Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trialCOVID-19 및 사이토카인 방출 증후군(COV-AID) 징후가 있는 환자에서 항인터루킨 약물의 효과: 요인, 무작위, 대조 시험Randomized Controlled Trial Published on 2021-12-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 95% CI assessment assigned baseline Belgium Block randomisation blockade C-reactive protein concentration center challenge Clinical improvement Complete Concentration Controlled trial COVID-19 Cytokine release syndrome D-dimer defined diagnosis of COVID-19 discharge drug Effect Efficacy Endpoint EudraCT evaluate Evidence factorial design failure ferritin fraction hazard ratio hospital hospitalised patient hypoxia hypoxic respiratory failure IL-1 IL-6 IL-6 blockade incidence intention-to-treat analysis intention-to-treat population interleukin International intravenously IQR lactate dehydrogenase less lymphopenia male mechanical ventilation median median age median time morbidity and mortality Mortality mortality risk Most patient multicentre Open-label oxygen PaO pathway Patient patients died patients with COVID-19 Primary outcome randomisation randomised Randomly receive Registered Safety safety population SARS-CoV-2 Serious Adverse Event serious infection serum single dose SOFA SOFA score Stratification study groups study outcome supplemental oxygen Symptom syndrome systemic cytokine therapeutic strategy Tocilizumab treatment group Trial were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00377-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Preparedness and Readiness Strategies for Addressing the COVID-19 Pandemic in Fragile and Conflict Settings: Experiences of the Gaza StripPublic Health Published on 2021-11-222022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] addressed Affect blockade combating conflict COVID-19 COVID-19 pandemic Critical Effectiveness environmental deterioration expected experience Fragile settings Gaza Strip global public health health system hospitals hygiene International lack limits pandemic preparedness readiness resource resources respond Strategies Strategy Support [DOI] 10.3389/fpubh.2021.766103 PMC 바로가기 [Article Type] Public Health
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody LeronlimabCCR5 수용체 점유 분석 결과 항-CCR5 항체 레론리맙 치료 후 말초혈액 CCR5+CD4+ T 세포 증가Clinical Trial Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] antibody assays binding blockade Blood cancer progression CCR5 CD4 CD4+ T cell CD4+ T cells Cell circulating comparable Complete correlated Critical Defense Efficacy facilitate flow cytometric flow cytometry HIV Host Human humans immunological Impact in vivo increase in Increased independent Infectious disease lack macaque macaques Occupancy pathophysiological peripheral Peripheral blood plasma plasma concentration Receptor occupancy receptor occupancy (RO) resulting sensitivity statistically significant suppressed T cell therapeutic Treatment viral replication Viremia Weekly with HIV [DOI] 10.3389/fimmu.2021.794638 PMC 바로가기 [Article Type] Clinical Trial
Follow Your Nose: A Key Clue to Understanding and Treating COVID-19당신의 코를 따르십시오: COVID-19를 이해하고 치료하기 위한 핵심 단서Endocrinology Published on 2021-11-182022-09-12 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 진단, [키워드] ACE2 acting activating Activation adverse effect Affect alveolar cell Anosmia anosmia and ageusia Asymptomatic ATP ATP - adenosine triphosphate basolateral compartment benefit biochemical blockade Cell cells complications of COVID-19 control group cough COVID COVID-19 COVID19 patients death determine Dexamethasone Endothelial cell Exocytosis Factor High dose Hypothesis incidence increase Inpatient Long loss of taste low dose dexamethasone lung lysosomal exocytosis mechanism mineralocorticoid receptor Outpatient paracrine parameter Patient patients with moderate PCR-confirmed COVID-19 patients positive result radiological receptor required respiratory responsible SARS-COV-2 infection severe respiratory failure spironolactone and dexamethasone statistically significant stimulate suggested Symptom the SARS-CoV-2 virus treating Treatment understanding vascular permeability were given with COVID-19 [DOI] 10.3389/fendo.2021.747744 PMC 바로가기 [Article Type] Endocrinology
Autophagy: The Potential Link between SARS-CoV-2 and CancerHypothesis Published on 2021-11-162022-10-31 Journal: Cancers [Category] COVID-19, [키워드] autophagic flux autophagy autophagy machinery blockade Cancer cancer development cancer progression Colorectal cancer colorectal neoplasms Complication component consequence Coronavirus disease 2019 COVID-19 COVID-19 infection disease Evidence gastrointestinal neoplasms highlight highlighting Host host cell Immune checkpoint inhibitors Immune escape implication increased risk individual Infection information Interaction malignancies mechanism Metastasis Neoplasms oncogenic oncogenic viruses oncolytic virotherapy persistence Post-acute COVID-19 syndrome Potential prognosis of patient reactive oxygen species Research resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 protein simple survivor Survivors Symptom syndrome tissue Treatment tumor escape viral particle virus [DOI] 10.3390/cancers13225721 PMC 바로가기 [Article Type] Hypothesis
SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin SystemsSARS-CoV-2는 보체 및 키닌 시스템의 활성화를 통해 COVID-19 병리를 악화시킵니다Immunology Published on 2021-11-052022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] activate Activation acute respiratory syndrome best binding blockade bradykinin C1q classical pathway complement complement system contribute COVID-19 Efficiency ELISA ENCODE generate Genome globular head Human plasma include inflammatory pathway Kallikrein Kallikrein-kinin system Kinin kinin-kallikrein system membrane molecular weight multi-organ failure normal human plasma nucleocapsid peptide peptides platform post COVID “long-haulers” Protein receptor Recombinant protein respiratory SARS-CoV-2 Severe acute respiratory syndrome solid phase SPR structural protein structural proteins surface plasmon resonance System the SARS-CoV-2 therapeutic Treatment treatment of COVID-19 Trigger triggers turn Vasoactive Viral viral particle [DOI] 10.3389/fimmu.2021.767347 PMC 바로가기 [Article Type] Immunology
The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized PatientsActivin/FLRG Pathway는 입원 환자의 COVID-19 결과가 좋지 않습니다.Clinical Trial Published on 2021-11-012022-09-10 Journal: Molecular and Cellular Biology [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] activate activin activin A activin B acute respiratory disease acute respiratory disease syndrome all-cause mortality antibody ARDS Associate blockade breath characterized Comorbidities COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokine storm Cytokines decrease demonstrated develop elevated evaluate Evidence examined FLRG FSTL3 Hospital admission hospitalized COVID-19 patients increase in indicate indicated induce inhibitor lung viral load mechanical ventilation NF-κB NF-κB pathway outcome pathology Poor risk SARS-CoV-2 SARS-COV-2 infection Signaling subset syndrome the disease those with comorbidities treating COVID-19 patient Viral Viral load [DOI] 10.1128/MCB.00467-21 PMC 바로가기 [Article Type] Clinical Trial
Multisystem inflammatory syndrome in children with COVID-19COVID-19 소아의 다기관 염증 증후군Review Published on 2021-11-012022-09-12 Journal: The American journal of emergency medicine [Category] MERS, SARS, 진단, [키워드] Admission Affect anticoagulation blockade Care children children with COVID-19 clinician Combination complication of COVID-19 Corticosteroids COVID-19 diagnose Diagnosis disorder Echocardiogram elevated feature Fever gastrointestinal symptoms include increasingly Inflammatory Inflammatory marker initial treatment intensive care interleukin-1 interleukin-6 Intravenous immunoglobulin Laboratory testing management MIS-C morbidity and mortality neurologic organ pediatric Pediatric patient pediatrics point-of-care Shock Symptom syndrome treat with COVID-19 [DOI] 10.1016/j.ajem.2021.05.076 PMC 바로가기 [Article Type] Review
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C가와사키병 및 MIS-C 환자에서 정맥 면역글로불린에 대한 면역 반응Article Published on 2021-10-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 진단, [키워드] Academy activated Activation acute respiratory syndrome Apoptosis blockade caspase cell death cellular children circulation clinical feature coronavirus COVID-19 Cytometry disease Effect examined expressing flow cytometry foundation heart IL-1 IL-1β Inflammatory Innate innate immune system Innate immunity Intravenous immunoglobulin Kawasaki disease leukocyte population mechanism of action MIS-C NADPH oxidase neutrophil Neutrophils Patient Peripheral blood PI3K reduced robust SARS-CoV-2 signaling pathway syndrome therapy Treatment [DOI] 10.1172/JCI147076 PMC 바로가기 [Article Type] Article
Nutritional behaviors of women and men in Poland during confinement related to the SARS-CoV-2 epidemicArticle Published on 2021-10-072022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] alcohol analyzed blockade BMI body weight caused change changes in COVID-19 pandemic Diseases Epidemic Frequency Gender group Health care in both groups increase in less lockdown men men and women parameter Poland product question questionnaire Research Result Risk factors significantly social isolation the SARS-CoV-2 the study group were assessed women [DOI] 10.1038/s41598-021-99561-w PMC 바로가기 [Article Type] Article