Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS CoV-2 main protease (Mpro) and 3C-like protease for COVID-19 treatmentReview article Published on 2022-04-012022-10-05 Journal: Clinical Nutrition Open Science [Category] 변종, 치료법, 치료제, [키워드] 3CL activities Analysis Anti-viral antiviral activity Antiviral effect cause Chloroquine collected Compound convalescent Convalescent plasma therapy coronavirus Covaxin COVID 19 COVID-19 COVID-19 patient CoVs death Direct docking drug ECG EGCG enzyme Epigallocatechin-3-gallate examined Google Scholar green tea HCQ Health Health care system Human Hydroxychloroquine include inhibitor MPro novel objective occur pandemic pathogen positive positive-sense single-stranded RNA protease representing Result SARS CoV-2 Science suggested Treatment Viral diseases virus [DOI] 10.1016/j.nutos.2021.12.004 [Article Type] Review article
The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19지혈 및 심혈관 질환의 조절과 관련된 페놀 화합물의 항산화, 항혈소판 및 항응고 특성 및 COVID-19에 대한 가능한 영향Review Published on 2022-03-262022-09-11 Journal: Nutrients [Category] 치료제, [키워드] affected animals Anticoagulant antioxidant antiviral activities antiviral activity Antiviral effect antiviral effects benefit blood platelet can not cardiovascular cardiovascular disease cause of death changes in coagulation dysfunction Complication Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Curcumin CVD death Effect Efficiency Evidence Hemostasis Human implication in vitro in vivo less modulation myricetin offer oxidative stress patients with COVID-19 Phenolic compounds Platelet positive Prevent property Prophylactic Prophylaxis recommendation reduce resveratrol risk selected suggested Treatment treatment of COVID-19 while with COVID-19 [DOI] 10.3390/nu14071390 PMC 바로가기 [Article Type] Review
Antiviral activity of molnupiravir against COVID-19: a schematic review of evidencesReview Published on 2022-03-102022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] active form animal model animal models antiviral activity Antiviral effect antiviral efficacy antiviral medicine Cell clinical clinical trials conducted country COVID-19 death Efficacy and safety EIDD-1931 EIDD-2801 evaluate Evidence highly pathogenic Hospitalization in vitro in vivo individuals with COVID-19 infected with COVID-19 lab mechanism of action medication moderate molnupiravir multiple coronaviruses outcome pathogen reduced Replication Research responsible risk SARS-CoV-2 Severe case Spread Treatment Viral RNA [DOI] 10.1186/s42269-022-00753-9 PMC 바로가기 [Article Type] Review
In vivo antiviral effect of plant essential oils against avian infectious bronchitis virusResearch Published on 2022-03-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Anti-inflammatory antibody Antibody titer antiviral drug Antiviral effect bronchitis Clinical signs Concentration cytokine cytokine levels dose effective evaluated glycerol GML group groups High dose highest IBV IBV infection IFN-γ IL-4 IL-6 level immune immune function immune response in vivo infection rate Infectious Bronchitis Virus inhibiting inhibition low dose mRNA expression Mutation organ Plant essential oils positive Protective reduced Result significantly significantly higher significantly lower supplementary material Symptom Vaccine viral loads virus virus multiplication [DOI] 10.1186/s12917-022-03183-x PMC 바로가기 [Article Type] Research
Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibitionSARS-CoV-2 억제용 항바이러스제를 탑재한 표적 나노입자 개발Article Published on 2022-03-052022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] ACE2 ACE2 binding site ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug Antiviral effect antiviral therapeutics binding carriers Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 development Effectiveness etiological agent evaluated example exhibited host cells identify in viral infected Vero E6 cells Intervention Ligand ligands mechanism membrane Novel coronavirus pandemic Perspective pharmacological plethora prophylactic treatment pulmonary tract raised RDV receptor Regulatory Remdesivir representing Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Specific specificity Spike protein Targeted drug delivery Targeted