Assessment of Simulated SARS-CoV-2 Infection and Mortality Risk Associated With Radiation Therapy Among Patients in 8 Randomized Clinical Trials8건의 무작위 임상 시험에서 시뮬레이션된 SARS-CoV-2 감염 및 방사선 요법과 관련된 사망 위험 평가Research Published on 2021-03-292022-09-10 Journal: JAMA Network Open [Category] 임상, [키워드] accelerated analyzed approach assessment benefit Breast cancer Cancer Cancer therapy Care Case fatality rate case fatality rates CFR CFRs changes in clinical clinical trial clinical trials COVID-19 COVID-19 pandemic Cox proportional hazard Cox proportional hazards decreased mortality early stage Effectiveness Estimated evaluated expected exposure Factor fast finding flexible fraction fractionation Fractions higher risk hypo Impact Importance Inclusion infection risk IRF IRFs Kaplan-Meier Local measure median moderate Modification Mortality mortality rates objective oncology outcome outcomes overall survival pandemic participant Patient patients Point Precaution Prostate cancer provide Quantitative quantitative framework Radiation radiation therapy randomized clinical trial randomized trial randomized trials receipt receiving rectal rectal cancer reducing regimens Relevance Result risk SARS-CoV-2 SARS-COV-2 infection scenario setting significantly Support survival Treatment treatment arm Trial [DOI] 10.1001/jamanetworkopen.2021.3304 PMC 바로가기 [Article Type] Research
Repurposing approved drugs for cancer therapy암 치료를 위해 승인된 약물의 용도 변경Review Published on 2021-03-252022-08-31 Journal: British medical bulletin [Category] 신약개발, 유전자 메커니즘, [키워드] Abivertinib activities adverse event adverse events alterations anti-inflammatory compounds approved approved drug approved drugs Area Better can be used can not Cancer Cancer therapy chemotherapeutics Chemotherapy chromosome clinical trial clinical trials Covid-19 adjuvant treatments cytokine Cytokine storm Cytokines cytotoxicity diabete diabetes drug drug activity drug combinations drugs ENhance ER stress growth help IFN IL-2 IL-6 indication induce Inflammation inhibitor inhibitors interferon interferons interferons (IFN) interleukin interleukin-2 interleukin-2 (IL-2) interleukin-6 Kinase inhibitor kinase inhibitors knowledge limit literature mechanism metabolism metformin Mutation mutation rate Mutation rates Necrosis Patient proteolysis proteosome inhibitors receptor inhibitors reducing repurposing Side effect Side effects Symptom target gene thalidomide TNF treat Treatment Tumor tumor cell tumor cells tumor necrosis tumor necrosis factor tumor necrosis factor (TNF) tumorigenesis tumors tyrosine tyrosine kinase inhibitor unfolded protein response unfolded protein response (UPR). UPR [DOI] 10.1093/bmb/ldaa045 PMC 바로가기 [Article Type] Review
COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune responseCOVID-19는 암 관리 및 세포 증식, 사멸, 이동 및 면역 반응의 암 관련 조절자를 위한 임상 마커를 사용합니다.Article Published on 2021-03-042022-08-31 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, [키워드] biological processe biological processes Cancer cancer patient Cancer patients Cancer therapy Cell cell proliferation clinical clinical decision clinical marker clinical markers clinical observations COVID-19 death Diagnosis diagnostic Diversity EGF endothelial engage Engagement epidemiological epithelial FGF immune response immune system immune system cells infected with SARS-CoV-2 initiated Intersection management marker mechanism Migration modifications network network analysis observation pathway Pathways predicted Prognosis provide rationale regulator Regulatory Regulatory networks retrieved SARS-CoV-2 smooth muscle Support Symptom TGFβ Treatment Tumor tumor suppressors tumorigenesis understanding VEGF virus was used [DOI] 10.1038/s41598-021-84780-y PMC 바로가기 [Article Type] Article
Not COVID-19, Don’t Overlook Pneumocystis in Patients on Gefitinib!Case Report Published on 2021-02-212022-10-31 Journal: Current Oncology [Category] COVID-19, MERS, [키워드] abnormality Bronchoalveolar lavage cancer patient Cancer therapy Computed tomography Corticosteroids COVID-19 Diagnosis Dyspnea Final gefitinib increased risk inhibitor lung cancer Mortality PCR physician Pneumocystis jirovecii Pneumonia positive risk RT-PCR simple treated tyrosine tyrosine-kinase inhibitor [DOI] 10.3390/curroncol28010094 PMC 바로가기 [Article Type] Case Report
Exploring novel and potent cell penetrating peptides in the proteome of SARS-COV-2 using bioinformatics approachesResearch Article Published on 2021-02-192022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] addition analyses approach binding bioinformatics calculated Cancer therapy Cell cell membrane cells cellular coronaviruses family CPP Efficiency evaluated Features herpes simplex highest HIV-1 homing Host HSV-1 immunodeficiency in silico Infection investigated main role mammalian cells membrane molecular weight motif NLS nuclear penetrate Penetrating penetration peptide physicochemical property predicted Probability proteome proteome of virus residue SARS-CoV-2 sequence submitted Toxicity Vaccine virus [DOI] 10.1371/journal.pone.0247396 PMC 바로가기 [Article Type] Research Article
