Is copper beneficial for COVID-19 patients?Article Published on 2020-05-052023-06-15 Journal: Medical Hypotheses [Category] MERS, SARS, [키워드] Blood cells Contact killing copper coronavirus COVID-19 Cu-deficiency CuONPs Cupric chloride Immunity ROS SARS‐CoV‐2 Th1/Th2 cells viral infection [DOI] 10.1016/j.mehy.2020.109814 PMC 바로가기 [Article Type] Article
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremiaGLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다Research Article Published on 2018-10-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells [DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article
Unbiased classification of mosquito blood cells by single-cell genomics and high-content imagingArticle Published on 2018-08-072024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] Blood cells Entomology Insect immunity malaria single-cell sequencing
Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors여성의 염증성 사이토카인 수치의 유전적 조상과 집단 차이: 진화적 선택과 환경적 요인의 역할Research Article Published on 2018-06-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adaptive African age alcohol allele Analysis ancestry Antigen antigen receptor Blood cells CCL11 CCL2 chemokine chemokines chronic inflammation circulating circulating cytokines cytokine Cytokines Diseases Endemic environmental factor eosinophils European examined explain exposure to Factor Factors finding gene encoding Genetic genetic difference genetic differences Genetic variant Genetic variation Health Human human immunity IFNα2 IL10 IL1RA IL4 immune immune response immune response genes immune system Immunity implicated implication individual Infection Inflammation Inflammatory Inflammatory cytokine innate and adaptive immunity involved Level living environment living environments Local malaria Migration molecular monocyte Monocytes obesity occur Part pathogen Pathogens phenotypic variance plasma Plasma levels populations pro-inflammatory Protein receptor protein red blood cells Regulation role Selection selection pressure signal significant difference significant differences smoking susceptibility systemic level thought variant Variation White blood cells women [DOI] 10.1371/journal.pgen.1007368 PMC 바로가기 [Article Type] Research Article
Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulationMycobacterium leprae 항원 자극 후 유전자 발현의 유전자 제어 해독Research Article Published on 2017-08-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] activated Affect Antigen bacterium binding site Blood cells caused conducted criteria Differential gene expression disease disease control displaying enrichment eQTL Evidence exposure to expression FDR Gene Expression gene expression level Genetic genetic control Genetic variation Genetic variations genomic highlight Host host genetics host response host responses human host human infectious disease immune Immune cell immune cells Infection Infectious disease Interaction involved knowledge leprosy loci mechanism modulate modulation Mycobacterium leprae natural selection nucleotide outlined pathogen Pathogenesis pathogenicity Patient performed Positive selection proportion Quantitative reaction Regulatory reported Seven significantly Single nucleotide polymorphism single nucleotide polymorphisms SNPs Stimulation suggested susceptibility the disease transcript transcription factor transcription factors transcriptional response triggered upregulation variant variants Variation while whole blood cell whole blood cells [DOI] 10.1371/journal.pgen.1006952 PMC 바로가기 [Article Type] Research Article
Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어Research Article Published on 2016-05-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound [DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway리보솜 단백질 돌연변이는 인슐린 경로의 S6 키나제 억제를 통해 자가포식을 유도합니다Research Article Published on 2014-05-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major activated activating Activation affected affecting AKT Anemia antioxidant aplasia autophagy Blood blood cell Blood cells Bone marrow bone marrow failure Catabolism CD34 Cell cellular conserved Critical cytopenia deregulation disease Embryo etiology event example explanation feature Genes growth growth defects Hematopoiesis impair impairment include increase increase in induce inhibit inhibition insulin insulin resistance insulin-signaling pathway involved kinase lead maturation mechanism Mutation observé opens oxygen p53 pathophysiology pathway Pathways Patient patients phenotype Phenotypes Phosphorylation Potential treatment progenitor cell promote provide reactive oxygen species reactive oxygen specy red blood cell red blood cells Red cell red cell aplasia reduce regulated ribosomal protein ribosome ROS RPS19 SDS Shwachman-Diamond syndrome Signaling signaling pathway Treatment triggered Tumor tumor suppressor while zebrafish [DOI] 10.1371/journal.pgen.1004371 PMC 바로가기 [Article Type] Research Article