ameliorated

[키워드] 7-point ordinal scale addition Administered ameliorated animal model animal models anti-viral activity anti-viral drug antibody biochemical marker biochemical markers blood cell blood cell counts changes in clinical benefit clinical benefits clinical severity score clinical status clinical trial Combination Computed tomography cornerstone coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 treatment cytokine death dose Efficacy EudraCT Evidence evidence of Hospital stay Identifier IFNβ-1a IFNβ IFNβ-1a implication in vitro include indicated Inflammatory intensive care intensive care unit INTERCOP INTERCOP trial interferon interferon-stimulated genes International international units intervention arms mild-to-moderate disease moderate disease Mortality mRNA expression profile nasopharyngeal swabs Negative conversion Open-label Ordinal Scale organ dysfunction outcome oxygen oxygen- Patient Pneumonia positive swab Potential Primary outcome pulmonary computed tomography pulmonary computed tomography severity score radiological Randomized Randomized controlled trial rationale reduce reduced reduction regimens Safe SARS-CoV-2 SARS-COV-2 infection secondary Secondary outcomes Serious Adverse Events severity Standard of care Study protocol subcutaneously therapeutic therapy transfer Treatment Trial Trial registration Ventilator-free days Viral Viral load worsening
[DOI] 10.1186/s13063-020-04864-4 PMC 바로가기 [Article Type] Study Protocol