolution resolved RNA symmetric dimethylarginine Treatment Uveitis weight loss [DOI] 10.3390/v12111216 PMC 바로가기 [Article Type] Case Report
Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia코비드19-폐렴 환자의 고유량 21% 산소 에어로졸에서 아데노신의 치료 효과Research Article Published on 2020-10-082022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 24 hour 24 hours active treatments adenosine agonist Analysis ARDS bronchospasm change clinical trials control group controlled clinical trials death demonstrated Effect enrolled experimental group feature hemodynamic historical control Hospitalized Infection Inflammatory inflammatory lung disease Inhaled interstitial lack lung Lung disease Lung inflammation mice Mitigation moderate outcome oxygen oxygenated PaO Patient patients treated preclinical studies preclinical study radiological receive receiving receptor recorded reported Result SARS-CoV-2 RNA SARS-CoV2 infection severe lung inflammation severity significant increase syndrome the disease therapeutic effect Treatment Trigger Ventilation were recorded [DOI] 10.1371/journal.pone.0239692 PMC 바로가기 [Article Type] Research Article
Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?Review Published on 2020-09-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] accompanied acute lung injury acute respiratory distress acute respiratory syndrome adenosine ARDS Can clinical conditions compassionate use coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient CT-scan Cytokine storms Cytokines storm develop epithelial feature hypotheses hypoxia immune system Inflammatory cytokine storm inflammatory process inhibit interstitial pneumonia negativity obesity Patient patients with comorbidities Protein receptors reduce respiratory Respiratory failure SARS-CoV-2 SARS-CoV2 detection syndrome the cytokine storm therapy treated turn [DOI] 10.3390/jcm9093045 PMC 바로가기 [Article Type] Review
A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19Remdesivir에 대한 검토: COVID-19 치료를 위한 잠재적인 약제Review Published on 2020-08-062022-09-11 Journal: Drug design, development and therapy [Category] 비임상, [키워드] (RdRp 2019-nCoV active form acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine triphosphate agent animal model animal models ATP breath cause caused Characteristics clinical trial clinical trials competing coronavirus COVID-19 demonstrated development disease drug Ebola virus effective effective therapy Efficacy epithelial cells Google Scholar GS-5734 Human in vitro In vitro studies in vitro study information inhibit management MERS MERS coronaviruses Novel coronavirus nucleoside nucleoside triphosphate phosphoramidate prodrug RdRP Remdesivir respiratory respiratory epithelial cell respiratory epithelial cells review RNA RNA polymerase RNA-dependent RNA polymerase SARS and MERS coronaviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus time-consuming treat Treatment treatment of COVID-19 Vaccine Viral viral replication Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.2147/DDDT.S261154 PMC 바로가기 [Article Type] Review