enrichment – Page 6 – Communicable Diseases Research

Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation

SARS-CoV-2 전파를 억제하기 위한 스트레스 과립 단백질 G3BP1/2의 유전체학 유도 표적화

Article

Published on 2021-11-012022-09-11
Journal: International journal of biological macromolecules [Category] SARS, 유전자 메커니즘, 치료법,

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

SARS-CoV-2 Δ382 변이 감염이 있는 COVID-19 환자의 강력한 바이러스 특이적 적응 면역

Original Article

Published on 2021-10-302022-09-10
Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Antibody Response CD4⁺ T cell response CD8⁺ T cell response coronavirus correlated COVID-19 COVID-19 patients Cytokines disease phenotype dominant enrichment eukaryotic eukaryotic initiation factor 2 evidenced host immunity Host–pathogen interaction identify immune immune signature Immunity initiation factor less molecular Mutation nucleotide deletion ORF7b ORF8 pandemic progresse Patient pro-inflammatory cytokines profile provide Region respiratory RNA-sequencing robust SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Signaling spike mutations supplementary material systemic inflammation systemic level T cell therapeutic target Transcriptome upregulated variants of concern VOCs was performed whole blood transcriptomic wildtype Δ382
[DOI] 10.1007/s10875-021-01142-z PMC 바로가기 [Article Type] Original Article

BPIFB4 Circulating Levels and Its Prognostic Relevance in COVID-19

BPIFB4 순환 수준 및 COVID-19에서의 예후 관련성

THE JOURNAL OF GERONTOLOGY: Biological Sciences

Published on 2021-10-162022-09-10
Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 바이오마커, 변종,

[키워드] aging animal models BPIFB4 CD69 cell lines characterized circulating Comorbidities Comorbidity contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytotoxicity deleterious inflammation demonstrated develop disease severity downregulation early stage early stages enrichment event Evidence Genotype Haplotype healthy healthy control homeostatic homozygous IL-18 IL-1B Immunity function immunomodulatory in vitro individual infected cells Inflammation Inflammatory response inflammatory stimuli involved less Level Longevity lysate lysates MCP-1 minor allele minor alleles Missense mononuclear cell mononuclear cells Mortality open Peripheral blood plasma plasma concentration polymorphism Prognostic value progression of disease Protective Protein rapid increase Recombinant protein reduction Relevance risk of COVID-19 SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells selected senescence shown significantly significantly higher single-nucleotide single-nucleotide polymorphism susceptible T cell T cells target cell TCD4 TCD8 therapeutic therapeutic use variant virus infection
[DOI] 10.1093/gerona/glab208 PMC 바로가기 [Article Type] THE JOURNAL OF GERONTOLOGY: Biological Sciences

Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment Platform

바이러스 농축 플랫폼을 사용한 빠른 CovID-19 분자 진단 시스템

Article

Published on 2021-10-062022-09-01
Journal: Biosensors [Category] 진단, 치료기술, 치료제,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus alleviate amplify caused clinic Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect diagnosis of COVID-19 diagnostic diagnostic test diagnostic tests enrichment fluoride hand healthcare hydrophilic Infection isothermal amplification LAMP lateral flow Loop-mediated isothermal amplification medical staff molecular molecular diagnostics myriad nasopharyngeal nucleic acid nucleic acid amplification pandemic pandemic era platform Prevent public health Rapid rapid diagnostics reduce respiratory reverse transcription RNA RNA extraction robust sample preparation SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimens Spread System therapeutic intervention virus virus enrichment viruses
[DOI] 10.3390/bios11100373 PMC 바로가기 [Article Type] Article

Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment Platform

Article

Published on 2021-10-062022-10-27
Journal: Biosensors [Category] COVID-19,

Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment Platform

Article

Published on 2021-10-062022-10-27
Journal: Biosensors [Category] Coronavirus, COVID-19, MERS, SARS,

Variability in Codon Usage in Coronaviruses Is Mainly Driven by Mutational Bias and Selective Constraints on CpG Dinucleotide

코로나 바이러스에서 코돈 사용의 가변성은 주로 CPG 디 뉴클레오티드의 돌연변이 바이어스 및 선택적 제약에 의해 주도된다.

Article

Published on 2021-09-102022-09-10
Journal: Viruses [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptation avoidance Bia breadth codon codon usage Codon usage bias comprehensive analysis Coronaviridae family coronavirus coronavirus disease Coronavirus disease 2019 coronavirus genome coronavirus genomes Coronaviruses COVID-19 CpG Critical dependent on dinucleotide Endemic enrichment explain Frequency Host host switch hosts human coronavirus human coronaviruses humans identify infecting mammalian mutational bia Mutational bias Neutral Orthocoronavirinae pandemic primary host respiratory risk SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synonymous the Coronaviridae total variation Usage Variation virus Virus evolution viruses zoonotic
[DOI] 10.3390/v13091800 PMC 바로가기 [Article Type] Article

Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune Cells

SARS-COV-2 진입 인자의 농축 및 조직에서 세포 내 유전자 상호 작용 및 순환 면역 세포

Article

Published on 2021-09-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes

기존 제2형 당뇨병과 SARS-CoV-2 감염에 대한 시너지적 복잡성의 분자적 통찰력 확인

Article

Published on 2021-09-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 치료기술,

[키워드] activities Analysis analyzed approaches association bioinformatics BIRC3 caused Cell Comorbidities Comorbidity conditions contributing to COVID-19 COVID-19 outbreak CREB3L1 cytokine cytokine receptor DEGs detect determine diabete diabetes differentially expressed gene Differentially expressed genes Disease progression drug drug candidate drug candidates Drug molecules enrichment enrichment analyses evaluated expressed Factor followed by FOSL1 Functional enrichment analysis Genetic genetic determinant genetic factors global public health Health identify identifying IL-17 IL1B Interaction IRF1 islet cell KLF11 let-7b-5p lung epithelium cell lung epithelium cells microRNA MicroRNAs miR-1 miRNA miRNAs MME molecular overlapped pancreatic pancreatic islet Pathways Patient PBMC PBMCs PPI prevalent protein-protein interaction protein–protein interactions receptor Research SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 significant pathway significant pathways synergistic T2D TFS the disease therapeutic intervention TNF transcription factor transcription factors transcriptomic data Type type 2 diabete type 2 diabetes
[DOI] 10.1016/j.compbiomed.2021.104668 PMC 바로가기 [Article Type] Article

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)

어린이의 다기관 염증 증후군(MIS-C)에 대한 유전적 감수성의 기본 메커니즘

Article

Published on 2021-09-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Apoptosis Beta cardiovascular dysfunction characterized children cohort of patient condition coronavirus COVID-19 CYBB cytokine cytokine signaling Deleterious develop Diagnosis differentially expressed gene Differentially expressed genes downstream enrichment enrolled Exome General population Genetic genetic mechanism genetic risk factor genetic susceptibility had no haploinsufficiency healthy children identify IL-18 Immune cell Including Infection Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibitor interferons interquartile range median age Mild MIS-C Multiorgan multisystem inflammatory syndrome in children Next-generation sequencing nuclear obesity occur pathway Pathways Patient PBMC PBMCs pediatric prospective cohort study reported respiratory SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus single-center SOCS1 subunit Support suppressor susceptibility syndrome Transcriptome type I variant was performed was tested whole exome sequencing X-linked XIAP
[DOI] 10.1016/j.jaci.2021.06.024 PMC 바로가기 [Article Type] Article