Identifying Effective Antiviral Drugs Against SARS-CoV-2 by Drug Repositioning Through Virus-Drug Association Prediction바이러스-약물 연관성 예측을 통한 약물 재배치로 SARS-CoV-2에 대한 효과적인 항바이러스 약물 식별Genetics Published on 2020-09-162022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 addition Against angiotensin antiviral drug antiviral drugs association AUC best binding energy bipartite bipartite local model chemical structures Chloroquine Classifier clinical trial clinical trials Complete coronavirus death drug drug repositioning drugs effective antiviral treatment FIVE FK506 followed by genome sequence human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 identify identifying infected case information Local molecular mycophenolic acid neighbor association information New coronavirus over predicted prediction Prevent regularized least square Remdesivir reported repositioning ribavirin RLS SARS-CoV-2 Spike protein Structure suggested supported the spike protein VDA VDA identification model VDA-RLSBN VDAs virus virus-drug association viruses [DOI] 10.3389/fgene.2020.577387 PMC 바로가기 [Article Type] Genetics
Application of Artificial Intelligence in COVID-19 drug repurposingReview article Published on 2020-09-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 신약개발, 치료제, [키워드] active against analyzed application applied approach artificial artificial intelligence coronavirus COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients deep learning detect drug Drug discovery drug repositioning Drug repurposing drugs Efficiency emerging disease feasible Google Scholar IMPROVE intelligence machine learning outcome pandemic Patient patients reported Result SARS-CoV-2 shown significantly the disease therapeutic treat Treatment Virtual screening [DOI] 10.1016/j.dsx.2020.06.068 [Article Type] Review article
Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infectionArticle Published on 2020-08-162023-06-16 Journal: Expert review of anti-infective therapy [Category] MERS, [키워드] COVID-19 drug repositioning Hydroxychloroquine Post-exposure prophylaxis pre-exposure prophylaxis Prophylaxis Remdesivir SARS-CoV-2 Treatment Vitamin D [DOI] 10.1080/14787210.2020.1799785 PMC 바로가기
Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2Perspective Published on 2020-07-232023-06-14 Journal: Biochemical pharmacology [Category] MERS, SARS, [키워드] 2019-nCoV, 2019 novel coronavirus 3CLpro, chymotrypsin‐like protease AAK1, AP2-associated kinase 1 ACE2, angiotensin-converting enzyme 2 ADE, antibody-dependent enhancement, ALI, acute lung injury Antiviral agents ARDS, acute respiratory distress syndrome CAR, chimeric antigen receptors CAS, Chemical Abstracts Service coronavirus CoV, coronavirus COVID-19 COVID-19, Corona virus disease 2019 CT, Computed tomography Cytokine storm DAMPs, danger-associated molecular patterns drug repositioning E, Envelope ERGIC, endoplasmic reticulum-Golgi apparatus intermediate compartment G-CSF, granulocyte-colony stimulating factor GAK, cyclin G–associated kinase HBV, hepatitis B virus HCV, hepatitis C virus HScore, hemophagocytosis score ICU, Intensive care unit IL, interleukin IP-10, interferon-γ-inducible protein 10 IRF3, interferon regulatory factor 3 JAK, Janus kinases LMWH, low molecular weight heparin M, membrane Mpro, main protease mAb, monoclonal antibody MCP, monocyte chemoattractant protein MERS-CoV, Middle East respiratory syndrome coronavirus MIP1α, macrophage inflammatory protein MRSA, methicillin-resistant Staphylococcus aureus MSCs, mesenchymal stem cells N, nucleocapsid NF-kB, nuclear factor-kB NSPs, Nonstructural proteins ORF, open reading frames PDE-5, phosphodiesterase-5 PLpro, papain‐like protease PRRs, Pattern Recognition Receptors RBD, receptor-binding domain S, spike S1P, sphingosine 1-phosphate SARS-CoV-2 SARS, Severe acute respiratory syndrome sHLH, secondary hemophagocytic lymphohistiocytosis STAT, Signal transducer and activator of transcription TLR, Toll-like receptor TMPRSS2, transmembrane protease serine 2 protease TNFα, tumor necrosis factor α tPa, tissue-type plasminogen activator UFH, unfractionated heparin VEGF-A, vascular endothelial growth factor-A VIP, vasoactive intestinal polypeptide [DOI] 10.1016/j.bcp.2020.114169 PMC 바로가기 [Article Type] Perspective
