The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pHArticle Published on 2021-03-242023-06-15 Journal: The Journal of Physiology [Category] MERS, SARS, [키워드] envelope protein ion channel membrane targeting SARS‐CoV‐2 [DOI] 10.1113/JP281037 PMC 바로가기
Immunoinformatic approach to design a multiepitope vaccine targeting non-mutational hotspot regions of structural and non-structural proteins of the SARS CoV2Bioinformatics Published on 2021-03-232022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 3D structure Analysis Antigen antigen processing antigenicity approach B cell binding affinity binding energy calculated caused Cell complex coronavirus 2 cross-reactivity database demonstrated docking envelope protein epitope Epitopes evaluated Extracellular high mortality HLA host cell hotspot IFN immune response Immune simulation induce Infection injection interacting residue Interaction leukocyte linker MDs Membrane proteins memory Microbiome Molecular dynamics simulation morbidity multiepitope vaccine Mutation mutations non-structural protein ORF1ab polyprotein ORF3a protein ORF8 protein outbreak pandemic Physicochemical properties predicted Protein proteomics Region respiratory Result SARS CoV2 screened selected sensitivity Seven similarity strong immune response Study design Surface glycoprotein T cell the vaccine TLR TLRs Toll-like receptor Toxicity vaccination Vaccine vaccine construct virus was performed [DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics
A cross-neutralizing antibody between HIV-1 and influenza virusResearch Article Published on 2021-03-222022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Analysis antibodies antibody Antigen antigenic evolution approaches Cluster compose Comprehensive conserved cross-neutralizing envelope envelope protein epitope Evolution glycan glycans glycosylated glycosylation site H3N2 H3N2 strain HIV-1 immune response immunogenic influenza hemagglutinin Influenza virus Isolation N -glycosylation negative-stain electron microscopy neutralize neutralizing antibody pandemic Patient persistence Protein provided RBS receptor binding site required Seasonal influenza Spread Strains sugars Surface glycoprotein survival target Vaccines viral pathogens viral surface virus viruses [DOI] 10.1371/journal.ppat.1009407 PMC 바로가기 [Article Type] Research Article
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2동반 질환은 SARS-CoV-2에 대한 적응 면역 반응의 변화와 관련이 있습니다.Research Article Published on 2021-03-222022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료법, [키워드] Adaptive immune response Adaptive immunity age Analysis antibody Antibody Response Antibody responses Beta cells breadth CD4 Clinical outcome Cohort Comorbidities convalescent COVID-19 death diabetes envelope protein envelope proteins Ethnicity flow cytometry function functional functions Hospitalization Hospitalized illness illnesses immune system immunology magnitude nucleocapsid obesity reduced risk factor S1 domain SARS-CoV-2 serology severe COVID-19 Sex subject subjects symptom onset T cell T cells These data [DOI] 10.1172/jci.insight.146242 PMC 바로가기 [Article Type] Research Article
Structure insights of SARS-CoV-2 open state envelope protein and inhibiting through active phytochemical of ayurvedic medicinal plants from Withania somniferaOriginal Article Published on 2021-03-182022-10-28 Journal: Saudi Journal of Biological Sciences [Category] COVID-19, [키워드] Antiviral bind bioinformatics block blocking computational tools COVID-19 infections docked E protein ENCODE envelope protein globe Host hydrophobic inhibiting inhibitor molecular pandemic plant progeny Protein Protein Informatics public health Replication residues SARS-CoV-2 SARS-COV-2 infection Structure target the SARS-CoV-2 the SARS-CoV-2 virus these compound Vaccine development virus virus replication Withania somnifera [DOI] 10.1016/j.sjbs.2021.03.036 PMC 바로가기 [Article Type] Original Article
