CRS – Page 6 – Communicable Diseases Research

Are all cytokine storms the same?

모든 사이토카인 폭풍은 동일합니까?

Article

Published on 2021-04-012022-09-11
Journal: Cancer immunology, immunotherapy : CII [Category] SARS, 바이오마커,

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

COVID-19 발병의 전염증성 사이토카인: 무엇이 잘못되었습니까?

Review

Published on 2021-04-012022-09-12
Journal: Microbial pathogenesis [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] addition appear cause caused China Clinical outcome contribute coronavirus 2 coronavirus disease country COVID-19 CRS cytokine Cytokine release syndrome Cytokines described effector cell exacerbated extensive lung damage human SARS-CoV-2 IL-17 IL-1β IL-6 IL-8 immune immune response immune system immunological infected with SARS-CoV-2 Infection Inflammation involved knowledge MERS non-immune outbreak Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines pulmonary inflammation respiratory SARS-CoV-2 Severe case severe COVID-19 patients spread to subject systemic inflammatory response thrombosis TNFα
[DOI] 10.1016/j.micpath.2021.104799 PMC 바로가기 [Article Type] Review

Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients

Article

Published on 2021-03-152022-10-04
Journal: Cell Death Discovery [Category] 임상, 치료제,

[키워드] acute respiratory distress administration of corticosteroid Admission Alveolar macrophages ARDS association average BALF Care Cell cell type clinical trial Corticosteroid corticosteroid therapy COVID-19 patient COVID-19 severity Critically ill CRS Cytokine release syndrome death Dexamethasone driven by Drug development Endothelial cell Examining glucocorticoid ICU IL-6 IL-6 expression IL-6 level IL-6 levels Interim Mortality NR3C1 outcome oxygen Patient plasma Predictive markers receive receptor Regulation severe COVID-19 patient single-cell RNA-seq smooth muscle cells survival syndrome Ventilation viral infection
[DOI] 10.1038/s41420-021-00429-9 PMC 바로가기 [Article Type] Article

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Article

Published on 2021-03-122022-10-04
Journal: Nature Communications [Category] SARS, 바이오마커, 치료기술, 치료법,

[키워드] Affect alteration arginine association change chemokine Correlation analysis COVID-19 COVID-19 patient COVID-19 patients CRS cytokine cytokine release Cytokines Diseases Ex vivo healthy controls Host hyperinflammation IL-1α IL-1β IL-6 immune response implication Inflammatory response Injury M-CSF metabolic pathway metabolism metabolite metabolite analysis metabolomic metabolomics Mild modulate mononuclear cell outcome Peripheral blood Prognostic markers proinflammatory Proinflammatory cytokine purine Regulatory reveal rhesus macaque SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 patients stratified syndrome therapeutic therapeutic target
[DOI] 10.1038/s41467-021-21907-9 PMC 바로가기 [Article Type] Article

Multimodality treatment in immunocompromised patients with severe COVID ‐19: the role of IL ‐6 inhibitor, intravenous immunoglobulin, and haemoperfusion

Case Report

Published on 2021-03-072022-10-29
Journal: Respirology Case Reports [Category] COVID-19,

Late onset infectious complications and safety of tocilizumab in the management of COVID-19

COVID-19 관리에서 늦은 발병 감염성 합병증 및 토실리주맙의 안전성

Article

Published on 2021-03-012022-09-11
Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 진단, 치료제,

[키워드] 48 hours Admission Allergic reactions Bacterial chemokine clinical trial Complication concern control group coronavirus COVID-19 COVID-19 patients CRS cytokine Cytokine release syndrome cytokine/chemokine diverticulitis Efficacy elevated Elevation evaluate evaluated greater hypertension IL-6 IL-6 inhibition immune immune responses incidence Infection infectious complication infusion Inpatient intensive care intensive care unit admission Liver function test liver function tests management mechanical ventilation mortality rate MOST neutropenia occurred Patient Pneumonia Reactions receiving risk of infection SARS Coronavirus significantly more TCZ Tocilizumab toxicities Toxicity weighed while with COVID-19
[DOI] 10.1002/jmv.26429 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Causes a Different Cytokine Response Compared to Other Cytokine Storm-Causing Respiratory Viruses in Severely Ill Patients

