Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles VLPs VOCs [DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article
Soluble CD137 as a potential biomarker for severe COVID-19Article Published on 2022-08-012022-10-05 Journal: Immunology letters [Category] 바이오마커, [키워드] 24 hour acute respiratory syndrome Analysis Biomarker Blood Brazil Care caused CD137 characterized Clinical outcome contagious Control coronavirus Coronavirus disease 2019 correlation COVID-19 critical COVID-19 patient Critically ill patient cytokine Cytokines demonstrated disease disease severity evaluate evaluated growth factor Growth factors Health healthy blood donors high risk highly pathogenic hospital ICU ICU admission identify immune increase in increased risk Infection intensive care isoform mechanical ventilation membrane-bound mortality rate Necrosis outcomes pandemic Potential biomarker potential therapy primary endpoint Prospective Study receptor recruitment regulate responsible SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity Soluble CD137 Soluble immune checkpoints T-cell activation therapeutic targets TNF was related was used WHO with COVID-19 World Health Organization [DOI] 10.1016/j.imlet.2022.07.003 [Article Type] Article
Computational repurposing approach for targeting the critical spike mutations in B.1.617.2 (delta), AY.1 (delta plus) and C.37 (lambda) SARS-CoV-2 variants using exhaustive structure-based virtual screening, molecular dynamic simulations and MM-PBSA methods철저한 구조 기반 가상 스크리닝, 분자 역학 시뮬레이션을 사용하여 B.1.617.2(델타), AY.1(델타 플러스) 및 C.37(람다) SARS-CoV-2 변이체에서 중요한 스파이크 돌연변이를 타겟팅하기 위한 전산 용도 변경 접근 방식 및 MM-PBSA 방법Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 approach Area atovaquone AY.1 B.1.617.2 binding affinity binding site candidate causative agent complex complexes Compound contagious contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Delta delta variant Delta variants docking result docking results drug Drug repurposing drug-likeness drugs eight enzyme FDA approved drug FDA approved Drugs followed by genomic help heparin highest binding affinity Host hydrogen Hydrogen bond identify in silico inhibiting inhibitor inhibitors interact Interaction interactions Lambda Ligand MD simulation MD simulations molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics morbidity and mortality mortality rates Mutation mutations Praziquantel Protein Proteins RBD Receptor-binding domain reported Research researcher residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike spike mutation Spike protein stability surface surface area targets the receptor-binding domain the spike protein variant variants variants of concern viral cell Virtual screening VoC was done was performed wild type Wuhan Wuhan, China [DOI] 10.1016/j.compbiomed.2022.105709 PMC 바로가기 [Article Type] Article
Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq이라크에서 SARS-CoV-2의 델타 변이체와 비교하여 새로 출현한 오미크론 변이체의 스파이크 단백질의 분자 및 컴퓨터 분석Article Published on 2022-08-012022-09-11 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome coronavirus Affect amino acids angiotensin angiotensin converting enzyme binding affinity bioinformatics computational analysis computational tool computational tools concerning contagious contributing to COVID-19 Delta delta variant Delta variants disorder Docking studies docking study engage enzyme greater Health higher affinity human ACE2 human angiotensin converting enzyme 2 hydrophobic amino acid identify Interaction Iraq less molecular molecular docking omicron Omicron variant Omicron variants pathogenicity PCR Phylogenetic analysis physical physical and chemical properties predicted qPCR RBD RBD region Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Spike protein stability the spike protein Transmissibility Transmission Vaccine variant variant of SARS-CoV-2 variants variants of concern virus were used WHO [DOI] 10.1007/s11033-022-07545-4 PMC 바로가기 [Article Type] Article
MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
