Blood cells – Page 6 – Communicable Diseases Research

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

Mycobacterium leprae 항원 자극 후 유전자 발현의 유전자 제어 해독

Research Article

Published on 2017-08-092022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated Affect Antigen bacterium binding site Blood cells caused conducted criteria Differential gene expression disease disease control displaying enrichment eQTL Evidence exposure to expression FDR Gene Expression gene expression level Genetic genetic control Genetic variation Genetic variations genomic highlight Host host genetics host response host responses human host human infectious disease immune Immune cell immune cells Infection Infectious disease Interaction involved knowledge leprosy loci mechanism modulate modulation Mycobacterium leprae natural selection nucleotide outlined pathogen Pathogenesis pathogenicity Patient performed Positive selection proportion Quantitative reaction Regulatory reported Seven significantly Single nucleotide polymorphism single nucleotide polymorphisms SNPs Stimulation suggested susceptibility the disease transcript transcription factor transcription factors transcriptional response triggered upregulation variant variants Variation while whole blood cell whole blood cells
[DOI] 10.1371/journal.pgen.1006952 PMC 바로가기 [Article Type] Research Article

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어

Research Article

Published on 2016-05-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound
[DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article

Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

리보솜 단백질 돌연변이는 인슐린 경로의 S6 키나제 억제를 통해 자가포식을 유도합니다

Research Article

Published on 2014-05-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major activated activating Activation affected affecting AKT Anemia antioxidant aplasia autophagy Blood blood cell Blood cells Bone marrow bone marrow failure Catabolism CD34 Cell cellular conserved Critical cytopenia deregulation disease Embryo etiology event example explanation feature Genes growth growth defects Hematopoiesis impair impairment include increase increase in induce inhibit inhibition insulin insulin resistance insulin-signaling pathway involved kinase lead maturation mechanism Mutation observé opens oxygen p53 pathophysiology pathway Pathways Patient patients phenotype Phenotypes Phosphorylation Potential treatment progenitor cell promote provide reactive oxygen species reactive oxygen specy red blood cell red blood cells Red cell red cell aplasia reduce regulated ribosomal protein ribosome ROS RPS19 SDS Shwachman-Diamond syndrome Signaling signaling pathway Treatment triggered Tumor tumor suppressor while zebrafish
[DOI] 10.1371/journal.pgen.1004371 PMC 바로가기 [Article Type] Research Article