chance – Page 6 – Communicable Diseases Research

De novo and inherited private variants in MAP1B in periventricular nodular heterotopia

심실주위 결절성 이형에서 MAP1B의 드 노보 및 유전된 사적 변이체

Research Article

Published on 2018-05-082022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] abnormality affected allele Analysis arising association Author Brain brain development caused chance Collapsing controls cortical de novo de novo mutation de novo mutations detrimental Diseases disorder driven by ENCODE epilepsy Exome exome sequencing expected explain fetal Genetic genetic risk Genetic variant genetic variants genome-wide significant heterozygous variant identify implicated incomplete penetrance indicate individual initial involved leads list of gene loci loss-of-function malformation MAP1B Migration Mutation Neuron neurons nonsynonymous occur one patient parent parents patients performed predominant Protein responsible sequence sequenced Sequencing the disease the patient transmitted variant variants
[DOI] 10.1371/journal.pgen.1007281 PMC 바로가기 [Article Type] Research Article

Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent

혈통에 의한 신원을 사용하여 지역 Plasmodium falciparum 말라리아 기생충 개체군 간의 연결성 정량화

Research Article

Published on 2017-10-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Accessibility analysis approach approach assessment association Author best biological processe biological processes can not chance classic classical clinics collected data set descent detect disease dispersal Divergence drug resistance Ecology effort eliminating endangered species Epidemiology Evolution Genetic genomic data Genomics genotyped human pathogen IBD identity identity by descent increasingly inheritance knowledge Local malaria malaria parasite malaria parasites measure Molecular epidemiology nucleotide organism Organisms parasite Plasmodium falciparum Population power provide proximal Recombination required robust sampling sequenced significant decrease Single nucleotide polymorphism single nucleotide polymorphisms SNPs spatiotemporal Spread Surveillance Transmission transmission patterns whole genome
[DOI] 10.1371/journal.pgen.1007065 PMC 바로가기 [Article Type] Research Article

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

관련성 전체 스펙트럼에 걸친 일배체형 단계에 대한 일반적인 접근 방식

Research Article

Published on 2014-04-172022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Molecular Networks of Human Muscle Adaptation to Exercise and Age

운동과 나이에 대한 인간 근육 적응의 분자 네트워크

Research Article

Published on 2013-03-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 13q21 1q12 activated all-trans-retinoic acid Activation adaptation age Ageing all-trans-retinoic acid alteration Analysis applicability aryl-hydrocarbon receptor signaling ATRA Author chance chromosomal Cohort cohorts component Compound continuum contributed developmental processe developmental processes Differential analysis displaying DNA topoisomerase down-regulation driven by EET endurance exercise endurance exercise training Epigenetic events exercise exhibited found Gain Gene gene-expression gene-networks gene-set gene-sets generate Genes growth Health care Health care system health care systems Human hypertrophic response hypertrophic responses hypertrophy identify Impact independent individual individuals Ingenuity Pathway Analysis inhibited Interaction IPA lean mass life loci Longevity mimicking molecular molecular network molecular networks mTOR muscle muscle age muscle growth Musculoskeletal network Older overlap pathway phenotype physical activity post-transcriptional processe post-transcriptional processes profile proportion Quality of life Rapamycin reduced referred to regulated related resistance-exercise training RET retinoic acid ribosomal genes rising risk RNA signature RNA signatures rRNAs RXR sarcopenia sarcopenic Serotonin Signaling significantly Society stream subject topoisomerase transcript unique Z-score
[DOI] 10.1371/journal.pgen.1003389 PMC 바로가기 [Article Type] Research Article

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

공통 변이체는 매우 작은 개체를 제외하고 분포 꼬리의 키에 대한 예측된 다유전자 효과를 보여줍니다

Research Article

Published on 2011-12-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major allele Author average calculated chance classic cohorts common common disease common variants complex decrease determine discrepancy distribution Effect effect size Effects effort expectation expected explain explained extreme Factor found fraction Frequency Genetic Genetic variant Genetic variation Height Human genome implication include individual individuals less loci low frequency Odds ratio Odds ratios phenotype Phenotypes population-based cohort Predictive quantitative traits short stature show shown significantly stature tail trait traits variant variants Variation whole-exome sequencing whole-genome
[DOI] 10.1371/journal.pgen.1002439 PMC 바로가기 [Article Type] Research Article