Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationResearch Article Published on 2021-12-062022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Anti-viral approach Cell contribute contributed coronavirus Coronavirus replication CoV CoV infection CoV replication CoVs CRISPR CRISPR screen Critical disease disease pathogenesis effort Evidence Factor gastroenteritis Health highly pathogenic CoVs Host host gene identification identify Infection inhibit involved kidney performed potential therapeutic target progression Protein provide regulate Replication required reveal RNA virus RNA viruses susceptibility TGEV therapeutic target Tmem41b Vesicle viral infection virus virus replication [DOI] 10.1371/journal.ppat.1010113 PMC 바로가기 [Article Type] Research Article
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication423 Published on 2021-11-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding [DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423
The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine CoronavirusPathogenesis and Immunity Published on 2021-11-242022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] Accessory accessory protein accessory protein 8b accessory proteins addition Affect antiviral immune response beta coronavirus C-terminal contribute coronavirus CoV CoVs demonstrated ENCODE Endoplasmic reticulum ENhance enhanced Essential expressing FIVE Genome global public health Hepatitis high variability Host IFN-I in vitro in vivo infected cells inhibit inhibitory effect innate immune response Innate immunity interfere introduced membrane MERS-CoV MERS-CoV infection methionine MHV mice Middle East mouse mouse hepatitis virus Multiple murine N-terminal domain not affect ORF8b Pathogenesis Protein protein 3 Region regulate renal Replication respiratory respiratory syndrome coronavirus responsible RNA-seq analysis SARS-CoV SARS-CoV-2 severe pneumonia severe respiratory infection shown significantly threat type I interferon variant viral replication Viral virulence virulence virus [DOI] 10.1128/JVI.01842-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19천연 생리활성 분자: COVID-19의 치료 및 통제에 대한 대안적 접근Review Published on 2021-11-232022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 치료제, [키워드] alkaloids antiviral medicine antiviral properties bioactive molecules biological significance Control coronavirus CoV COVID-19 COVID-19 outbreak CoVs death effective flavonoids globe hazard HCoV Health human coronavirus humans life cycles medication medications MERS natural pandemic positive-sense RNA virus positive-sense RNA viruses Prevent respiratory respiratory infectious disease resulting RNA genome SARS-CoV-2 spike terpenoids Treatment treatment of COVID-19 variety viruses [DOI] 10.3390/ijms222312638 PMC 바로가기 [Article Type] Review
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses고도로 병원성 코로나 바이러스를 포함하여 포집 바이러스에 대한 광범위한 항 바이러스 활성을 갖는 광 활성화 가능한 천연 제품Antiviral Agents Published on 2021-11-222022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] active against activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents broad-spectrum antiviral broad-spectrum antivirals bronchial epithelial cells Cell fusion coronavirus CoV replication CoV-229E COVID-19 COVID-19 therapy CoVs Cryoelectron microscopy demonstrated described Disinfection epithelial cells highly active human CoV Including inhibit inhibitor mechanism of action MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus natural natural antiviral natural product outbreak primary human bronchial epithelial cells product reduced Replication respiratory respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown therapy Viral viral membrane viral particle virucidal virus virus entry viruses [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 3CL activity acute respiratory syndrome Antiviral Antiviral effect antiviral efficacy Cell clade clinical trial coronavirus coronavirus 2 Coronaviruses CoV replication COVID-19 pandemic CoVs Curcuma direct-acting antiviral drug enzymatic activity function had no Helicase hepatitis C virus herbal medicine human coronavirus in vitro Infection inhibit inhibited inhibitory management mechanism noroviruses pan-coronavirus antivirals polymerase predominant protease reduced Replication respiratory RNA SARS-CoV-1 SARS-CoV-2 therapeutic option variants variants of concern Viral RNA while xanthorrhizol [DOI] 10.3390/biomedicines9111725 PMC 바로가기 [Article Type] Article
The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks천산갑에서 SARS-CoV-2 관련 코로나바이러스의 높은 다양성은 잠재적인 생태학적 위험을 경고합니다Article Published on 2021-11-182022-09-11 Journal: Zoological research [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Analysis anticipated Asia capture sequencing Chinese coronavirus CoVs Critical Customs Diversity DNA ecological English Evolution Genetic genetic diversity genome sequence Guangxi indicated individual mitochondrial mitochondrial DNA mtDNA muscle muscles Outbreaks pangolin pangolin-CoV pangolins pathogenic phylogenetic analyses phylogeographic analysis positive Recombination reservoir risk SARS-CoV-2 screened Sequencing solution Transmission understanding zoonotic zoonotic origin [DOI] 10.24272/j.issn.2095-8137.2021.334 PMC 바로가기 [Article Type] Article
Conserved molecular signatures in the spike protein provide evidence indicating the origin of SARS-CoV-2 and a Pangolin-CoV (MP789) by recombination(s) between specific lineages of SarbecovirusesBioinformatics Published on 2021-11-122022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] analyzed Bat CoVZXC21, CoVZC45, PrC31 clade Cluster components conserved Conserved signature indels (CSIs) Coronaviruses CoV CoVs CSI Deletion domain Evidence exhibit Genetic genetic recombination highest Host identify independent Interaction involved Lineage marker molecular Molecular signatures N-terminal domain NTD nucleocapsid protein Origin of SARS-CoV-2 virus pangolin CoV Pangolin CoV_MP789 Recombination recombination event reported Result S1-NTD sarbecovirus Sarbecoviruses SARS and SARS-CoV-2-related viruses SARS Coronavirus SARS-CoV-2 SARS-CoV-2 virus sequence sequence similarity similarity Spike protein Strains Support the SARS-CoV-2 the SARS-CoV-2 virus the spike protein virus viruses [DOI] 10.7717/peerj.12434 PMC 바로가기 [Article Type] Bioinformatics