The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기
Microbiome Analysis for Wastewater Surveillance during COVID-19Article Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Analysis association Bacteria can be used carried cell entry circulating collected communicable diseases Community Composite Concentration conditions contagious diseases contributing to correlated COVID-19 D1118H D614G detect DNA DNA and RNA DNA sequencing drastic Environmental risk Factors fungi genetic mutation genetic mutations Health identify incidence incidence of COVID-19 increase in individual infected individuals information K417N metagenome metagenomics Metatranscriptomics microbial Microbiome microorganism molecular nasal swab offer Outbreaks P681H pathogen pathogenic agent provide provided public health Real-time monitoring reflected Reinfection resistance genes Result risk Risk assessment RNA RNA sequencing RT-qPCR S982A Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 sequencing selected Sequencing shotgun sequencing Specific structures Surveillance T716I temperature transmission of SARS-CoV-2 Treatment USA viruses wastewater wastewater monitoring wastewater surveillance Wastewater-based epidemiology whole metagenome sequencing. [DOI] 10.1128/mbio.00591-22 PMC 바로가기
Current trends and outcomes of non-elective neurosurgical care in Central Europe during the second year of the COVID-19 pandemic Research Published on 2022-08-272022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 30-Day mortality Brain Care Community condition conditions counseling country COVID-19 COVID-19 pandemic current Czech Republic deleterious effect driven by etiology Europe First wave Health hematoma incidence incidence rate Injury morbidity Mortality Non-COVID-19 outcome pandemic Patient Prevalence primary analysis reduced reflect Reflecting significantly [DOI] 10.1038/s41598-022-18426-y [Article Type] Research
The inter-relationship between delirium and dementia: the importance of delirium prevention Reviews Published on 2022-08-262022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 임상, 치료법, [키워드] accelerate adverse outcomes Biomarkers cause characterized cognitive Cognitive impairment complex conditions confusional connection delirium Dementia dysfunction Evidence functional General population higher risk incidence independent risk factor individual Intervention mechanism Occurrence Older pathophysiology Prevent reduce review risk factor subsequent trajectory Treatment [DOI] 10.1038/s41582-022-00698-7 [Article Type] Reviews
Characteristics of Reported Deaths Among Fully Vaccinated Persons With Coronavirus Disease 2019-United States, January-April 20212019-미국, 2021년 1월-4월 코로나바이러스 질병에 대한 완전한 예방접종을 받은 사람 중 보고된 사망의 특성Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered analyzed B.1.1.7 breakthrough Care center characterized completion conditions Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases dead death deaths died disease control eligible Health health condition Infection Lineage Long-term care measure median age mitigate no difference no differences occur Older Older age outcome Patient Person positive postvaccination prevention remained reported risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 test sequenced severe acute respiratory syndrome Coronavirus severe disease specimen Surveillance test result vaccinated against COVID-19 vaccination Vaccine [DOI] 10.1093/cid/ciac066 PMC 바로가기 [Article Type] Article
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in animal models오일 기반 보조제의 스쿠알렌은 SARS-CoV-2 RBD의 면역원성을 개선하고 동물 모델에서 안전성을 확인합니다Article Published on 2022-08-232022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] accelerated adjuvant Analysis animal model assays binding Cellular immune response Chromatography conditions COVID-19 demonstrated determine determined by elicited ELISA etiologic agent evaluated expressed flow cytometry Formulation hamsters histopathological humoral immune immunization immunogenicity IMPROVE insect cell insect cells kidney lead liver Lungs mice Neutralizing antibodies neutralizing antibody pandemic Protein purified RBD of SARS-CoV-2 RBD protein receptor Safe SARS-CoV-2 SARS-CoV-2 RBD sera shown squalene stimulate sub-unit vaccine the Spike Vaccine vaccine candidate variant virus water [DOI] 10.1371/journal.pone.0269823 PMC 바로가기 [Article Type] Article
Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 AntigenSARS-CoV-2 항원의 민감한 파지 기반 효소 연결 화학발광 면역분석을 위한 SARS-CoV-2 스파이크 S1 단백질에 특이적으로 결합하는 파지 펩티드의 발견Article Published on 2022-08-232022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] albumin Amino acid amino acid sequence amplification antigen recognition binding site bovine bovine serum albumin chemiluminescence immunoassay conditions COVID-19 pandemic detect diagnose Dissociation constant Economy Effect exhibited expressing healthcare high affinity hydrogen hydrogen bond network hydrophobic immunoassay Interaction molecular docking N-terminal domain peptide peptides phage probe Protein pseudovirus S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S1 SARS-CoV-2 S1 protein selective sensitive sensitivity serum albumin specificity spike Spread supported target target protein the S1 subunit the SARS-CoV-2 transducing transmembrane protein [DOI] 10.1021/acs.analchem.2c01988 PMC 바로가기 [Article Type] Article
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations Research Published on 2022-08-222022-10-05 Journal: Nature Communications [Category] 바이오마커, 치료법, [키워드] acute phase reactant adverse outcome approach caused cellular change Co-regulation conditions COVID-19 death defined Elevation growth hospitalized patients Human Infection Inflammation Inflammatory Ischemia laboratory measurement linear mechanism Myocardial infarction pathologic Platelet Population provide risk Sepsis tissue damage trajectory trauma WBC White blood cell [DOI] 10.1038/s41467-022-32222-2 [Article Type] Research
Summary of Guidance for Minimizing the Impact of COVID-19 on Individual Persons, Communities, and Health Care Systems – United States, August 2022Article Published on 2022-08-192022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료제, [키워드] acute illness age Antiviral agents approach Care cause CDC changes in circulating variants conditions COVID-19 COVID-19 illness current death effective effort expand exposure Health high risk Hospitalization Immunity Immunocompromised Impact increase individual Infection information Mask measure Measures medical condition monoclonal antibodies nonpharmaceutical intervention Nonpharmaceutical interventions preexposure prophylaxis Prevent PROTECT public health receive recommendation reduce reduced reducing Respirator risk SARS-CoV-2 symptomatic System therapeutic Treatment United States vaccination Vaccine Vaccines Ventilation virus [DOI] 10.15585/mmwr.mm7133e1 PMC 바로가기
Reliability of predictive models to support early decision making in the emergency department for patients with confirmed diagnosis of COVID-19: the Pescara Covid Hospital scoreCOVID-19 진단이 확인된 환자의 응급실에서 조기 의사 결정을 지원하는 예측 모델의 신뢰성: Pescara Covid Hospital 점수Article Published on 2022-08-192022-09-11 Journal: BMC health services research [Category] 변종, [키워드] Abruzzo Accuracy Admission age and gender Algorithm Alpha build calibrated can be used carried Characteristics clinical decision collecting data conditions COVID-19 D-dimer death decision Decision making diabete diabetes diagnosed with COVID-19 Diagnosis disease distribution emergency department heterogeneous higher risk hospital hospital management hospitalisation identify independent predictor independent predictors initial intensive care Italy laboratory parameter Laboratory parameters Lactate lactate dehydrogenase Logistic regression monocyte other variant other variants outcome oxygen oxygen support pandemic parameter Patient patients with COVID-19 prediction Prediction score Predictive model predictive models predictor procalcitonin Prognosis renal renal disease Retrospective study risk Risk scores risk stratification saturation significantly Support survival threshold validation variants of concern virus were used [DOI] 10.1186/s12913-022-08421-4 PMC 바로가기 [Article Type] Article