Defense – Page 6 – Communicable Diseases Research

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation

Z-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할

Review

Published on 2022-06-282022-09-11
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘,

The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b

Deubiquitinase USP29는 ORF9b의 프로테아좀 분해를 방지하여 SARS-CoV-2 독성을 촉진합니다

Article

Published on 2022-06-282022-09-11
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antiviral biological processes canonical carboxyl caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense Degradation deubiquitinase deubiquitination. develop E3 ubiquitin ligase E3 ubiquitin ligases effort eGFP enhancement Evidence Health healthy help Host host defense hosts IFN IFN-I IKKɑ Immunity inhibit inhibiting innate immune response Intensive interact Interaction IκB mechanisms Modification mRNA level NF-κB NF-κB activation Orf9b Particles pathogen pathogenicity pathway Prevent Preventing proliferation proteasomal proteasome Protein regulate Regulation Replication replication-competent SARS-CoV-2 restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Signaling subsequent Transcription Type I IFN type I interferon ubiquitin USP29 viral infections virulence
[DOI] 10.1128/mbio.01300-22 PMC 바로가기 [Article Type] Article

Assessment of the frequency of coughing and sneezing triggered by nasopharyngeal swabbing in the pandemic setting

Observational Study

Published on 2022-06-272022-10-04
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상,

[키워드] aerosol Aerosols age assessment chi-square test Consensus Contact Contamination coughing Defense develop evaluated event Frequency generate individual individuals Infection limit mucosa Nasopharyngeal swab nasopharyngeal swabbing no significant difference Observational cohort study Occurrence pandemic participant Particles persistence Personal protective equipment positive PPE Prevalence Prospective reported risk RT-PCR SARS-CoV-2 SARS-CoV-2 positive individuals Sex significant difference specimen Spread tested Testing the SARS-CoV-2 Trigger triggered variety Ventilation Viral load
[DOI] 10.1038/s41598-022-14755-0 PMC 바로가기 [Article Type] Observational Study

Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법

Review

Published on 2022-06-252022-09-11
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘,

[키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread
[DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review

Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19

코로나바이러스 감염과 인터페론 반응: 바이러스 숙주 군비 경쟁과 COVID-19

Review

Published on 2022-06-212022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug Arm caused cellular clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 patient Defense Early detection effective functional host cell host cells Hypothesis innate immune interact Interaction interferon Mild morbidity morbidity and mortality no symptoms pandemic Pathogenesis pathway Pattern recognition pattern recognition receptor Pattern recognition receptors pattern-recognition receptor. PRR PRRs race receptor reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins secretion severe acute respiratory syndrome Coronavirus severe COVID-19 shown signaling pathway suffered susceptibility Variability virus
[DOI] 10.3390/v14071349 PMC 바로가기 [Article Type] Review

Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19

매우 심각하거나 치명적인 COVID-19가 있는 65세 미만의 피험자에서 드문 잠재적 병원성 변이의 존재

Article

Published on 2022-06-202022-09-11
Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘,

Athletes’ Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients

운동선수의 중간엽 줄기세포는 오마이크론에 감염된 환자의 세포 치료를 위한 최선의 선택이 될 수 있습니다

Article

Published on 2022-06-142022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar anti-apoptotic Anti-inflammatory antioxidant athlete Breakthrough infection breakthrough infections caused Cell cell survival choice coronavirus COVID-19 Cytokines Defense defense mechanisms effective epithelial cells exercise growth growth rate growth signaling highlight immunomodulatory incidence Inflammation Ischemia mechanism microenvironment Mutation New omicron outcome oxidative stress patients Re-infections reduce reduced respiratory epithelial cell respiratory epithelial cells SARS-CoV-2 secretion sport STEM stem cell stem cells stem-cell therapy suggested Support survival therapy transplantation Treatment Vaccine variant variants
[DOI] 10.3390/cells11121926 PMC 바로가기 [Article Type] Article

A short review on RT-PCR and graphene-based materials in COVID detection

Research article

Published on 2022-06-072022-10-05
Journal: Sensors (Basel, Switzerland) [Category] 치료기술,

[키워드] biosensors Care carried Chemistry country COVID COVID-19 Defense exhibiting global pandemic Graphene Graphene mask Health health worker pandemic Pharmacy Research researchers RT-PCR Support Vaccine
[DOI] 10.1016/j.matpr.2022.05.347 [Article Type] Research article

Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3

임상 데이터 마이닝은 IL-6/STAT3에 대한 이중 결합에 의해 중간 정도의 CovID-19에 대한 잠재적 인 허브 쌍으로 간카오-밴 내증을 밝혀냅니다.

Article

Published on 2022-06-012022-08-31
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료제,

[키워드] activator Analysis applied association benzyl binding Bioinformatic Chinese Chinese medicines (CMs) clinical clinical records Commission coniferin coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokine storm Data mining Defense demonstrated dual FIVE Frequency Gancao-Banxia Gene ontology genomes group highest IL-6 immune response immune responses indicated Inflammatory response ingredient inhibit interleukin interleukin-6 Interleukin-6 (IL-6) KEGG Kyoto licochalcone a Medicine Moderate COVID-19 moderate COVID-19 patients molecular docking multisite network network pharmacology Pathways patients piperazine potential mechanisms PPI protein-protein interaction provided quercetin quinone Radix reveal SARS-CoV-2 signal Signal transducer and activator of transcription Signal transducer and activator of transcription 3 (STAT3). signaling pathways STAT3 Support target targets the cytokine storm therapeutic efficacy therapy Transcription Viral were used
[DOI] 10.1016/j.compbiomed.2022.105457 PMC 바로가기 [Article Type] Article

Influence of exercise and vitamin D on the immune system against Covid-19: an integrative review of current literature

Covid-19에 대한 면역 체계에 대한 운동과 비타민 D의 영향: 현재 문헌의 통합 검토

Review

Published on 2022-06-012022-09-11
Journal: Molecular and cellular biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome coronavirus addition affected age anti-inflammatory cytokine anti-inflammatory cytokines association caused chronic disease Chronic diseases Concentration contribute coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines Defense defense mechanism environmental factors Factor genetics Health Organization health system Hypovitaminosis D IL-10 IL-1β IL-4 IL-6 immune response immune system increase in Infection infections Infectious disease Infectious diseases influence maintenance mechanism microorganisms morbidity morbidity and mortality New coronavirus nutritional status pandemic Patient physical physical activity Physical exercise Physical status pro-inflammatory cytokine pro-inflammatory cytokines reduction in Regular respiratory respiratory infections responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly the cytokine storm the disease therapy TNF-α triggering viral infections virus Vitamin D vitamin D level vitamin D levels WHO World Health Organization
[DOI] 10.1007/s11010-022-04402-7 PMC 바로가기 [Article Type] Review