Immunology

Published on 2021-03-012022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] activate adaptive alleviate analyzed cause caused collected conserved contributing to coronavirus Coronavirus 2019 COVID-19 COVID-19 cases CRS cytokine cytokine level Cytokine release syndrome cytokine response Cytokine storm different disease downstream dysregulation evaluate exacerbated Factor H5N1 H7N9 help highlight identify IFN IL-10 IL-2 IL-4 IL-5 Ill Immune cell indicate induce Infection Inflammation Influenza influenza A interferon Intervention literature analysis MERS- and SARS-CoV MERS-CoV Mortality occur Other other coronavirus outbreak Patient patient data prevalent pro-inflammatory cytokines producing respiratory respiratory viruses response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic subgroup of patients systematic review the SARS-CoV-2 unique viral pathogen virus viruses
[DOI] 10.3389/fimmu.2021.629193 PMC 바로가기 [Article Type] Immunology

The COVID-19 Treatment Landscape: A South African Perspective on a Race Against Time

Medicine

Published on 2021-02-192022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] “cytokine storm” acute respiratory distress affected African Against Antimalarials antivirals ARDS benefit cause caused changed clinical benefit clinical trials COVID-19 CRS Cytokine release syndrome Dexamethasone disease dosage drug Effect greater greatest number healthcare HFNC High flow nasal oxygen high mortality rate identify implementation invasive ventilation Local multi-organ dysfunction nasal NIV non-invasive ventilation oxygen pandemic Patient patients race randomized trial receiving reflect report required resource SARS-CoV-2 shown South South Africa standardized protocols syndrome Thrombotic complications time tissue damage Tocilizumab Treatment treatment strategy Trial virus
[DOI] 10.3389/fmed.2021.604087 PMC 바로가기 [Article Type] Medicine

Anti-BCMA CAR T administration in a relapsed and refractory multiple myeloma patient after COVID-19 infection: a case report

COVID-19 감염 후 재발 및 불응성 다발성 골수종 환자에서 항BCMA CAR T 투여: 증례 보고

Case Reports

Published on 2021-02-192022-09-12
Journal: Journal of Medical Case Reports [Category] MERS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Antigen antigen receptor antiviral antibodies antiviral antibody benefit Cancer patients CAR CAR T cell Case report Cell Cell therapy Chemotherapy chimeric antigen receptor clinical recovery clinical study Complete coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19-related complications criteria CRS Cytokine release syndrome decision detectable dose Enrollment exacerbate global pandemic group Host immune immune response Immunosuppression infections initial male maturation Multiple myeloma Myeloma novel Novel coronavirus novel coronavirus disease pandemic Patient potential risk proceed receiving Registered risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus susceptible T cell the patient the SARS-CoV-2 virus therapy treated Treatment viral infection working
[DOI] 10.1186/s13256-020-02598-0 PMC 바로가기 [Article Type] Case Reports

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

COVID-19 관련 사이토카인 폭풍 증후군 및 진단 원칙: 오래된 문제와 새로운 문제

Review

Published on 2021-02-182022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen Autoimmune disease Autoimmune diseases autologous benefit Bone marrow CAR-T Characteristics chimeric chimeric antigen receptor claimed clinical experience Clinical sign Clinical signs clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRS CSS cytokine cytokine release Cytokine release syndrome Cytokine storm Cytokine storm syndrome Cytokines Deterioration diagnosed diagnoses diagnosing Diagnosis diagnostic Diagnostic Criteria disease early stage early stages Evolution familial/primary hemophagocytic lymphohistiocytosis hemophagocyte hemophagocytic lymphohistiocytosis hemophagocytic syndrome HLH include issue less limitation Macrophage macrophage activation macrophage activation syndrome malignancy mechanisms non-specific paper Pathogenesis Patient Research respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis sensitivity severe acute respiratory syndrome Coronavirus sHLH Signs and symptoms Symptoms T-cell T-cell receptor therapy
[DOI] 10.1080/22221751.2021.1884503 PMC 바로가기 [Article Type] Review