Label-free electrochemical aptasensor for rapid detection of SARS-CoV-2 spike glycoprotein based on the composite of Cu(OH) 2 nanorods arrays as a high-performance surface substrate고성능 표면 기판으로서 Cu(OH) 2 나노로드 어레이의 합성물을 기반으로 한 SARS-CoV-2 스파이크 당단백질의 신속한 검출을 위한 무표지 전기화학 앱타센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료제, [키워드] addition aptamer Aptamer-based sensors carbon Chain Reaction characterized Combination complexes copper Copper hydroxide nanorods COVID-19 cross-reactivity decrease Detection limit diffraction dynamic range Efficiency electrode electron microscopy electron transfer evaluated exhibited feasibility glycoprotein healthy individual high stability hydroxide immobilization lAbel Microscopy PCR polymerase chain polymerase chain reaction probe provided repeatability reproducibility Saliva SARS-CoV-2 SARS-CoV-2 spike glycoprotein Screen sensitivity sick spike spike glycoprotein transport medium Viral transport medium VTM was used X-ray X-ray diffraction [DOI] 10.1016/j.bioelechem.2022.108106 PMC 바로가기 [Article Type] Article
CRISPR-Cas12a-mediated label-free electrochemical aptamer-based sensor for SARS-CoV-2 antigen detectionSARS-CoV-2 항원 검출을 위한 CRISPR-Cas12a 매개 무표지 전기화학 앱타머 기반 센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료법, [키워드] amplification Antigen aptamer Biomarkers cleavage competitive binding complex COVID-19 CRISPR CRISPR-Cas12a cross-reactivity diagnostic DNA electrochemical biosensor expand generate gold impedance in vitro nucleocapsid antigen Quantitative resulting Rolling circle amplification SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 nucleocapsid selective significant decrease significantly [DOI] 10.1016/j.bioelechem.2022.108105 PMC 바로가기 [Article Type] Article
Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assayarticle Published on 2022-07-312024-09-01 Journal: eLife [Category] 말라리아, [키워드] antibody cross-reactivity FluoroSpot immunology Infectious disease Inflammation Microbiology P. falciparum [Article Type] article
Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs신흥 SARS-CoV-2 VOC의 Ad5 벡터 스파이크 단백질에 의해 유도된 항체 반응의 비교 특성화Comparative Study Published on 2022-07-292022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration Alpha analyzed antibody Antibody Response Antibody responses B.1.351 B.1.429 B.1.617.2 Beta booster Characteristics Comparative cross-neutralizing antibody cross-reactivity Delta Effects elicit elicited Epsilon Gamma Heterologous immune response immune responses Lineage mice Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses omicron other variant other variants pandemic produced provided regimens responses against SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Single-dose spike Spike protein Spike proteins Spread stimulate the SARS-CoV-2 the vaccine unique vaccination Vaccination strategy Vaccine Vaccine development variants VoC VOCs [DOI] 10.1038/s41392-022-01065-0 PMC 바로가기 [Article Type] Comparative Study
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent IndividualsSARS-CoV-2 스파이크의 Omicron BA.1 돌연변이는 백신 접종 및 회복기 개인의 T-세포 반응 감소로 이어집니다Article Published on 2022-07-192022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alleles BNT162b2 BNT162b2 vaccine CD4 CD4+ T-cell CD4+ T-cell epitopes cellular immunity circulating cross-reactive cross-reactivity elicited Epitopes escape facilitated help HLA HLA class II HLA class II alleles HLA motif prediction immune Immune escape immunodominant epitope immunodominant epitopes individual infect loss of memory memory monitoring motif mRNA mRNA-based Mutation mutations natural infection Neutralizing antibodies omicron Omicron BA.1 variant predict predicted preserved reactivity response SARS-CoV-2 SARS-CoV-2 immunity selected spike Spike protein spike-protein strain T cell T cells T-cell T-cell epitope T-cell epitopes T-cell Response T-cell responses the spike protein vaccination variant virus variant virus variants [DOI] 10.3390/v14071570 PMC 바로가기 [Article Type] Article
Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant어린이의 조상 SARS-CoV-2에 대한 특정 CD4+ T 세포 반응은 나이가 들어감에 따라 증가하고 베타 변이체에 대한 교차 반응성을 나타냅니다Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accompanied Activation activation induced marker (AIM) activation-induced marker activation-induced markers age ancestral Antiviral average Beta Beta variant beta variants Blood CD4+ CD4+ T cell children Control convalescent coronavirus COVID-19 cross-reactivity Cytokines cytometric disease course Effective vaccines Flow global health granzyme granzyme B HCoV Health human coronavirus human coronavirus (HCoV) IFN-γ immune response increase Infection infection rate infection rates marker Mild mononuclear cell PBMC pediatric peptide peripheral Peripheral blood Peripheral blood mononuclear cells reduced reduction response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant secreted cytokine secretion seronegative show social distancing measures Specific stimulated T cell T cell responses T cells the SARS-CoV-2 vaccination variant variant of concern (VOC) viral variant VoC was reduced were used [DOI] 10.3389/fimmu.2022.867577 PMC 바로가기 [Article Type] Article
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article
Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응Article Published on 2022-07-122022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] alphacoronavirus antibody Antibody binding association Betacoronavirus boosting cause Cohort coronavirus COVID-19 cross-react cross-reactive cross-reactive antibody cross-reactivity Endemic endemic human coronavirus Evidence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic IgG IgG antibody titer Infant Infants Kenya lack levels of antibody memory response mother mothers. response risk SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection Seroconversion unlikely women [DOI] 10.3390/v14071517 PMC 바로가기 [Article Type] Article