X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia
X-연관 TLR7 결핍은 운동실조-모세혈관확장증 남성 환자의 심각한 COVID-19 폐렴의 원인이 됩니다
Case Reports
[키워드] antibody
Antibody deficiency
Asymptomatic
Ataxia
ataxia-telangiectasia
ATM
autoantibodies
autoantibody
candidate gene
clinical manifestations
conditions
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 immune response
COVID-19 pneumonia
Critical
critical COVID-19
deficiencies
deficiency
Deleterious
Diagnosis
disease
evaluated
exhibit
Exome
genetic cause
genetic defect
genetic defects
high risk
homozygous
identify
IFNs
IgM
immune response
Immunity
Impact
inborn errors of immunity
individual
interferons
investigated
life-threatening
mechanism
Mild symptom
mild symptoms
Mutation
neurological signs
objective
Patient
patients evaluated
Pneumonia
Primary Immunodeficiency
radiosensitivity
Result
SARS-COV-2 infection
Sequencing
serum levels
specific antibodies
specific antibody
supplementary material
syndrome
telangiectasia
the patient
TLR7
TLR7 gene
Treatment
Type I IFN
type I interferon
type I interferons
underlie
understanding
unique
variant
virus
was performed
were measured
[DOI] 10.1007/s10875-021-01151-y PMC 바로가기 [Article Type] Case Reports
[DOI] 10.1007/s10875-021-01151-y PMC 바로가기 [Article Type] Case Reports