Evolution of Diploid Progenitor Lung Cell Applications: From Optimized Biotechnological Substrates to Potential Active Pharmaceutical Ingredients in Respiratory Tract Regenerative MedicineReview Published on 2021-09-242022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] active pharmaceutical ingredient administration Allogeneic API approach Burn Cell cell banking Cell therapy cell type COVID-19 COVID-19 patient diploid diploid progenitor cells effective effort Evolution FIVE function GMP good manufacturing practice homologous inflammatory lung disease ingredient Local lung lung cell lung cells lung tissue management Medicine MRC-5 cells Patient platform Potential produced progenitor progenitor cell recent regenerative regenerative medicine Research respiratory respiratory tract Safe substrate substrates Symptom syndrome therapeutic therapeutic use therapy tract Vaccine vaccine production vaccine substrate [DOI] 10.3390/cells10102526 PMC 바로가기 [Article Type] Review
Age-Adjusted Endothelial Activation and Stress Index for Coronavirus Disease 2019 at Admission Is a Reliable Predictor for 28-Day Mortality in Hospitalized Patients With Coronavirus Disease 2019Medicine Published on 2021-09-082022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 28-day mortality 95% CI age Allogeneic Analysis blood coagulation disorders characteristic clinical prediction rule Coagulopathy Cohort complications confidence interval coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cutoff death develop endothelial Endotheliitis Endothelium Endpoint Factor help hospitalized COVID-19 patients increased risk index log Mortality Negative predictive value Patient patients performed Positive predictive value predict Predictive Probability Retrospective study risk significantly Stem cell transplantation validation cohort [DOI] 10.3389/fmed.2021.736028 PMC 바로가기 [Article Type] Medicine
Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant RecipientsOncology Published on 2021-09-062022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] administration Against Allogeneic allogeneic HSCT Antibody Response Antibody titer autologous autologous HSCT B cell B lymphocyte BNT162b2 CD19 CD19+ CD20 CD56+ Cell control group correlated correlation COVID-19 immunity cyclosporine Cytometry develop Efficacy evaluate Flow glycoprotein healthy subjects HSCT HSCT recipients immune response immunosuppressive Impaired mRNA-based natural killer negatively affected NK cell NK cells Patient performed Peripheral blood Pfizer-BioNTech platform Prospective Study recipient response rituximab SARS-CoV-2 IgG SARS-CoV-2 vaccine SARS-CoV2 second dose Seroconversion serum sample STEM Stem cell transplantation submitted T cells tested the antibody response the Spike Transplant vaccination Vaccine [DOI] 10.3389/fonc.2021.737300 PMC 바로가기 [Article Type] Oncology
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol
Clinical course of severe COVID19 treated with tocilizumab and antivirals post-allogeneic stem cell transplant with extensive chronic GVHD광범위한 만성 GVHD가 있는 동종 줄기 세포 이식 후 토실리주맙 및 항바이러스제로 치료된 중증 COVID19의 임상 경과Case Reports Published on 2021-08-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] SARS, 진단, 치료제, [키워드] allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Antiviral benefit Cell chronic graft-versus-host disease chronic GVHD clinical Combination coronavirus coronavirus disease coronavirus disease (COVID19) Coronavirus disease 2019 Course COVID-19 COVID19 develop discharged disease eyes full recovery Graft-versus-host disease GVHD Hematopoietic stem cell HSCT humanized monoclonal antibody IL6 Immunocompromised interferon knowledge liver Lopinavir Lopinavir/ritonavir lung male Mortality myelofibrosis Patient pulmonary infections recipient recipients respiratory respiratory manifestation respiratory manifestations ribavirin Ritonavir severe complication severe complications severe COVID-19 shown skin STEM stem cell stem cell transplant Stem cell transplantation Tocilizumab treated [DOI] 10.1111/tid.13576 PMC 바로가기 [Article Type] Case Reports
