complement system – Page 6 – Communicable Diseases Research

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

SARS-CoV-2 RNA혈증 및 단백질 궤적은 중환자실에 입원한 COVID-19 환자의 예후를 알려줍니다

Article

Published on 2021-06-072022-09-10
Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression

혈청 보체 C3 및 C4 및 COVID-19 심각도 및 사망률: 메타 회귀를 사용한 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-06-072022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] 95% CI 95% confidence interval Activation Adult patients albumin Analysis blood cell C-reactive protein C3 C4 calculated certainty certainty of evidence CIs clinical consequence complement Complement activation Complement C3 complement components complement system components Concentration conducted Continuous data coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity criteria CRP D-dimer direction disease severity effect size Egger’s tests eligibility criteria English language estimates evaluate Evidence GRADE heterogeneity magnitude measure Meta-analysis meta-regression moderate Mortality Newcastle-Ottawa Scale non-survivor Patient patients performed predict PROSPERO publication bias random-effects model Registration registration number Regression review searched sensitivity analysis serum serum concentrations severity significantly significantly lower SMD standardized mean difference study heterogeneity survival survivor systematic review Web of Science White blood cell white blood cell count
[DOI] 10.3389/fimmu.2021.696085 PMC 바로가기 [Article Type] Meta-Analysis

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19

중증 COVID19 관리를 위한 코르티코스테로이드 요법에서 비-게놈 표적으로서 인간 C5a의 역할

Article

Published on 2021-06-012022-09-12
Journal: Computational biology and chemistry [Category] MERS, SARS, 신약개발, 진단,

[키워드] activate acute respiratory syndrome amplified appear binding C3a C5a chemoattractant Circular Circular dichroism clinical evidence Colchicine combination therapy complement complement system contribute Coronavirus-2 corticosteroid therapy Corticosteroids COVID19 Cytokine storm Dexamethasone drug Effect Fluorescence globe Host immunomodulator indicate Inflammatory management moderate modulating molecular dynamics morbidity and mortality Neutralizing non-genomic non-specific pathophysiological Pathways physiological Polypharmacology positive Prednisone Prednisone. probe Prophylactic PROTECT reducing repurposing Safe SARS-CoV2 severity Signaling significantly small molecule drug triggered triggering Vaccine while
[DOI] 10.1016/j.compbiolchem.2021.107482 PMC 바로가기 [Article Type] Article

Clinical features and prognostic factors in Covid-19: A prospective cohort study

Covid-19의 임상 특징 및 예후 요인: 전향적 코호트 연구

Multicenter Study

Published on 2021-05-142022-08-31
Journal: EBioMedicine [Category] 바이오마커,

[키워드] Adhesion Molecule Admission Analysis Angiogenesis angiopoietin association Biomarker Blood CD14 cell adhesion molecule cell-cell adhesion changes in chemotaxis clinical Clinical deterioration Clinical features Coagulation Cohort complement complement component complement system Concentration Corona Corticosteroids COVID-19 COVID-19 infection Cox regression death Deterioration died Disease progression driven by End end products Endothelial dysfunction feature fibrinolysis finding funding Glycation group hospitalized patient hospitalized patients host response ICU ICU Patients IL-1-receptor IL-10 IL-6 IL-8 immunothrombosis Inflammation insight interleukin Intubated involved joint lactoferrin lead life cycle linear marker mechanisms mixed-effects models Mortality multiple pathways Necrosis outcome overlap pathway Pathway analysis Pathways Patient patients died patients with COVID-19 performed Primary outcome procalcitonin product Prognosis Prognostic factor Prognostic markers prospective cohort study receptor receptor antagonist Regulation risk severe COVID-19 therapy tissue tissue damage Tissue Factor transferred Treatment strategies Tumor tumor necrosis tumor necrosis factor urokinase Urokinase-Type Plasminogen Activator variety vascular cell adhesion VCAM-1 Viral viral life cycle ward with COVID-19 wound healing
[DOI] 10.1016/j.ebiom.2021.103378 PMC 바로가기 [Article Type] Multicenter Study

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

SARS-CoV-2는 JAK1/2 종속 국소 보체 과활성화를 유도합니다.