The tele-transition of toxicity management in routine oncology care during the severe acute respiratory syndrome (SARS-CoV-2) pandemicArticle Published on 2021-02-092022-10-28 Journal: British Journal of Cancer [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis Cancer cancer centre Cancer therapy Care cough effective enrolled feasible Fever Health services initial introduced maintain management offered oncology Other outcome Outpatient pandemic Patient positive positive PCR Registered Result resulting retrospective cohort SARS-CoV-2 Seroconversion Signs and symptoms Symptom Symptoms telehealth the SARS-CoV-2 therapy Toxicity [DOI] 10.1038/s41416-020-01235-3 PMC 바로가기 [Article Type] Article
Time to SARS‐CoV‐2 clearance among patients with cancer and COVID‐19Original Research Published on 2021-02-092022-10-31 Journal: Cancer Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Cancer Cancer center cancer patient Cancer patients Cancer therapy Care CDC CDC criteria center Chemotherapy clearance clinical clinical criteria Cohort Control coronavirus coronavirus disease COVID‐19 COVID‐19 criteria expected extension first positive hospital Infection infection control less median median time nasopharyngeal Patient Patients with cancer polymerase chain positive precautions prevention Result retrospective cohort study RT‐PCR SARS‐CoV‐2 Society Symptoms the median time transcriptase [DOI] 10.1002/cam4.3708 PMC 바로가기 [Article Type] Original Research
Determinants of Health and Physical Activity Levels Among Breast Cancer Survivors During the COVID-19 Pandemic: A Cross-Sectional StudyPhysiology Published on 2021-02-052022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] activity Administered Breast Breast cancer Breast neoplasms Cancer patients Cancer therapy cancer treatment Course COVID-19 COVID-19 pandemic COVID-19-related symptoms cross-sectional decrease determinant Epidemiological study evaluate exhibited Factor had more incidence of COVID-19 Increased Intervention investigated Level objective pandemic pandemic (COVID-19) participant participated physical activity physical activity level physical activity levels Physical inactivity Prevent reported Result returned risk Sedentary behavior sedentary time social distancing Specific survivor Survivors survivorship university [DOI] 10.3389/fphys.2021.624169 PMC 바로가기 [Article Type] Physiology
Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?Thymoquinone: SARS-CoV2에 감염된 암 환자의 타이 브레이커?Review Published on 2021-02-022022-08-31 Journal: Cells [Category] MERS, 신약개발, 치료제, [키워드] adjuvant Anti-inflammatory anti-SARS-CoV-2 Antibiotics anticancer anticancer drugs antioxidant effect antioxidant effects antipyretics Antiviral antiviral therapies Apoptosis Cancer cancer patient Cancer patients Cancer therapy caused Combination Comorbidity Complication complications coronavirus disease COVID-19 COVID-19 complications COVID-19 infection COVID-19 treatments develop drug Effect Effects General population GRP78 healthcare higher risk Hydroxychloroquine Immunocompromised include Infection ingredient initiated malignancy medications Mild symptom mild symptoms multiple-organ Nigella Sativa Nrf2 pandemic pathophysiology Patient symptoms patients Plasma transfusion RAS reported respiratory SARS-CoV-2 serious complication Severe acute respiratory syndrome Supportive treatments Symptom Symptomatic treatment therapy thymoquinone Treatment Vaccine Viral viral infection virus [DOI] 10.3390/cells10020302 PMC 바로가기 [Article Type] Review
COVID-19 in Patients with Hematologic Malignancies: A Single-Center ExperienceConference abstract Published on 2020-11-042022-10-05 Journal: Blood [Category] 유전자 메커니즘, [키워드] Absolute lymphocyte count active cancer acute respiratory syndrome age ALC Allogeneic autologous B-cell lymphoma board Cancer therapy cardiac disease Care Cell center Cohort cohort of patient collected Comorbidities Complication conditions conducted coronavirus cough COVID-19 COVID-19 diagnosis COVID-19 in patient COVID-19 infection database defined demographic characteristics described Diagnosis diagnosis of COVID-19 died download electronic medical records expected experience Fever for inclusion funding health system Hematologic malignancy higher risk HM patient Hospital admission ICU immune dysfunction impacted include Infection Innate intubation Jazz Kiowa laboratory data lymphopenia majority median mortality rate Multiple myeloma Nasopharyngeal swab network Older age outcome pandemic Patient patients patients with HM positive result presenting symptom presenting symptoms Prevalence promote rates of infection real-time RT-PCR required Retrospective study risk factor robust SARS-CoV-2 SCT Seattle severe COVID-19 Shortness of breath shown Smokers social distancing specimen subsequent supportive care symptomatic table therapy treated Treatment Two patient underlying disease with COVID-19 [DOI] 10.1182/blood-2020-140719 [Article Type] Conference abstract