Preprints in times of COVID19: the time is ripe for agreeing on terminology and good practicesDebate Published on 2021-07-282022-10-28 Journal: BMC Medical Ethics [Category] Coronavirus, Fulltext, SARS, [키워드] Community complexity Consensus Consequences COVID19 dissemination FIVE help include increase increasingly information International manuscript media non-peer reviewed over peer peer-reviewed raise Research research finding research findings submitted terminology thought [DOI] 10.1186/s12910-021-00667-7 PMC 바로가기 [Article Type] Debate
Leveraging Artificial Intelligence and Big Data to Optimize COVID-19 Clinical Public Health and Vaccination Roll-Out Strategies in Africa인공 지능과 빅 데이터를 활용하여 아프리카의 COVID-19 임상 공중 보건 및 백신 출시 전략 최적화Editorial Published on 2021-07-262022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, [키워드] Africa African amplify Analysis artificial artificial intelligence big data clinical complexity country COVID-19 develop economic costs effective Effectiveness equity Health Innovation intelligence National pandemic parameters Public public health Strategy the vaccine Vaccination strategies Vaccination strategy Vaccine vaccine roll-out variants variants of concern VoC while [DOI] 10.3390/ijerph18157890 PMC 바로가기 [Article Type] Editorial
Precision omics data integration and analysis with interoperable ontologies and their application for COVID-19 research상호 운용 가능한 온톨로지와 COVID-19 연구에 대한 응용을 통한 정밀 오믹스 데이터 통합 및 분석Article Published on 2021-07-172022-09-11 Journal: Briefings in functional genomics [Category] SARS, 유전자 메커니즘, [키워드] accompanied Analysis artificial intelligence Biomedical research complexity conditions COVID-19 COVID-19 research Critical Data analysis disease Disease diagnosis effective Effectiveness genetics heterogeneous hypothese hypotheses Hypothesis implementation integration interoperability knowledge machine learning mechanism Metadata molecular molecular mechanism molecular mechanisms omics omics technologies ontologies Ontology outcome outcomes Phenotypes positively correlated Precision precision medicine precision omics. provided rationale required Research Standardization Support supported term translate Treatment underlying disease Usage use case [DOI] 10.1093/bfgp/elab029 PMC 바로가기 [Article Type] Article
The Investigational Clinical Center: a clinical-supportive and patient-centered trial unit model. Ten years of experience through normal and pandemic times of a large pediatric trial center in ItalyInvestigational Clinical Center: 임상 지원 및 환자 중심 시험 단위 모델. 이탈리아의 대규모 소아 임상 센터에서 정상 및 유행성 시기에 걸친 10년의 경험Letter to the Editor Published on 2021-07-132022-09-10 Journal: Italian Journal of Pediatrics [Category] SARS, 임상, [키워드] activities affected best center children clinical Clinical management Clinical research clinical trial Clinical trial unit clinical trials clinician Complete complexity Compliance conducted COVID-19 pandemic Efficacy and safety engage enrolled evaluated Evidence-based medicine feature Good Good Clinical Practice helping ICC implementation include investigator investigators Italy legal guardian majority management Metrics off-label offer overcome pandemic parent parents Patient pediatric Pediatric clinical research pediatrics pharmacological Practice principal investigator Principal Investigators rare diseases recruitment reported Research Research staff Rome supplementary material Support Treatment Trial Trial implementation Trial management unit [DOI] 10.1186/s13052-021-01099-0 PMC 바로가기 [Article Type] Letter to the Editor
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern에피토프 특이적 항체 반응으로 COVID-19 결과와 우려 변종 차별화Clinical Medicine Published on 2021-07-082022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료법, [키워드] Action antibody antibody profiling Antibody Response Antibody responses Antibody testing Antigen antigens B.1.1.7 Clinical outcome Clinical severity complex complexity coronavirus COVID-19 detect develop epitope epitope peptide Epitopes foundation Health Sciences high resolution High-resolution Humoral immunity identify immunoassay immunoglobulins Infection Infectious disease Innovation linear epitope linear epitopes London Microarrays Mutation N protein Neutralizing Neutralizing antibodies Non-neutralizing antibodies nucleocapsid ORF organization outcome P681H patient survival peptide peptides plasma sample plasma samples positively correlated predict produced Protein Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome Science screened serology test serology tests specificity the SARS-CoV-2 Toronto university variant variants variants of concern [DOI] 10.1172/jci.insight.148855 PMC 바로가기 [Article Type] Clinical Medicine
