A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
Article
[키워드] 100% conserved
Analysis
Antigen
Beta
caused
CD4
CD4+
CD8
CD8+ T cell
clade
clades
composed
confirmed cases
conserved
COVID-19
cross-protective
deaths
Delta
epitope
Epitopes
Epsilon
Eta
Gamma
Genome
genomes
GISAID
greater
highly antigenic
HLA binding
hydrophobic
IFN-γ
IL-10
IL-12
IL-2
IL-6
immune response
immune responses
immunoinformatics
in silico approaches
in vivo
Lambda
long-lasting
majority
memory
Metadata
molecular docking
Mortality
Mutation
non-toxic
offer
omicron
ORF
ORF1ab
ORF8 proteins
peptide
performed
promoted
Protein
reduced
Reinfection
SARS-CoV-2
SARS-CoV-2 genome
SARS-CoV-2 variants
secretion
severity
Strains
suffered
T cell epitope
TGF-β
Th1
the Spike
the vaccine
TLR4
Vaccine
variant
variants
virus
virus transmission
WHO
Wuhan
[DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
[DOI] 10.1038/s41598-022-21207-2 PMC 바로가기