Plasmonic Approaches for the Detection of SARS-CoV-2 Viral ParticlesSARS-CoV-2 바이러스 입자 검출을 위한 플라즈몬 접근법Review Published on 2022-07-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody treatment applicability approach Care caused contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detection diagnostic diagnostic testing diagnostics focus genetic material highlight Highlights Infection infectivity testing neutralizing antibody non-infected nucleocapsid outbreak pandemic Particle Patient platform POCT point-of-care point-of-care testing Protein provided respiratory reverse transcription PCR RT-PCR S1 protein SARS-CoV-2 SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARSC-CoV-2 severe acute respiratory syndrome Coronavirus spike glycoprotein spike glycoproteins Spike protein SPR structural proteins surface plasmon surface plasmon resonance surface plasmonic resonance (SPR). the S1 protein therapeutic Treatment Vaccine Viral viral particle Viral particles Viral protein virus while [DOI] 10.3390/bios12070548 PMC 바로가기 [Article Type] Review
Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients Research Published on 2022-07-132022-10-05 Journal: Cell Death Discovery [Category] 치료법, [키워드] activated Activation acute respiratory distress acute respiratory syndrome addition approach ARDS avoidance caused contagious Control cough COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Critical cytokine production Cytokine storm death develop early response effective exacerbated Fever hospitalized patient IL-6 immune response immune system implication in viral include increase in induce Infection inhibition MCP-1 mechanism modulation mononuclear cell pathology Patient patients PBMCs Peripheral blood Pneumonia post-translational modification previous study proliferation Protein proteome reached reduce regulate SARS-CoV-2 serum severe pneumonia stability subsequent syndrome systemic inflammation therapeutic Vaccine viral infection [DOI] 10.1038/s41420-022-01115-0 [Article Type] Research
Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic reviewSARS-Cov-2 오미크론 변이체에 대한 COVID-19 백신의 체액 및 세포 면역 반응: 전신 검토Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.529 booster booster dose cellular Cellular immune response cellular immune responses center contagious coronavirus 2 country COVID-19 vaccine Critical current dominant variant dose Effectiveness elicit elicited Future Genome Health Organization Heterologous homogenous homologous or heterologous humoral Humoral and cellular immune responses humoral immune response humoral immune response, cellular immune response immune Immune escape immune responses induce molecular basis multiple mutation multiple mutations mutated Mutation Neutralizing antibody response neutralizing antibody responses omicron Omicron variant PROTECT Protective public health question regimen regimens reported respiratory response robust S-protein SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Systemic review systemically T cell T cell response the SARS-CoV-2 virus vaccination Vaccination strategy Vaccine variant VoC WHO World Health Organization [DOI] 10.7150/ijbs.73583 PMC 바로가기 [Article Type] Review
Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy예방 접종 및 변종: 이탈리아의 Covid-19 진화에 대한 회고 모델Article Published on 2022-07-082022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] absence appearance changes characterized combined effect compartmental model contagious COVID-19 pandemic deaths decreases delta variant develop dominant effective Effects epidemiological Evolution followed by individual induce Infection Italy measure mechanism mechanisms normality omicron Omicron variant pandemic Particular predict Retrospective analysis seasonal variation stability vaccination Vaccine Variability variant Variation virus virus infectivity waning immunity [DOI] 10.1371/journal.pone.0265159 PMC 바로가기 [Article Type] Article
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2SARS-CoV-2에 대한 인간 신경모세포종 세포의 전사적 풍경Article Published on 2022-07-062022-09-11 Journal: BMC neuroscience [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applied approach Cell cells Central nervous system changes in chemokines contagious coronavirus Cytokines decrease differentially expressed gene Differentially expressed genes downregulated function functions Gene ontology host mRNA identify Infection Injury involved knowledge Kyoto mechanism mRNA mRNAs Neuroinflammation Neurological symptom Neurological symptoms NF-κB pathogenic Pathways Patient performed receptors reported RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly SK-N-SH cells. transcriptional profile transcriptional profiles transcriptomic Treatment upregulated [DOI] 10.1186/s12868-022-00728-6 PMC 바로가기 [Article Type] Article