Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concernArticle Published on 2021-10-192022-10-04 Journal: Cell Discovery [Category] 변종, 유전자 메커니즘, 치료제, [키워드] absence Analysis antibody approved B cell B.1.1.7 B.1.351 B.1.617 Biological techniques candidate circulating SARS-CoV-2 variant Combination contribute Convalescent patients drug dual combination Human monoclonal antibody immunology in vitro in vivo Lung pathology NAb Neutralizing pandemic Prevent prevention of COVID-19 proportion Research risk SARS-CoV-2 SARS-CoV-2-infected hamsters SARS-CoV-2-neutralizing antibody suppress therapeutic Treatment variants viral escape viral replication viral variant Viral variants virus-neutralizing [DOI] 10.1038/s41421-021-00340-8 PMC 바로가기 [Article Type] Article
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans건강한 성인에서 SARS-CoV-2에 대한 BBIBP-CorV(Sinopharm) 및 BNT162b2(Pfizer-BioNTech) 백신에 의해 유도된 항체 및 T 세포 반응의 비교Original Article Published on 2021-10-112022-09-11 Journal: GeroScience [Category] MERS, SARS, 치료법, [키워드] adaptive Adaptive immunity Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies Anti-spike antibody BBIBP-CorV BNT162b2 cell-mediated immune response Cell-mediated immune responses Convalescent patients cumulative domain effective elicit elicited epitope Epitopes evaluate healthy healthy individuals Human humoral IFNγ ELISpot assay IFNγ-producing T cells IFNγ IgA antibodies IgA antibody IgG immune response immune responses Immunity immunologically in healthy individuals inactivated injected investigated Live virus membrane mRNA mRNA vaccine mRNA-based much lower nucleocapsid participant pattern Pfizer-BioNTech Protein Proteins Quantitative RBD S protein epitopes SARS-CoV-2 SARS-CoV-2 virus Sinopharm supplementary material T cell T cell response target the S protein These data vaccination Vaccine virus Volunteer [DOI] 10.1007/s11357-021-00471-6 PMC 바로가기 [Article Type] Original Article
Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months6개월 동안 입원부터 회복까지 COVID-19 환자의 SARS-CoV-2 유도 체액 면역 반응의 지속 가능성Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] MERS, SARS, 진단, 치료기술, [키워드] acquired immunity age all the patients analyzed anti-SARS-CoV-2 antibody capture chemiluminescence immunoassay CLIA convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 antibody COVID-19 patient COVID-19 symptoms detect dynamic exhibit Gender group help herd immunity Hospitalization Hospitalized humoral immune response humoral responses IgG antibody IgM IgM antibodies IgM/IgG Immunity induced investigated Month N protein observation over Patient peaked persistence positive Receptor binding domain reduced reducing Reinfection response retrospective cohort study risk S protein SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severity specimen sustainability sustained the patient titers titers of IgG understanding undetectable vaccination Wuhan [DOI] 10.1007/s12250-021-00360-4 PMC 바로가기 [Article Type] Article
Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 VariantsSARS-CoV-2 변이체에 대한 광범위 중화 항체Review Published on 2021-09-272022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha antibody B.1.1.7 B.1.351 B.1.617.2 Beta breadth broadly neutralising antibodies CDR Characteristics Containment convalescent patient Convalescent patients coronavirus cross-neutralization cross-neutralize Delta delta variant development Effect effective escape mutants function Gamma mAb mAbs monoclonal antibodies monoclonal antibody Neutralizing Neutralizing antibodies neutralizing antibody pandemic Patient plasma priority reduced respiratory Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variants sensitivity sera severe acute respiratory syndrome Coronavirus shown therapeutic therapeutic antibodies understanding vaccinated individuals Vaccines variant variants variants of SARS-CoV-2 virus [DOI] 10.3389/fimmu.2021.752003 PMC 바로가기 [Article Type] Review
Sensitivity of SARS-CoV-2 Variants to Neutralization by Convalescent Sera and a VH3-30 Monoclonal Antibody회복기 혈청 및 VH3-30 단클론항체에 의한 중화에 대한 SARS-CoV-2 변이체의 민감도Immunology Published on 2021-09-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response B.1.1.7 B.1.351 B.1.617.1 binding activity Brazil caused collected convalescent patient Convalescent patients convalescent sera coronavirus coronavirus disease COVID-19 global pandemic India indicated Intervention mAb mAbs Medical countermeasures neutralization neutralizing capacity neutralizing mAb neutralizing monoclonal antibodies neutralizing monoclonal antibody New Novel coronavirus novel coronavirus disease P.1 pandemic respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus South Africa Spread Vaccine variants VH3-30 VoC VOCs wild-type [DOI] 10.3389/fimmu.2021.751584 PMC 바로가기 [Article Type] Immunology