nanoparticles. targets tested therapy for COVID-19 translation Vaccines Vero E6 VERO E6 cells viral entry viral particle Viral particles would increase [DOI] 10.1016/j.ejmech.2022.114121 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Combination Therapy in Patients With Coronavirus Disease 2019 and Primary Antibody Deficiency중증 급성 호흡기 증후군 2019년 코로나바이러스 질환 및 1차 항체 결핍 환자에서 코로나바이러스 2 단일클론항체 병용 요법Article Published on 2022-03-022022-09-12 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome added administration Antiviral effect Clinical outcome common variable immunodeficiency conducted coronavirus coronavirus 2 coronavirus disease COVID-19 deficiencies effective Efficacy mAb mAbs monoclonal monoclonal antibodies monoclonal antibody Patient patients treated polymerase chain primary antibody primary antibody deficiencies. Prospective Study qPCR Quantitative respiratory SARS-CoV-2 SARS-CoV-2-infected patient Standard of care therapy Treatment [DOI] 10.1093/infdis/jiab554 PMC 바로가기 [Article Type] Article
Evaluation of virucidal activity of residual quaternary ammonium-treated surfaces on SARS-CoV-2SARS-CoV-2에 대한 잔류 4차 암모늄 처리 표면의 살바이러스 활성 평가Article Published on 2022-03-012022-09-11 Journal: American journal of infection control [Category] SARS, 변종, [키워드] Ammonium Antimicrobials Antiviral effect applied Belgium biosafety level BSL-3 communicability conditions conducted contaminated surfaces COVID-19 COVID-19 pandemic Degradation demonstrated effective evaluated fomites global health HCoV hCoV-19/Australia/VIC01/2020 Health help independent indicate inoculation isolate Laboratory Level methodology performed proliferation qRT-PCR Quantitative reduce reduction reductions Registered residual RNA SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant silane Support supported surfaces sustained Transmission transmission of SARS-CoV-2 treated Viral RNA virion virucidal virulent [DOI] 10.1016/j.ajic.2021.10.021 PMC 바로가기 [Article Type] Article
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Convalescent Plasma for Preventing Critical Illness in COVID-19: a Phase 2 Trial and Immune ProfileCOVID-19의 중병 예방을 위한 회복기 혈장: 2상 시험 및 면역 프로필Clinical Trial Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 28-day mortality 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Admission Alter anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody Antibody Response Antibody titers Antiviral effect antiviral effects baseline caused circulating co-morbidities co-morbidity comparable Confirmed COVID-19 infection Control controls convalescent plasma coronavirus COVID-19 COVID-19 infection COVID-19 pandemic Critical Critical illness Critically ill death demographics Dexamethasone group hazard ratio Hospital admission ICU IgA level illness immune initial Level morbidities non-critically ill patient non-critically ill patients non-ICU pandemic Pandemics participant Patient PCR Phase 2 Planning plasma populations Preventing profile progression provide reduce reduced reduction in Remdesivir respiratory Respiratory disease Respiratory failure respiratory symptom respiratory symptoms respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly increased single-arm specific antibody statistically significant difference suggestion target protein target proteins tested transfer transfused transfusion Treatment Trial with COVID-19 [DOI] 10.1128/spectrum.02560-21 PMC 바로가기 [Article Type] Clinical Trial
New Insights into Potential Beneficial Effects of Bioactive Compounds of Bee Products in Boosting Immunity to Fight COVID-19 Pandemic: Focus on Zinc and PolyphenolsReview Published on 2022-02-232022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral effect approach bee bee products caused chronic disease Complication Compound contribute coronavirus coronavirus disease COVID-19 develop diabetes dysfunction Effect Epidemic evaluate focus hypertension immune immune system Immunity immunomodulatory information insight natural products New polyphenol polyphenols Population Potential Prevent product reduce Research risk SARS-CoV-2 SARS-COV-2 infection serious complication severity of COVID-19 Symptom Symptoms viral infections Zinc [DOI] 10.3390/nu14050942 PMC 바로가기 [Article Type] Review