Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative reviewReview Published on 2022-03-302023-06-15 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, [키워드] combination therapy COVID-19 infection Cytokine storm doxycycline Ivermectin SARS-CoV-2 [DOI] 10.1016/j.jiph.2022.03.014 PMC 바로가기 [Article Type] Review
In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolateSARS-CoV-2 Omicron B.1.1.529 분리주에 대한 치료 항체의 시험관 내 평가Article Published on 2022-03-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] analyzed antibodies antibody B.1 B.1.1.529 BavPat1 cilgavimab Clinical efficacy combination therapies combination therapy D614G dose doses Efficacy eight evaluated loss of activity modify monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity omicron Omicron variant reduction reduction in resulting SARS-CoV-2 Sotrovimab spike glycoprotein Spread Substitution the antibody therapeutic therapeutic antibodies Tixagevimab Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41598-022-08559-5 PMC 바로가기 [Article Type] Article
Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients아달리무맙과 인플릭시맙은 SARS-CoV-2 항체 반응을 손상시킨다: 생물학적 치료를 받은 11,422명의 환자를 대상으로 한 치료 약물 모니터링 연구의 결과Article Published on 2022-03-142022-09-11 Journal: Journal of Crohn's & colitis [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] adalimumab anti-TNF antibody reactivity Antibody Response Antibody testing attenuate biologic bowel causal relationship CLARITY combination therapy confounding factors COVID-19 cut-off detectable drug drug level drug levels drugs Immune-mediated inflammatory diseases immunomodulator Immunosuppression Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab influence Laboratory magnitude median median age median time monitoring Necrosis Patient patients PCR testing PCR-confirmed positive Rate reactivity responses Result SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR seroconvert serological serological response seropositive Seropositivity Seroprevalence serum Support therapeutic drug Therapeutic Drug Monitoring treated Treatment treatment groups undetectable vaccination vedolizumab were measured [DOI] 10.1093/ecco-jcc/jjab153 PMC 바로가기 [Article Type] Article
Oral antivirals for the prevention and treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 예방 및 치료를 위한 경구용 항바이러스제Article Published on 2022-03-012022-09-11 Journal: AIDS reviews [Category] SARS, 변종, 치료제, [키워드] advent Antiviral antiviral therapy antivirals benefit classical combination therapies combination therapy complications COVID-19 COVID-19 disease COVID-19 pandemic Disease progression dissemination Each early treatment Emergency use authorization escape mutant Formulation Infection landscape life-threatening Long-ActingAntivirals manifestation medications Medicine molnupiravir monoclonal antibodies monoclonal antibody Mutagenesis Nirmatrelvir offer oral Oral Remdesivir parenteral administration polymerase Prevent Prophylaxis protease protease inhibitors PROTECT provided reduce regulatory agencies regulatory agency Remdesivir required SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease small molecule treat Treatment Vaccine variant viral illnesses waning immunity [DOI] 10.24875/AIDSRev.22000001 PMC 바로가기 [Article Type] Article
COVID-19 acute respiratory distress syndrome: A simulation study of the effects of combination therapy with tocilizumab and siltuximabCOVID-19 급성 호흡곤란 증후군: 토실리주맙과 실툭시맙 병용 요법의 효과에 대한 시뮬레이션 연구Article Published on 2022-03-012022-09-12 Journal: British Journal of Clinical Pharmacology [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS binding binding constant blockade Bronchoalveolar lavage fluid combination therapy complex component Concentration COVID-19 COVID-19 patient develop Effect generate greater IL-6 IL-6 antagonist IL-6 level IL-6 receptor IL-6R interleukin-6 Intervention literature lung Model modelling monotherapy normal predict predicted reduced reduction reflect risk SARS-COV-2 infection sequestering sIL-6R siltuximab Simulation subject subjects syndrome targets TCZ Tocilizumab treat Treatment were used [DOI] 10.1111/bcp.15009 PMC 바로가기 [Article Type] Article
High dose sofosbuvir and sofosbuvir-plus-ribavirin therapy inhibit Hepatitis E Virus (HEV) replication in a rabbit model for acute HEV infectionArticle Published on 2022-03-012023-06-11 Journal: Antiviral Research [Category] E형 간염, [키워드] combination therapy hepatitis E virus ribavirin sofosbuvir [DOI] 10.1016/j.antiviral.2022.105274
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2렘데시비르-이버멕틴 조합은 SARS-CoV-2에 대한 개선된 시험관 내 활성과 상승적인 상호작용을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: International journal of antimicrobial agents [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral activity approved Combination combination therapy combination treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CPE Cytopathic activity demonstrated drug Drug administration drug resistance effective Efficacy food greater in vitro in vitro activity in vivo Interaction Ivermectin management mechanism offer reduce Remdesivir reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support synergistic synergistic action synergy therapeutic therapeutic index to define Treatment strategies US Food and Drug Administration [DOI] 10.1016/j.ijantimicag.2022.106542 PMC 바로가기 [Article Type] Article
Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patientsResearch Article Published on 2022-02-232022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 48 hour all-cause mortality all-cause mortality rate analyzed Clinical improvement Cohort cohorts combination therapy Comparative conducted Corticosteroid COVID COVID-19 COVID-19 patient COVID-19 patients Cox proportional hazard Critically ill Efficacy groups hazard Hospitalized IMPROVE in-hospital mortality incidence Infection infections Kaplan-Meier Length log-rank test LOS monotherapy MRSA network Observational cohort study on mechanical ventilation outcome oxygen support Patient Primary outcome propensity score matching Pseudomona PSM Ratio RDV reduce reducing Remdesivir requiring supplemental oxygen secondary significant decrease Staphylococcus aureus stratified survival therapy Ventilated ventilatory support with COVID-19 [DOI] 10.1371/journal.pone.0264301 PMC 바로가기 [Article Type] Research Article
Executable network of SARS-CoV-2-host interaction predicts drug combination treatmentsArticle Published on 2022-02-142022-10-04 Journal: NPJ Digital Medicine [Category] 바이오마커, 신약개발, 치료제, [키워드] apilimod approved drugs camostat Cellular signalling networks Combination combination therapy COVID-19 pandemic COVID-19 treatment Disease progression drug combination Dynamic networks early stage effective Healthcare system human Caco-2 cells identify in silico Interaction late stage new drug combinations nine pandemic performed predict predicted Regulatory networks resource respond SARS-CoV-2-host interaction severe disease Stage target the disease Treatment viral replication Virtual drug screening [DOI] 10.1038/s41746-022-00561-5 PMC 바로가기 [Article Type] Article
Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patientsShort Communication Published on 2022-02-092022-10-31 Journal: Future Microbiology [Category] COVID-19, COVID19(2023년), SARS, [키워드] Administered average CDC clinical clinical observations Combination combination therapy controlled trials controls coronavirus COVID COVID-19 COVID-19 patient database deaths doxycycline effective Features Helicobacter pylori Hospitalization hypoxia hypoxic Ivermectin less moderate Outpatient oxygen saturation random resolved Result Safe SARS-CoV-2 subject Symptom Symptoms therapeutic therapy Treatment Vitamin Zinc [DOI] 10.2217/fmb-2022-0014 PMC 바로가기 [Article Type] Short Communication