Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon ResponseCellular and Infection Microbiology Published on 2021-12-072022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antiviral immunity antiviral response association bind caused characterized coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 downstream evade evasion IFN-I IFN-I response increase inhibit interact interferon regulatory factor JAK1 Janus kinase 1 KPNA6 lack mechanism membrane protein molecular mechanism nuclear translocation patients performed respiratory response SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein Signaling signaling pathway spike Spread Stat1 subunit the spike protein therapeutic target Transcription Treatment Type type I interferon Viral protein [DOI] 10.3389/fcimb.2021.766922 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA systemResearch Article Published on 2021-12-032022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] adaptive Antiviral antiviral action Antiviral effect antiviral immunity Cell cell type Immunity In vitro infection increased expression Innate immunity knockout PIWIL2 Protein protein translation provided reduce reductions in RNA RNA fragment SARS-CoV-2 SARS-CoV-2 genome shown stem cell Viral RNA [DOI] 10.26508/lsa.202101240 PMC 바로가기 [Article Type] Research Article
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan전신 자가면역에서 치료적 mTOR 차단: 항바이러스 면역 및 수명 연장에 대한 시사점Review Published on 2021-12-012022-09-11 Journal: Autoimmunity reviews [Category] SARS, 치료제, [키워드] Activation adaptive Adaptive immune response aging Antigen antigen-presenting cell antiviral immunity APC Autoimmunity blockade Cell cell fate characterized clinical Clinical effect clinical trials cognate antigen conserved contraction COVID-19 infection Critical cytokine Cytokines disease Efficacy Engagement ENhance evaluate Evidence expansion extension form Health healthy highlight Immune cell lineage specification in viral Infection Inflammation Influenza Influenza virus innate immune system Lifespan extension Lineage lupus erythematosus Mechanistic target of rapamycin mTOR pathway Plasma cell Plasma cells preliminary evidence pro-inflammatory Protective protective immunity protein complex provide provided Rapamycin receptor reduce regulatory T cells responsiveness shown Sirolimus SLE SLE patient SLE patients subjects systemic systemic lupus erythematosus T cell T cell activation T cell receptor T cells TCR Th17 Treatment Trial vaccination viral infection viral infections [DOI] 10.1016/j.autrev.2021.102984 PMC 바로가기 [Article Type] Review
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axisSARS-CoV-2는 STAT1-IRF1-NLRC5 축을 표적으로 하여 MHC 클래스 I 경로의 유도를 억제합니다Article Published on 2021-11-152022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] Antigen presentation antiviral immunity COVID-19 patient COVID-19 patients Critical epithelial cell epithelial cell line Gene Expression gene expression profile host response immune evasion inhibit inhibited IRF1 mechanism MHC class MHC class I MHC molecule MHC molecules NLRC5 nuclear ORF6 pathway Protein resulting reveal SARS-CoV-2 SARS-COV-2 infection Signaling Stat1 suppressed T cell T cells target the SARS-CoV-2 transcriptional regulators transcriptionally type II interferon upregulation Viral Viral antigen viral antigens viral infection [DOI] 10.1038/s41467-021-26910-8 PMC 바로가기 [Article Type] Article
Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy개선된 항-SARS-CoV-2 효능을 갖는 Fc-조작된 항체 치료제Article Published on 2021-11-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] activating administration anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody therapeutics antiviral immunity clinical benefit clinical benefits Clinical efficacy Complication COVID-19 COVID-19 disease demonstrated Disease model domain dose driving Effect Efficacy Fcγ receptor High dose highlight Hospitalization hospitalized patient hospitalized patients implication Infection Mild-to-moderate monoclonal antibodies monoclonal antibody Mortality Neutralizing activity pathogenic pathway preventing disease receptor receptor engagement reducing required risk SARS-CoV-2 SARS-COV-2 infection selective severe disease significantly Treatment treatment of COVID-19 weight loss with COVID-19 [DOI] 10.1038/s41586-021-04017-w PMC 바로가기 [Article Type] Article
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunityResearch article Published on 2021-10-222022-10-05 Journal: Cell chemical biology [Category] SARS, 치료제, [키워드] ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral immunity biotinylated caused Clinical treatment Compound coronavirus coronavirus disease Coronavirus-2 COVID-19 domain drug Epidemic Human human cell humans identify immune responses Infection inhibit Interaction interactome ITGB1 knowledge labeling lysine MAVS mechanism membrane protein methyltransferase mitochondrial mitochondrial antiviral-signaling protein pathway Protein provide proximal proximity labeling replication of SARS-CoV-2 resource reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SET SETD2 significantly the interferon Treatment TurboID viral infection Viral protein [DOI] 10.1016/j.chembiol.2021.10.008 [Article Type] Research article
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity바이러스 감염에 대한 SARS-CoV-2 변이체 N501Y.V1 및 N501Y.V2 스파이크의 특성화Cellular and Infection Microbiology Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] antiviral immunity B.1.1.7 B.1.351 characterization contribute coronavirus disease Coronavirus disease 2019 COVID-19 D614G demonstrated drug Efficiency endocytosis evade Host Infection Infectivity inhibitor inhibitors Mutation N501Y N501Y.V1 N501Y.V2 pathogen protease Protein pseudotype pseudovirus raised reported S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variants sensitivity South Africa spike Spread stability stomatitis thermal stability United Kingdom variant variants vesicular stomatitis vesicular stomatitis virus virion virus wildtype [DOI] 10.3389/fcimb.2021.720357 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Impaired function and delayed regeneration of dendritic cells in COVID-19코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연Clinical Trial Published on 2021-10-062022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections [DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial
Interplay Between Non-Canonical NF-κB Signaling and Hepatitis B Virus InfectionArticle Published on 2021-09-292023-05-25 Journal: Frontiers in Immunology [Category] B형 간염, 핵심논문, [키워드] antiviral immunity Hepatitis B virus (HBV) NF-κB-inducing kinase (NIK) non-canonical NF-κB signaling p100/p52 (NFKB2) [DOI] 10.3389/fimmu.2021.730684 PMC 바로가기 [Article Type] Article
Medicinal Plants and Zinc: Impact on COVID-19 Pandemic약용 식물과 아연: COVID-19 팬데믹에 미치는 영향Review Published on 2021-09-232022-09-10 Journal: The Scientific World Journal [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Antiviral antiviral activity antiviral immunity caused coronavirus coronavirus disease COVID-19 Critical death deaths distress drugs dry cough effective fatigue Fever focus Google Scholar immune system Immunity Impact in some Infection pandemic plant plants Previous studies previous study reduce Research respiratory respiratory distress Respiratory distress syndrome respiratory infections SARS-CoV-2 SARS-CoV-2 drug severe acute respiratory syndrome Coronavirus severe pneumonia suggested syndrome Therapeutic approach therapeutic approaches Viral viral infection viral infections Zinc zinc supplementation [DOI] 10.1155/2021/9632034 PMC 바로가기 [Article Type] Review