Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients스파이크, 막 및 뉴클레오캡시드 SARS-CoV-2 단백질에 대한 강력한 T 세포 반응은 심각한 COVID-19 환자의 회복과 관련이 없습니다Article Published on 2020-09-222022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] Activation CD4 CD8 clearance comparable COVID-19 COVID-19 severity Critical critical COVID-19 critical COVID-19 patient critical COVID-19 patients critical patients Diagnosis dominance donors effector T cell Frequency highest Hyperreactivity Hypothesis Immunity Immunopathogenesis immunopathology indicate induce magnitude membrane memory moderate N protein nucleocapsid patients peptide peptide pool Protein Proteins response robust S/M/N protein-reactive T cells SARS-CoV-2 SARS-CoV-2 spike spike Support survival T cell T cell response T cell responses T cells vaccination virus clearance [DOI] 10.1016/j.xcrm.2020.100092 PMC 바로가기 [Article Type] Article
Risks and features of secondary infections in severe and critical ill COVID-19 patientsResearch Article Published on 2020-09-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] accompanied Admission Bacteria blood sample Characteristics clinical collected COVID-19 COVID-19 patient Critical critical COVID-19 patient critical COVID-19 patients Culture described diagnostic discharge rate feature fungi Infection infection rate infections intensive care intravascular devices intubation invasive Invasive mechanical ventilation laboratory data mortality rate objective pathogen Patient performed Prognosis proportion receiving respiratory respiratory infections respiratory ventilations Result risk SARS-CoV-2 Secondary infection secondary infections Sequencing severe COVID-19 Shanghai tracheal Urine Ventilation virus worsened [DOI] 10.1080/22221751.2020.1812437 PMC 바로가기 [Article Type] Research Article
Immune characteristics of severe and critical COVID-19 patientsLetter Published on 2020-08-312022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 바이오마커, [키워드] Characteristics critical COVID-19 patient Diseases Medical research [DOI] 10.1038/s41392-020-00296-3 PMC 바로가기 [Article Type] Letter
Type III interferons disrupt the lung epithelial barrier upon viral recognitionReport Published on 2020-08-072022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] aberrant immune response acute respiratory syndrome airway Antiviral antiviral immunity bacterial superinfections cause characterized Clinical practice contribute coronavirus coronavirus disease COVID-19 COVID-19 patient Critical critical COVID-19 patient dendritic cell disrupt driving elicit Endemic engage ENhance epithelial Evidence expressed expression functions IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs Immune cell immunopathology increase indicate induce Infection influenza infection Influenza virus inhibiting interfere ISGs Local Lower respiratory tract lung lung epithelial lung epithelium Major mice morbidity Mortality Mounting mucosal surface Necrosis p53 parameter Pathogenesis pathophysiological Patient Peripheral blood produced proinflammatory proliferation respiratory viral infections response responses RNA viruses SARS-CoV-2 Science secreted Severe case severity susceptibility therapeutic thought Transcription Trigger turn Type type I Type I IFN Type III IFN type III interferon viral burden viral infections viral respiratory disease viral respiratory infections Viral RNA viruses [DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patientsReport Published on 2020-08-072022-10-06 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA [DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report
Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseasesResearch article Published on 2020-07-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 치료법, [키워드] ACE2 adverse effects affected collected convalescent plasma country COVID COVID-19 COVID-19 patient critical COVID-19 patient diabete diabetes Elsevier Francis globe Google infected individual Infection liver Liver disease liver diseases liver dysfunction Nature Neutralizing antibodies Occurrence pandemic Patient plasma protocol randomised clinical trial recovered patient Result risk SARS-CoV-2 SARS-COV-2 infection specific treatment symptomatic Taylor therapy treat Treatment Treatment protocol underlying disease viral disease viral infection WHO guidelines [DOI] 10.1016/j.dsx.2020.05.023 [Article Type] Research article
Bedside rapid placement of nasointestinal feeding tube via ultrasound-guided stylet positioning in critical COVID-19 patientsResearch Letter Published on 2020-06-182022-11-01 Journal: Critical Care [Category] Coronavirus, SARS, [키워드] critical COVID-19 patient [DOI] 10.1186/s13054-020-02990-8 PMC 바로가기 [Article Type] Research Letter