degrade – Page 6 – Communicable Diseases Research

Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense

Discoveries

Published on 2020-09-142022-10-29
Journal: Molecular Biology and Evolution [Category] COVID-19, SARS,

Effect of COVID-19 Precautions on Neonatal Resuscitation Practice: A Balance Between Healthcare Provider Safety, Infection Control, and Effective Neonatal Care

Pediatrics

Published on 2020-08-182022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

Short Report

Published on 2020-07-072022-10-31
Journal: eLife [Category] COVID-19, SARS,

[키워드] ACE ACE2 activate addition addressed Affect affected affecting Analysis analyzed Atypical BALF blood pressure blood vessel bradykinin Brain Bronchoalveolar lavage fluid cause caused Cell changes in China clinical trial clinician collected Combination contribute Control cough COVID-19 COVID-19 patient COVID-19 patients Critical decrease decreased expression degrade develop disease drug effective enzyme expand experiment explain Gene Expression help high temperature Host Human Hyaluronic acid identify increases in individual induce Inflammation life-threatening Lower lung lung cell maintain mechanism Mild molecular mechanism multiple tissue new virus no symptom opposite outcome oxygen uptake Pain Pathogenesis Patient patients with COVID-19 predicted previous study produced provide RAS receptors regulate renin-angiotensin system researcher responsible risk SARS-CoV-2 sequence severe symptom shown Spread storm Symptom Symptoms symptoms of COVID-19 the disease the SARS-CoV-2 virus therapeutic intervention tissue treat treatments for COVID-19 turn vascular dilation vascular permeability virus was increased were used
[DOI] 10.7554/eLife.59177 PMC 바로가기 [Article Type] Short Report

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Viewpoint

Published on 2020-06-192022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

Towards reduction in bias in epidemic curves due to outcome misclassification through Bayesian analysis of time-series of laboratory test results: case study of COVID-19 in Alberta, Canada and Philadelphia, USA

Research Article

Published on 2020-06-062022-10-28
Journal: BMC Medical Research Methodology [Category] COVID-19, Fulltext, SARS,

Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3

Article

Published on 2020-05-312022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase L

Research Article

Published on 2018-04-132022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

A genetic switch controls the production of flagella and toxins in Clostridium difficile

유전자 스위치는 Clostridium difficile의 편모 및 독소 생성을 제어합니다

Research Article

Published on 2017-03-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate addition antibiotic Bacteria Bacterial Bacterial infection bacterial pathogen cause characterization Clostridium difficile colonization Control Coordinate Course degrade described determinant determine detrimental effect diarrheal diarrheal disease disease early stage Effect engage enzyme epithelial cells Evidence expressed expression Factor flagella flagellar flagellar gene flagellum Gene Expression Gene regulation Genes Genetic growth Host host tissue Impact in vitro inactivation independent independent of Infection intestinal intestinal epithelial cells intestine inversion isolates mechanism motility mRNA Mutagenesis occur Orientation pathogen phase produced promote regulate Regulation regulator Regulatory responsible secrete secreted secretion sequence severity SigD Structure toxin toxins tyrosine upstream virulence virulence factors
[DOI] 10.1371/journal.pgen.1006701 PMC 바로가기 [Article Type] Research Article

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia

HIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할

Research Article

Published on 2016-03-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load
[DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article