An Overview of Spike Surface Glycoprotein in Severe Acute Respiratory Syndrome–CoronavirusMolecular Biosciences Published on 2021-03-162022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] antiviral drug binding China cleaved contagious Corona coronavirus CoV COVID-19 disease drug design ENCODE entry inhibitors envelope protein enzyme Genetic Genome highest Host host cell host cell receptor include inhibit inhibitor initial involved membrane protein MERS monomer mortality rate non-structural protein non-structural proteins Novel coronavirus nucleocapsid protein predominant protease researcher respiratory S1 and S2 S1 domain S1/S2 S2 domain SARS-CoV-2 shown small molecule spike spike (S) glycoprotein structural protein structural proteins subunit surface Surface glycoprotein target the S protein the WHO therapeutic treat Treatment Vaccine viral genome viral infection viral infections virulent virus [DOI] 10.3389/fmolb.2021.637550 PMC 바로가기 [Article Type] Molecular Biosciences
The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2Bromelain과 Acetylcysteine(BromAc)의 조합은 SARS-CoV-2를 상승적으로 비활성화합니다Article Published on 2021-03-062022-09-10 Journal: Viruses [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 receptor Acetylcysteine acute respiratory syndrome acute respiratory syndrome coronavirus administration binding breakage BromAc Bromelain clinical clinical testing coronavirus Culture demonstrated determine Disulfide disulfide bond Drug repurposing envelope protein envelope proteins glycoprotein Glycoproteins glycosidic host cell host cells in vitro inactivation Infection nasal nasal mucosa Patient recombinant reduce reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus spike spike glycoprotein spike mutants synergistic synergistic action therapeutic options Treatment virus virus culture wild-type worldwide pandemic [DOI] 10.3390/v13030425 PMC 바로가기 [Article Type] Article
Population-Predicted MHC Class II Epitope Presentation of SARS-CoV-2 Structural Proteins Correlates to the Case Fatality Rates of COVID-19 in Different CountriesCommunication Published on 2021-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Adaptive immune response allele B-cell Case fatality rate country COVID-19 distributions early infection early phase envelope protein epitope epitope mapping Factor Fatality rate health system highlight histocompatibility immunological Infection infection spread lethality rate Linear regression Local Major measure membrane protein MHC class MHC class II MHC I MHC II MHCII Other Population population coverage potential risk predicted presentation Rate SARS-CoV-2 SARS-CoV-2 protein significant negative correlation Spread structural protein T-cell the SARS-CoV-2 viral envelope proteins viral spike protein [DOI] 10.3390/ijms22052630 PMC 바로가기 [Article Type] Communication
Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effectsArticle Published on 2021-02-182022-10-04 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] analysed Analysis approach caused codon usage Comorbidity Computational study deaths deregulated determine Effect envelope protein expressed expressed gene facilitated feature Functional clustering Genes Genetic genetic variability glycoprotein Host host cell human cell human gene Human genetics human lung tissue identify individual infect International lung tissues membrane MERS molecular feature occurred outbreak overexpressed pneumonia case predict Protein public health emergency Replication Research reveal rising SARS-CoV-2 selected similarity Spread susceptible the SARS-CoV-2 tissue translation viral gene viral infection viral infections viral replication virus WHO Wuhan, China β-coronavirus [DOI] 10.1038/s41598-021-83595-1 PMC 바로가기 [Article Type] Article
MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid proteinResearch Paper Published on 2021-02-062022-10-28 Journal: Theranostics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Betacoronavirus C-terminal domain can be used Cell co-immunoprecipitation conducted coronavirus Coronaviruses determine develop envelope protein homology immunostaining in vitro infected cells inhibit inhibited Interaction investigated Lineage MERS-CoV MERS-CoV-infected cells Middle East molecular interaction N protein N proteins nucleocapsid nucleocapsid protein penetration peptide produced Protein proteomics Replication respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells spike Spike protein Strains synthetic peptide targeting the N protein the S protein the SARS-CoV-2 the Spike Viral protein viral spike protein virus virus infection virus production virus replication [DOI] 10.7150/thno.55647 PMC 바로가기 [Article Type] Research Paper