To be or not to be vaccinated: The risk of MS or NMOSD relapse after COVID-19 vaccination and infectionObservational Study Published on 2022-09-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] 바이오마커, 임상, [키워드] Acute relapse age BNT162b2 Central nervous system COVID-19 COVID-19 infection COVID-19 vaccination demyelinating disorder determine disease disorder eight evaluate group immune-mediated diseases incidence increase in Infection interval Lower Mild morbidity and mortality Multiple multiple sclerosis Neuromyelitis Neuromyelitis Optica Observational cohort study Patient post-COVID-19 patient proportion retrospective risk risk factor Risk factors vaccination was collected [DOI] 10.1016/j.msard.2022.104014 PMC 바로가기 [Article Type] Observational Study
COVID-19-associated Mucormycosis: A clinico-epidemiological studyObservational Study Published on 2022-09-012022-10-05 Journal: Journal of diabetes and its complications [Category] SARS, 임상, [키워드] Admission age alkaline phosphatase Antibiotics Antifungal treatment Blood Group Chronic kidney disease COVID-19 COVID-19 illness death diabetes diagnosed disease eight enrolled epidemiological expected Follow-up Frequency hyperglycemia increase in India Ivermectin Mortality much lower Mucormycosis occurred Oxygen therapy pandemic Patient patients died Pneumonia Posaconazole positive raised required risk factor RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR serology serum creatinine significantly steroid Steroids survived the patient Treatment uncontrolled use of antibiotics ventilator was done Zinc zinc supplementation [DOI] 10.1016/j.jdiacomp.2022.108284 PMC 바로가기 [Article Type] Observational Study
Evaluation of the tolerability of monoclonal antibody therapy for pregnant patients with COVID-19Article Published on 2022-09-012022-11-15 Journal: The journal of obstetrics and gynaecology research [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration adverse event Blood Body body temperature Complication control group controls COVID-19 disease eight Epidemic evaluate Fever gestational age Hospitalization initial symptoms Japan Maternal Mild moderate monoclonal monoclonal antibody Neonatal Neonates outcome Patient Pregnancy pregnant patient pregnant women receive reduced required Safe Seven severity significantly significantly higher temperature therapy Tolerability treatment initiation variant were recorded were used with COVID-19 [DOI] 10.1111/jog.15338 PMC 바로가기
Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessmentSARS-CoV-2에 대한 항 HIV 약물 및 식물성 플라보노이드 조합: 분자 도킹 시뮬레이션 기반 평가Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] acute respiratory syndrome Analysis anti-HIV drug anti-HIV drugs Anti-inflammatory antimalarial drug Antimalarial drugs Antiviral clinical evidence Combination combination therapy combined effect complex coronavirus darunavir docking docking score drug drug-likeness eight enzyme flavonoid genome replication H-bond Health Hypothesis in viral individual Ligand ligands M pro MM/PBSA molecular molecular docking Molecular docking study molecular docking-simulation Patient phyto-flavonoid prophylactic therapy protease Protease inhibitor quercetin respiratory RMSF SARS-CoV-2 selected selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stability viral genome replication [DOI] 10.1080/07391102.2021.1885495 PMC 바로가기 [Article Type] Article
An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 임상, [키워드] 1:1 adverse event Analysis Anxiety approach approaches assigned Block randomisation breathlessness chronic obstructive clinically clinics complementary computer-generated conducted COVID COVID-19 eight element English Generalised anxiety disorder groups Health Imperial College London IMPROVE improvement individual intention-to-treat population Intervention Mental mental health MHC outcome measure parallel-group participant participated Patient physical potential participant Primary outcome pulmonary disease qualitative data randomisation randomised controlled trial Randomly recovering from COVID-19 recruited Registered reported Research researcher responses responsible secondary secondary outcome single-blind statistically significant Symptom thematic analysis treatment group Trial unique usual care usual care group Visual Analogue Scale was done were excluded were given [DOI] 10.1016/S2213-2600(22)00125-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Production of novel SARS-CoV-2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodiesArticle Published on 2022-09-012022-11-15 Journal: Biotechnology Journal [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Antibody binding antibody binding. binding Cell cells Chinese hamster Chinese hamster ovary cells COVID-19 develop diagnostics domain eight elicit evaluated Express expressed expression full-length IMPROVE Infection Modification monoclonal antibody outperform platform polyclonal Production Protein purified pursuit raised RBD Research responses SARS-CoV-2 sensitivity serological assays significantly spike the Spike vaccination viral entry [DOI] 10.1002/biot.202100678 PMC 바로가기
Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial말라위에서 9개월에서 12세 사이의 어린이를 대상으로 한 장티푸스 접합 백신의 안전성 및 면역원성: 이중 맹검, 무작위 대조 시험의 중첩 하위 연구Clinical Trial Published on 2022-09-012022-09-12 Journal: The Lancet. Global health [Category] Fulltext, MERS, 살모넬라증, 임상, 진단, [키워드] 1:1 95% CI adverse event age analysed antibody assigned baseline children chronic health conditions clinical trial COVID-19 double-blind eight eligible eligible participant ELISA enrolled evaluated Evidence foundation geometric mean titre HIV IgG Immunosuppression intention-to-treat population intramuscularly Local Melinda Gate occurred outcomes participant Phase 3 provide public health randomised controlled trial Randomly reactogenicity receive recipient recipients Registered remained Safety screened titre Tolerability Trial typhoid fever vaccination Vaccine was collected [DOI] 10.1016/S2214-109X(22)00275-3 PMC 바로가기 [Article Type] Clinical Trial
Immunogenicity and reactogenicity of an inactivated SARS-CoV-2 vaccine (BBV152) in children aged 2-18 years: interim data from an open-label, non-randomised, age de-escalation phase 2/3 studyClinical Trial Published on 2022-09-012022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% CI Administered Adults adverse event age all age group antibody baseline Bharat Biodefense children clinical conducted COVID-19 vaccine curtail deaths decrease demonstrated dose Efficacy eight eligible Endpoint enrolled female Fever for inclusion geometric mean GMT ratio GMTs group groups healthy children hospital Hyderabad immunogenicity immunosuppressive inactivated Inactivated vaccine India Infection injection site pain intramuscular dose less Local local reaction male Mild Mild-to-moderate multicentre neutralisation test neutralising antibody response neutralising antibody titre no difference Open-label Pain pandemic participant Phase 2 study phase 2/3 platform positive PRNT Reactions reactogenicity reduction Registered registry reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 vaccine second dose Serious Adverse Events seroconverted serology test serum sample severity of COVID-19 susceptible Symptom three group titre Trial were excluded Withdrawal [DOI] 10.1016/S1473-3099(22)00307-3 PMC 바로가기 [Article Type] Clinical Trial
A retrospective analysis of metabolic control in children with PKU in the COVID-19 eraResearch article Published on 2022-09-012022-10-05 Journal: Molecular Genetics and Metabolism Reports [Category] 변종, 유전자 메커니즘, [키워드] addition age Analysis Blood changes in children classical Compliance COVID-19 COVID-19 pandemic cumulative Diagnosis diagnostic eight Factor Frequency group groups highest introduced lockdown maintain measure median Metabolic control Neonate Newborn Non-COVID-19 pandemic Patient patients Phenylketonuria Prevent remained Result Retrospective analysis significant negative correlation significantly therapeutic were assessed [DOI] 10.1016/j.ymgmr.2022.100897 [Article Type] Research article
Perspectives of healthcare providers on implementation of long-acting cabotegravir plus rilpivirine in US healthcare settings from a Hybrid III Implementation-effectiveness study (CUSTOMIZE)Article Published on 2022-09-012022-11-15 Journal: Journal of the International AIDS Society [Category] 치료제, [키워드] acceptability AIDS antiretroviral Antiretroviral therapy appropriateness assessment barrier baseline change clinics conducted COVID-19 pandemic eight evaluated feasibility finding FIVE foundation Health healthcare Healthcare provider HIV-1 hybrid implementation injection Intervention maintain Measures Month MOST Nurse occurred outcome Pain participant Patient Physicians positive Program Sustainability proportion Quantitative regimen reported single-arm sustainability total score Treatment [DOI] 10.1002/jia2.26003 PMC 바로가기