Possible Reactivation of SARS-CoV-2 in a Patient with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: a Case ReportCovid-19 Published on 2021-07-202022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] acute myeloid leukemia Admission allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation AML Asymptomatic bilateral pneumonia Cell Conditioning COVID-19 COVID-19 vaccine Cyclophosphamide discharge Evidence first dose hematopoietic Hospital stay Hospitalized Immunocompromised patients leukemia lymphopenia male myeloid nasopharyngeal PCR swab PCR test positive question raise Reactivation recipient regimen Reinfection remained report risk SARS-CoV-2 SARS-CoV-2 antibody STEM Stem cell transplantation tested the patient total body Transplant undetectable [DOI] 10.1007/s42399-021-01020-0 PMC 바로가기 [Article Type] Covid-19
Anti-SARS-CoV-2 Immune Responses in Patients Receiving an Allogeneic Stem Cell or Organ TransplantCase Report Published on 2021-07-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Allogeneic allogeneic stem cell transplant anti-SARS-CoV-2 Anti-viral immunity Antibody responses antiviral immune response antiviral immunity autologous build Cell COVID-19 COVID-19 vaccination COVID-19 vaccine Critical Donor immune immune response immune system Immunity immunology immunosuppressive Immunotherapy increased risk Intensive kidney lack malignancy morbidity and mortality Patient Prophylactic Prophylaxis Protective protective humoral immunity recipient response risk SARS-CoV-2 solid organ transplants STEM Stem cell transplantation T cell T cells Transplant Vaccine weakened [DOI] 10.3390/vaccines9070737 PMC 바로가기 [Article Type] Case Report
COVID-19 in recipients of allogeneic stem cell transplantation: favorable outcome Correspondence Published on 2021-06-302022-10-05 Journal: Bone marrow transplantation [Category] SARS, 치료제, [키워드] Allogeneic Cell COVID-19 outcome recipient [DOI] 10.1038/s41409-021-01278-x [Article Type] Correspondence
Complicated pulmonary human coronavirus-NL63 infection after a second allogeneic hematopoietic stem cell transplantation for acute B-lymphocytic leukemia A case report4800 Published on 2021-06-252022-10-30 Journal: Medicine [Category] Coronavirus, MERS, [키워드] acute B-lymphocytic leukemia administration allo-HSCT Allogeneic allogeneic HSCT Alter antiviral therapy body temperature Case report Chest CT Clinical treatment complications Computed tomography coronavirus cough cytokine level death diagnosed Diagnosis diagnostic value DNA and RNA early infection early stage effective exhibited ground-glass opacity HCoV-NL63 high-throughput sequencing of infectious pathogen macrogenome Host HSCT Human human coronavirus NL63 Immunocompromised infecting pathogen Infection Inflammatory leukemia metagenomic Mortality Neutrophil-to-lymphocyte ratio Next-generation sequencing NGS NLR oxygen saturation pathogen Patient post-second allogeneic hematopoietic stem cell transplantation pulmonary lobule returned Sequencing serological test Stem cell transplantation suggested the disease the patient therapy Treatment Treatment outcome underlying disease Viral pneumonia virus [DOI] 10.1097/MD.0000000000026446 PMC 바로가기 [Article Type] 4800
EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients입원한 SARS-CoV-2 감염 환자의 결과 예측을 위한 EASIXImmunology Published on 2021-06-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] 95%CI Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission age allocation Allogeneic angiopoietin angiopoietin-2 (Ang-2) Biomarkers caused Cell Cohort Comorbidities Comorbidity Complication coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlated Course COVID-19 COVID19 CXCL8 CXCL9 death disease dysfunction EASIX endothelial endothelial activation and stress index Endothelial cell Endpoint enrolled Gender hazard ratio health-care system help Hospital admission hospitalized patient hospitalized patients independent Intensive interferon-alpha interleukin Interleukin-18 life-threatening mechanical ventilation multivariable analysis Odds ratio outcome pandemic pathophysiology Patient patients treated patients with COVID-19 predict prediction prediction of outcome primary endpoint resources respiratory Result retained SARS-CoV-2 SARS-CoV2 (COVID- 19) Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus soluble thrombomodulin stem cell Stem cell transplantation Stress suppressor of tumorigenicity 2 (ST2) Surveillance survival the disease thrombomodulin were assessed [DOI] 10.3389/fimmu.2021.634416 PMC 바로가기 [Article Type] Immunology