Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine DevelopmentReview Article Published on 2020-07-182022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] against SARS-CoV animal model Antigen candidate coronavirus Coronavirus infection coronavirus spike protein coronavirus vaccine COVID-19 develop development effective facilitate Genetic global health security help highly pathogenic induce lesson neutralizing antibody novel coronavirus disease outbreak pathogenic coronavirus protective immunity respiratory SARS-CoV SARS-CoV-2 similarity spike subunit the vaccine Vaccine vaccine candidate virus [DOI] 10.1155/2020/7201752 PMC 바로가기 [Article Type] Review Article
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계Immunology Published on 2020-07-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상, [키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected [DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology
Universal coronavirus vaccines: the time to start is nowComment Published on 2020-05-282022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome coronavirus coronavirus vaccine effort help Immunity Influenza Influenza virus International Novel coronavirus outbreak public health measure SARS-CoV-2 similarity Spread triggered Universal Vaccine Vaccine design Vaccine development Vaccines viral infection [DOI] 10.1038/s41541-020-0198-1 PMC 바로가기 [Article Type] Comment
Certainty of success: three critical parameters in coronavirus vaccine developmentReview Article Published on 2020-05-252022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] biological parameter certainty circulating coronavirus vaccine Coronavirus vaccines COVID-19 vaccine Critical death disease effective Efficacy force of infection humans Incubation period intensity pandemic parameter pathogen predicted Protective reduce SARS-CoV-2 SARS-COV-2 infection severity turn Vaccine Vaccine development Vaccines viral infection viral pathogen virus [DOI] 10.1038/s41541-020-0193-6 PMC 바로가기 [Article Type] Review Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article