Reimagining the peer-review system for translational health science journals중개적 건강 과학 저널을 위한 피어 리뷰 시스템 재구상Review Published on 2021-07-012022-09-11 Journal: Clinical and translational science [Category] SARS, 임상, [키워드] addition approach authors benefit build can not collective complexity coronavirus disease Coronavirus disease 2019 COVID-19 creating Effectiveness England expected Forum generate groupthink Health Science individual initial reaction journal knowledge Lancet limitation manuscript media Medicine New peer review Research Retraction the mean translate translational Translational research [DOI] 10.1111/cts.13050 PMC 바로가기 [Article Type] Review
Padlock probe-based rolling circle amplification lateral flow assay for point-of-need nucleic acid detection필요 시점 핵산 검출을 위한 자물쇠 프로브 기반 롤링 서클 증폭 측면 유동 분석Article Published on 2021-06-282022-09-11 Journal: The Analyst [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome amplification Analysis antimicrobial resistance Bacterial binding site biosafety can be used cleave complex complexity Culture diagnostics digestion DNA DNA and RNA double-stranded environmental monitoring Epidemiology faster food safety help inherent isothermal isothermal amplification method isothermal amplification methods lateral flow lateral flow immunoassay limit limit of detection linear NAAT Novel coronavirus Nuclease nucleic acid nucleic acid amplification tests Nucleic acid detection padlock pathogen Pathogens PCR plan platform polymerase probe provide RCA reaction referred to resistance gene respiratory robustness Rolling circle amplification Saliva SARS-CoV-2 sensitive Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 significantly single-stranded DNA targets Therapeutics tissue extract turnaround time water [DOI] 10.1039/d1an00399b PMC 바로가기 [Article Type] Article
Why should HCWs receive priority access to vaccines in a pandemic?Debate Published on 2021-06-272022-10-28 Journal: BMC Medical Ethics [Category] COVID-19, Fulltext, MERS, SARS, [키워드] addition complexity coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines Deontology distribution effective evaluate example Government HCW HCWs Health authority healthcare Healthcare resource allocation healthcare worker pandemic Pandemics Policy question receive Reciprocity resources Topic Utilitarianism Vaccine Vaccines [DOI] 10.1186/s12910-021-00650-2 PMC 바로가기 [Article Type] Debate
High-Surety Isothermal Amplification and Detection of SARS-CoV-2SARS-CoV-2의 고정밀 등온 증폭 및 검출Research Article Published on 2021-05-192022-09-10 Journal: mSphere [Category] SARS, 진단, 치료기술, 치료제, [키워드] absence accumulate addition Amplicon amplicons amplification analyte approach assays binding Boolean logic carried changes complexity COVID-19 described detection diagnostics Diseases employment False negative false negatives False positives false-negative false-negative results False-positive results Fluorescence generate gold gold standard help human resource human saliva Inclusion inefficient Infectious diseases isothermal isothermal amplification isothermal nucleic acid diagnostics LAMP lateral flow Lateral flow assays lead Loop-mediated isothermal amplification maintain Molecular assay multiplex multiplex assays Mutation non-sequence-specific nonspecific nucleic acid nucleic acid amplification pathogen Pathogens point-of-care primer probe probes qPCR quantitative PCR reduce redundancy Region resource resulting SARS-CoV-2 SARS-CoV-2 virion SARS-CoV-2 virions Scaling sequence simplicity strand displacement probes target targets Treatment [DOI] 10.1128/mSphere.00911-20 PMC 바로가기 [Article Type] Research Article
One-Stop Serum Assay Identifies COVID-19 Disease Severity and Vaccination Responses원스톱 혈청 분석으로 COVID-19 질병 심각도 및 백신 접종 반응 확인Article Published on 2021-05-172022-09-11 Journal: ImmunoHorizons [Category] SARS, 진단, 치료법, [키워드] Adults Anti-RBD IgG Antiviral binding domain caused characterization complexity Comprehensive Concentration convalescent COVID-19 patient COVID-19 COVID-19 vaccine COVID-19 vaccines Critical death Diagnosis differentiation disease domain healthy IgA IgG IgG level IgG levels IgM Immunity immunoassay infections Kinetics magnitude measure measurement Mild mRNA COVID-19 vaccines multiplex N protein N-terminal domain neutralization Patient patients plasmablast responses Previous studies prozone RBD reached Receptor binding domain response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid sera serum serum/plasma severe disease severity symptom onset the N protein [DOI] 10.4049/immunohorizons.2100011 PMC 바로가기 [Article Type] Article