Research Articles

Published on 2021-04-072022-09-12
Journal: Science Immunology [Category] MERS, SARS, 진단,

[키워드] ACE activated Activation affecting Alternative pathway angiotensin angiotensin converting enzyme Antiviral blocked Bronchoalveolar lavage C3 convertase C3a Cell cell lines clinical manifestation Combination combination therapy complement Complement activation Complement C3 complement component complement system convertase coronavirus disease Coronavirus disease 2019 COVID-19 disease severity disease-causing driver drug entry receptor epithelial cell epithelial cells expressed expression Genes Gut Hyperactivation implicated induce infected cells inhibited inhibitor interferon JAK inhibitor jak inhibitors JAK1 kidney kidneys liver Local lung epithelial Lung epithelial cells Lungs lymphoid normalized not affect pathway Pathways patients processing produced Protein Remdesivir respiratory epithelial cell respiratory epithelial cells ruxolitinib SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Signaling Stat1 the disease tissues transcript Transcription underlie virus
[DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles

An update: the emerging evidence of complement involvement in COVID-19

업데이트: COVID-19에 보체 관여의 새로운 증거

Review

Published on 2021-04-032022-09-10
Journal: Medical Microbiology and Immunology [Category] MERS, 치료제,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome administration Affect affected animal models ARDS complement complement components Complement inhibitor complement inhibitors complement system component coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Defense disease Evidence form Host immune response Inflammation Inflammatory response Innate immunity kidney Kidney failure lead leads lung microbes multiorgan failure multiple organs organ damage other organ other organs outbreak potential treatment option recent respiratory distress SARS-CoV-2 Sepsis severe patients syndrome systemic inflammation tissue injury
[DOI] 10.1007/s00430-021-00704-7 PMC 바로가기 [Article Type] Review

Pharmacological approach for the reduction of inflammatory and prothrombotic hyperactive state in COVID-19 positive patients by acting on complement cascade

보체 캐스케이드에 작용하여 COVID-19 양성 환자의 염증성 및 전혈전성 과잉활성 상태의 감소를 위한 약리학적 접근

Review

Published on 2021-04-012022-09-12
Journal: Human immunology [Category] MERS, SARS, 진단, 치료제,

The roles and potential therapeutic implications of C5a in the pathogenesis of COVID-19-associated coagulopathy

Review

Published on 2021-04-012023-07-13
Journal: Cytokine & growth factor reviews [Category] SARS,

[키워드] anaphylatoxin C5a complement system COVID-19-associated coagulopathy Pathogenesis
[DOI] 10.1016/j.cytogfr.2020.12.001 PMC 바로가기 [Article Type] Review

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

보완 과잉 활성화 및 소비는 SARS-CoV-2 감염의 병원 내 사망률을 예측합니다

Clinical Trial

Published on 2021-03-252022-08-13
Journal: Frontiers in Immunology [Category] SARS, 임상,

[키워드] 95% CI accompanied Activation advanced disease analyzed anaphylatoxin anaphylatoxin C3a C-reactive protein C3a/C3 caused characteristic classical pathways clinical complement Complement activation complement activation and consumption complement inhibitory drug complement inhibitory drugs complement profile complement system Consumption coronavirus coronavirus disease coronavirus disease (COVID-19) covariate COVID-19 COVID-19 related mortality COVID-19 severity Cox model decrease enzyme-immunoassays Evidence Factors ferritin hemolytic hemolytic titration hospital Hospital stay Hospitalized hospitalized COVID-19 patients implicated In-hospital in-hospital mortality Increased Inflammation interleukin interleukin-6 marker Mortality objective Ordinal Scale outcome Outpatient overactivation Pathogenesis patients died PCR-confirmed COVID-19 predictor Primary outcome prospective cohort study Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus secondary outcome severity severity of COVID-19 significantly Support the disease the WHO Thromboinflammation Treatment treatment of COVID-19 turbidimetry uncontrolled were measured WHO ordinal scale
[DOI] 10.3389/fimmu.2021.663187 PMC 바로가기 [Article Type] Clinical Trial

MASPs at the crossroad between the complement and the coagulation cascades – the case for COVID-19

Articles

Published on 2021-03-172022-10-31
Journal: Genetics and Molecular Biology [Category] COVID-19,

[키워드] Activation antibody Arterial hypertension association Atypical binding Biomarker Blood coagulation cardiovascular disease cascades Cerebrovascular disease Chronic kidney disease chronic obstructive Coagulation coagulation cascade Comorbidity complement complement system component COVID-19 COVID-19 patient COVID-19 patients diabetes Diseases Efficiency encoded proteins functional highlight in viral increased expression Inflammation inhibitor lectin pathway mannose MASP MASP-2 MASP1 MASP2 modulating new treatment strategy parameter patients with COVID-19 positive result progression pulmonary disease reported risk serine protease severity subsequent susceptibility therapeutic target variant
[DOI] 10.1590/1678-4685-GMB-2020-0199 PMC 바로가기 [Article Type] Articles