Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones신규 항말라리아 2-아미노프로필아미노퀴놀론에 대한 잠재적 물성 예측의 설계 및 테스트Article Published on 2020-08-242024-08-26 Journal: Journal of Computer-Aided Molecular Design [Category] 말라리아, [키워드] ADME antimalarial dihydroorotate dehydrogenase drug design PBPK QSAR [DOI] 10.1007/s10822-020-00333-x PMC 바로가기 [Article Type] Article
New anti-viral drugs for the treatment of COVID-19 instead of favipiravirResearch Article Published on 2020-08-122023-06-16 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, [키워드] ADME COVID19 Favipiravir MM-PBSA RNA polymerase [DOI] 10.1080/07391102.2020.1806112 PMC 바로가기 [Article Type] Research Article
Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 proteinResearch Article Published on 2020-07-062022-10-31 Journal: Food Frontiers [Category] COVID-19, [키워드] Ipomoea Obscura (L.) ACE2 ACE2 protein ADME Analysis angiotensin converting enzyme Antiviral effect Compound determine evaluate exhibit GC‐MS Genome host cell host cells inhibitor inhibitory activity involved Ipomoea molecular docking Molecular docking study Pro protease Replication Result SARS‐CoV‐2 SARS‐CoV‐2 suggested target protein target proteins viral genome viral replication [DOI] 10.1002/fft2.29 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological ScreeningReview Published on 2020-07-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activity acute respiratory syndrome addition ADME adverse effects Analysis antiviral agent antiviral drug approved approved drug Chemical Chloroquine clinical impact Clinical studies clinical trials compassionate use complications convalescent plasma coronavirus diagnostic distribution drug effective effort genomic group highlighting Hydroxychloroquine Lopinavir/ritonavir management mechanism metabolism novel pandemic Perspective pharmacological public health Remdesivir SARS-CoV-2 SARS-COV-2 infection Screening These data Vaccine viral infection Viral transmission was recorded [DOI] 10.3390/jcm9072084 PMC 바로가기 [Article Type] Review
Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathwayArticle Published on 2019-08-152024-08-28 Journal: Bioorganic & Medicinal Chemistry [Category] 말라리아, [키워드] 4(3H)-quinazolinone ADME Enzyme inhibition assay P. falciparum Phenylalanine Toxicity study.
Advances in nanomedicines for malaria treatmentArticle Published on 2013-12-312024-09-10 Journal: Adv Colloid Interface Sci [Category] 말라리아, [키워드] 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine absorption, distribution, metabolism and excretion Act ADME AFM Ag NPs area under the plasma level-time curve artemisin combination therapy Atomic force microscopy AUC CCRD central composite rotable design CHOL cholestrol Colloidal carriers DBPC dendrimers DEP DHA dibenhenoyl phosphatidylcholine Dielectrophoresis differencial scanning calorimetry dihydroartemisinin dimyristoyl phosphatidylcholine dimyristoyl phosphatidylglycerol dipalmitoyl phosphatidylcholine dipalmitoyl phosphatidylglycerol distearoyl phosphatidylcholine distearoyl phosphatidylglycerol distearoyl phosphoethanolamine DL DLS DMPC DMPG DNDi DOPC DPPC DPPG drug loading Drugs for Negleted Diseases initiate DSC DSPC DSPE DSPG dynamic light scattering EE egg phosphatidylcholine egg phosphatidylglycerol encapsulation efficiency EPC EPG FACS FFF field-flow-fractionation fluorescence activated cell sorting food vacuole membrane Fourier transformed infrared spectroscopy FTIR FVM HCM host red cell membrane HPMC HPβCD hydroxyl propyl methyl cellulose hydroxypropyl-β-cyclodextrin ICT immune chromatographic tests Institute for One World Health IOWH LC lipids liposomes loading capacity malaria MCT Medicine for malaria venture medium chain triglyceride Micro analysis systems Microfluidics mitochondrial membrane MM MMV nanomedicine Nanostructured lipid carriers new permeation pathways NLC NMR NPP nuclear magnetic resonance ODNs oligodeoxynucleotides PACA parasite plasma membrane PC PCQD PCS PE PG Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol photon correlation spectroscopy Plasmodium PLGA poly (d,l-lactide-co-glycolide) polyalkylcyanoacrylates polymers polypropyleneimine polyvinyl pyrrolidon positively charged qdots PPI PPM PVP RBC RBCM red blood cell red blood cell membrane response surface methodology RSM scanning electron microscopy self-micro emulsifying drug delivery systems SEM Silver nanoparticles SLN SMEDDS Solid lipid nanoparticles TEM TNF-α Toxicity transmission electron microscopy tubovesicular membrane tumor necrosis factor-α TVM WBC White blood cell μTAS. PMC 바로가기