Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjectsArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] affected age antiviral drug approved association baseline blood sample BMI calculated collected comparison Concentration COVID-19 COVID-19 patients COVID-19 severity Efficacy enrolled evaluated glomerular filtration rate GS-441524 ICU identify independent predictor Inpatient Inpatients inter-individual Liver function Logistic regression metabolite Multiple linear regression Multiple regression analysis parameter Patient pharmacokinetic plasma Remdesivir renal renal function required Research SARS-CoV-2 SARS-CoV-2 infections Sex Standard-dose statistical subject transaminase treated Treatment Variability variables were assessed were measured were used [DOI] 10.1093/jac/dkac234 PMC 바로가기
Psychiatric treatment conducted via telemedicine versus in-person consultations in mood, anxiety and personality disorders: a protocol for a systematic review and meta-analysisArticle Published on 2022-09-282022-11-16 Journal: BMJ Open [Category] meta-analysis, [키워드] 95% CI adult psychiatry Anxiety APA approval assessment Bia calculate calculated Chi-square CINAHL comparable conducted COVID-19 COVID-19 pandemic cumulative data set development disorders dropout rate Effect Ethics Evidence heterogeneity include information technology Intervention Major mean difference Meta-analysis methodological outcomes participant Patient satisfaction platform Potential Primary outcome PROSPERO protocol Psychiatric Psychiatric disorders psychiatry PsycINFO randomised controlled trial Repository required risk risk of bia secondary outcome sensitivity analysis systematic review Telemedicine test for heterogeneity Treatment Web of Science widespread [DOI] 10.1136/bmjopen-2021-060690 PMC 바로가기
Cross-GWAS coherence test at the gene and pathway levelArticle Published on 2022-09-262022-11-16 Journal: PLoS Computational Biology [Category] 변종, [키워드] 25OHD affecting Algorithm analyses Analysis approach association bone structure calculated Cell Chemokine receptor coefficients concentrations correlated cumulative datapoint detect distribution Effect effect size expression genetic link Genetic variant Genome-wide association study GWAS immune response independent integrin linear combination medication pathway Pathways positive Precision rheumatoid arthritis serum calcium severity of COVID-19 structures traits utility [DOI] 10.1371/journal.pcbi.1010517 PMC 바로가기
Recursive state and parameter estimation of COVID-19 circulating variants dynamicsArticle Published on 2022-09-232022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, [키워드] addition assumed Brazil calculated changes in circulating variant circulating variants Coverage COVID-19 Deceased Efficacy Epidemic evaluate Gamma Google mobility data health system Hospitalized indicated individuals Intervention intrinsic Kalman filter measure mutability Mutation mutations pandemic parameter performed severity Simulation social distancing state the disease the SARS-CoV-2 virus Transmissibility vaccination Vaccine variant were used [DOI] 10.1038/s41598-022-18208-6 PMC 바로가기
Lactate dehydrogenase/albumin ratio as a prognostic factor in severe acute respiratory distress syndrome cases associated with COVID-19Article Published on 2022-09-232022-11-15 Journal: Medicine [Category] 바이오마커, [키워드] acute respiratory distress Admission affected affecting Analysis ARDS AUC Biomarker C-reactive protein calculated can be used caused characteristic Clinical characteristics confidence interval COVID 19 COVID-19 COVID-19 diagnosis determine early stages evaluated Factors FIVE high mortality hospital ICU in-hospital mortality independent independent risk factor intensive care laboratory result lactate dehydrogenase LDH lung damage marker Mortality mortality rate multivariate logistic regression Patient patients hospitalized predict predicted Prognosis prognostic biomarker Prognostic factor regression analysis severe ARDS syndrome Tertiary the patient was performed were recorded with COVID-19 [DOI] 10.1097/MD.0000000000030759 PMC 바로가기
Mortality Risk Among Patients Hospitalized Primarily for COVID-19 During the Omicron and Delta Variant Pandemic Periods – United States, April 2020-June 2022Article Published on 2022-09-162022-11-16 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, [키워드] adjusted age calculated cause CDC Clinical characteristics COVID-19 COVID-19 hospitalization database deaths Delta early treatment Ethnic groups females Health authority hospital hospitalized COVID-19 patient hospitalized patients In-hospital death in-hospital mortality increase indicated lower mortality male medical condition Medical conditions Mortality mortality risk nonpharmaceutical intervention occurred omicron pandemic Patient patients hospitalized Period proportion public health Racial reported risk United States variant variant of SARS-CoV-2 virus [DOI] 10.15585/mmwr.mm7137a4 PMC 바로가기
Tissue-specific pathway activities: A retrospective analysis in COVID-19 patientsArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 receptor activity Affect affected Alter anticoagulation arachidonic acid calculated changed changes in cholesterol Coagulation complement COVID-19 COVID-19 patient COVID-19 patients example expressed highlight Inflammation less linolenic acid lung Map mapped mechanism metabolism molecular multiple tissues non-COVID-19 patient organ other tissue pathway pathway activity Pathways progression Protein proteomics data RAS regulatory pathway reported Retrospective analysis SARS-CoV-2 SARS-COV-2 infection spleen the disease thrombosis Thyroid tissue tissue-specific proteomics data. tissues virus WikiPathways Wilcoxon test [DOI] 10.3389/fimmu.2022.963357 PMC 바로가기
Inflammatory Biomarkers Associated with In-Hospital Mortality in Critical COVID-19 PatientsArticle Published on 2022-09-092022-11-15 Journal: International Journal of Molecular Sciences [Category] 바이오마커, [키워드] Analysis AST calculated Clinical course contribute COVID-19 COVID-19 pandemic creatinine Critical critical COVID-19 patients CRP cut-off demonstrated diagnosed with COVID-19 global healthcare groups healthcare identify IL-6 in-hospital mortality in-hospital mortality rate Inflammation Inflammatory biomarker inflammatory parameter INR Kaplan-Meier survival curve laboratory parameter marker Mortality non-survivor parameter Patient patients performed Predictive prognostic reducing retrospective risk stratification ROC significantly higher statistical analysis statistically significant statistically significant difference survival survivor thresholds urea WBC [DOI] 10.3390/ijms231810423 PMC 바로가기
New Chemicals Suppressing SARS-CoV-2 Replication in Cell CultureArticle Published on 2022-09-052022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] antiviral drug binding calculated candidate Cell Cell culture Chemical Compound coronavirus cytotoxicity database derivatives develop docked docking EC50 value experiment experiments inhibit SARS-CoV-2 inhibitor inhibitors Ligand main protease molecular MPro New protease protein-ligand quantum chemistry. Replication SARS-CoV-2 SARS-CoV-2 replication selected Selection Seven solvent state suppressed Suppressing the SARS-CoV-2 university Vero E6 [DOI] 10.3390/molecules27175732 PMC 바로가기
Increasing COVID-19 vaccination in the United States: projected impact on cases, hospitalizations, and deaths by age and racial groupObservational Study Published on 2022-09-012022-10-04 Journal: Public health [Category] 임상, [키워드] age benefit black calculated Cases avoided CDC center Control COVID-19 COVID-19 case COVID-19 cases COVID-19 illness COVID-19 infection COVID-19 vaccination death Deaths avoided equity groups Hospitalization hospitalizations Hospitalizations avoided identify implication incidence Increasing infected with COVID-19 outcome Population populations prevention Racial reduce regimen the United State The United States Vaccinating vaccination rate Vaccine were used [DOI] 10.1016/j.puhe.2022.06.019 PMC 바로가기 [Article Type] Observational Study