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax컴퓨터 화학유전체학 약물 재배치 전략이 플라스모디움 팔시파룸과 P. 비박스에 대한 새로운 재배치 히트로 에피루비신의 발견을 가능하게 한다.Article Published on 2020-06-292024-08-11 Journal: Med Instrum [Category] 말라리아, [키워드] chemogenomics DNA gyrase drug repositioning epirubicin malaria [DOI] 10.1128/AAC.02041-19 PMC 바로가기
Drug Repurposing for COVID-19: Ethical Considerations and RoadmapsCOVID-19에 대한 약물 용도 변경: 윤리적 고려 사항 및 로드맵Research Article Published on 2020-06-052022-08-31 Journal: Cambridge Quarterly of Healthcare Ethics [Category] SARS, 신약개발, [키워드] addressed Clinical research COVID-19 develop distribution drug drug repositioning Drug repurposing emergency situation Evidence integrity issue Japanese obtaining information patients Perspective repurposing required Research Research Ethics resource resource distribution treatments for COVID-19 while [DOI] 10.1017/S0963180120000481 PMC 바로가기 [Article Type] Research Article
Diacerein: A potential multi-target therapeutic drug for COVID-19Article Published on 2020-06-012023-07-01 Journal: Medical Hypotheses [Category] SARS, [키워드] COVID-19 treatment Diacerein drug repositioning rhein [DOI] 10.1016/j.mehy.2020.109920 PMC 바로가기 [Article Type] Article
Potential anti‐SARS‐CoV‐2 drug candidates identified through virtual screening of the ChEMBL database for compounds that target the main coronavirus proteaseResearch Article Published on 2020-05-292022-10-31 Journal: FEBS Open Bio [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus acute respiratory syndrome approved binding affinity ChEMBL clinical development Compound compounds coronavirus coronavirus disease COVID‐19 COVID‐19 Cys145 database described docking drug drug candidate drug candidates drug library drug repositioning drugs effective homodimer inhibitors M pro MPro Novel coronavirus pathogen PDB performed Potential predict predicted protease SARS‐CoV‐2 SARS‐CoV‐2 screenings significantly suggested Treatment Virtual screening was performed [DOI] 10.1002/2211-5463.12875 PMC 바로가기 [Article Type] Research Article
Delivering Benefits at Speed Through Real-World Repurposing of Off-Patent Drugs: The COVID-19 Pandemic as a Case in PointViewpoint Published on 2020-05-132022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, SARS, [키워드] clinical coronavirus disease country Course COVID-19 crisis drug drug candidates drug costs drug repositioning drugs drugs, generic Efficacy example facilitate Health Health care system Intervention off-label off-label use pandemic pathophysiology patients patients with COVID-19 physician Point public health Repository repurposing Safe severe acute respiratory syndrome coronavirus 2 speed Support supported Treatment Trial [DOI] 10.2196/19199 PMC 바로가기 [Article Type] Viewpoint
COVID-19 Drug Discovery Using Intensive ApproachesReview Published on 2020-04-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral therapy caused China clinical development clinical trial coronavirus coronavirus disease Coronaviruses COVID-19 drug Drug discovery drug repositioning Infection Infectious disease information inhibit mechanism MERS Middle East Pandemics provide reported response RNA RNA virus SARS-CoV-2 severe COVID-19 Spread standard treatment strain Symptoms syndrome therapeutic agent unique Vaccine viral replication while WHO World Health Organization [DOI] 10.3390/ijms21082839 PMC 바로가기 [Article Type] Review