Kinetics of SARS-CoV-2 Specific and Neutralizing Antibodies over Seven Months after Symptom Onset in COVID-19 PatientsResearch Article Published on 2021-09-222022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval acute phase acute respiratory syndrome administration age anti-SARS-CoV-2 antibody antibodies antibody Characteristics China collected conducted convalescent COVID-19 patient Convalescent patients coronavirus coronavirus disease COVID-19 COVID-19 convalescent patient COVID-19 patient Dilution discharge discharged disease severity enrolled Evidence Factor Follow-up follow-up period follow-up time geometric mean titer GMT hospital IgG IgM IgM/IgG immune response inhibitory interquartile range Jiangsu Kinetics male median Month natural infection Neutralizing activity neutralizing antibody Onset participant Patient patients persistence plasma sample produced SARS-CoV-2 serological seropositive serum sample severity significantly higher significantly lower Specific Standard deviation symptom onset tested Vaccine virus dynamics with COVID-19 [DOI] 10.1128/Spectrum.00590-21 PMC 바로가기 [Article Type] Research Article
Profound Treg perturbations correlate with COVID-19 severity420 Published on 2021-09-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] Antiviral Complication contribute Convalescent patients COVID-19 COVID-19 pathology detrimental dysfunction effectors excessive inflammation expression FOXP3 hallmark IL-18 IL-6 Immune homeostasis immunological increase in Inflammatory response MOST notable outcomes overexpression Patient Perturbation perturbations phenotype poor prognosis proinflammatory proinflammatory mediators proinflammatory molecule proportion proportions Regulatory T cell responses responsible resulting severe COVID-19 severe COVID-19 patients severe disease Severe patient severity Significance similarity suppress T cell response T regulatory cell the disease these cell transcription factor transcriptional transcriptomic Treg Tregs tumor Tregs with COVID-19 [DOI] 10.1073/pnas.2111315118 PMC 바로가기 [Article Type] 420
Neutrophil Maturation, Reactivity and Granularity Research Parameters to Characterize and Differentiate Convalescent Patients from Active SARS-CoV-2 InfectionArticle Published on 2021-09-062022-10-31 Journal: Cells [Category] COVID-19, [키워드] change convalescent convalescent patient Convalescent patients Coronavirus 2019 COVID-19 COVID-19 disease disease granularity groups healthy control help highest immune response Infection innate immune response leukopenia lowest median morphological parameters neutrophil neutrophil activation Neutrophils neutrophils granularity index New parameter Pathogenesis Patient positive RT-PCR proportion reactivity of neutrophils SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection study group Volume [DOI] 10.3390/cells10092332 PMC 바로가기 [Article Type] Article
Mouth Washing Impaired SARS-CoV-2 Detection in SalivaArticle Published on 2021-08-222022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] cellular collected Concordance Convalescent patients coronavirus COVID-19 COVID-19 diagnosis demonstrated detection diagnose diagnosed Follow-up France Germany healthcare worker homogeneous hospitals Impaired impairment imperative individual kinetic molecular mouth Nasopharyngeal swab Non-invasive NPs Outpatient patients positive RNA extraction RNase P RT-qPCR Saliva saliva specimen saliva specimens saliva test SARS-CoV-2 SARS-CoV-2 detection sensitivity symptomatic and asymptomatic the patient turn Viral load virus washing [DOI] 10.3390/diagnostics11081509 PMC 바로가기 [Article Type] Article
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection면역 체크포인트 억제제는 SARS-CoV-2 감염 동안 T 세포 면역을 증가시킵니다Research Article Published on 2021-08-182022-09-12 Journal: Science Advances [Category] MERS, SARS, 진단, 치료법, [키워드] adaptive Alter Antiviral CD8 cellular Cohort convalescent convalescent patient Convalescent patients COVID-19 COVID-19 pandemic COVID-19 patients demonstrated effector memory Evidence exacerbating expansion immune Immune checkpoint inhibitor Immune checkpoint inhibitors Immunity IMPROVE Infection Inflammation Inflammatory inhibitor interferon investigated Melanoma membrane nucleoprotein Patient profiles proteomic responses SARS-COV-2 infection severe COVID-19 Spike-specific antibody Spike-specific antibody responses Spread T cell T cell activation T cell response T cells transcriptomic treated Treatment type I interferon [DOI] 10.1126/sciadv.abg4081 PMC 바로가기 [Article Type] Research Article