SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study프랑스 전국 봉쇄 기간 동안 어린이집 어린이와 직원 간 SARS-CoV-2 전파: 횡단면, 다기관, 혈청 유병률 연구Clinical Trial Published on 2021-04-012022-09-12 Journal: The Lancet. Child & adolescent health [Category] MERS, SARS, 임상, 진단, [키워드] 95% CI Abstract age antibody assistance Bayesian Characteristics children Comparator group contribute COVID-19 CrI cross-sectional Denis enrolled Epidemiological study exploratory Exploratory analysis France French Hypothesis IgG IgM test immunoassay individual laboratory-confirmed lockdown material multicentre nine Paris participant patients with COVID-19 positive presence of antibody Prevalence Primary outcome proportion Registered remained risk Saint SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 seroprevalence SARS-CoV-2 transmission Seine Sensitivity and specificity serological test seronegative seropositive suggested translation Transmission transmission of SARS-CoV-2 was measured Whole blood [DOI] 10.1016/S2352-4642(21)00024-9 PMC 바로가기 [Article Type] Clinical Trial
Trajectories of eating behavior during COVID-19 lockdown: Longitudinal analyses of 22,374 adultsOriginal Article Published on 2021-04-012022-11-01 Journal: Clinical nutrition ESPEN [Category] Coronavirus, MERS, SARS, [키워드] Analysis analyzed changes in Chronic diseases class COVID-19 COVID-19 pandemic Covid-19 social study depressive symptom eating behavior effort events Exploratory analysis Factor finding FIVE greater highlight identify implementation Latent less lockdown longitudinal majority Measures mental health multinomial regression pandemic Pandemics participant Prevent Psychological public health Result risk factor secondary suggested Support Trajectories trajectory UCL was used [DOI] 10.1016/j.clnesp.2021.01.046 PMC 바로가기 [Article Type] Original Article
Cerebrospinal fluid findings in patients with psychotic symptoms—a retrospective analysisArticle Published on 2021-03-302022-10-04 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] affecting analyzed autoantibodies Autoimmune Autoimmunity Biomarker Biomarkers cause caused Characteristics COVID-19 criteria CSF CSF analysis delusional description Descriptive analysis detect diagnosed diagnosing diagnostic Diagnostic Criteria diagnostic workup disorder disorders etiological Exploratory analysis Factor Gender help Human behaviour ICD-10 identify IMPROVE Infectious diseases Inflammation International Ischemia multiple sclerosis neurological manifestations NEUROLOGY neurosyphilis NMDA Older parameter Pathogenesis pathology Patient patients physiological physiological conditions Psychology remained retrospective Retrospective analysis Schizophrenia significantly more specificity Symptom symptomatic Symptoms tissue Treatment while [DOI] 10.1038/s41598-021-86170-w PMC 바로가기 [Article Type] Article
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials단회 투여 및 ChAdOx1 nCoV-19(AZD1222) 백신의 면역원성 및 효능에 대한 추가 투여 시간의 영향: 4건의 무작위 시험에 대한 통합 분석Meta-Analysis Published on 2021-03-062022-09-10 Journal: Lancet (London, England) [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI addition administration Ageusia All participants Analysis Anosmia antibody antibody levels Antibody Response Antibody responses approved assigned AstraZeneca AZD1222 baseline binding antibody booster dose booster doses Brazil category ChAdOx1 ChAdOx1 nCoV-19 Clinical research Coalition control group control vaccine cough COV005 COVID-19 COVID-19 disease COVID-19-related death Cutoff death defined described dose doses double-blind Efficacy Emergency use Endpoint Evidence evidence of exclusion exploratory Exploratory analyses Exploratory analysis Fever finding first dose FIVE Follow-up for inclusion foundation funding geometric mean geometric mean ratio GMR had no Hospital admission immunoassay immunogenicity immunogenicity data independent indicated individual Infection initial Innovation interim analysis ISRCTN89951424 less lower dose Medicine Medicines Medicines and Healthcare products Regulatory Agency Melinda Gate Melinda Gates N protein NAAT NAAT-positive swab network neutralisation NIHR no evidence of nucleic acid nucleic acid amplification nucleic acid amplification test observation offered Older outcomes Oxford pandemic participant phase 2/3 phase 3 study positive swab primary analysis primary endpoint Primary outcome prime-boost interval priming PROTECT pseudovirus randomised controlled Randomised trial Randomly receive receiving recruited regimen Registered regulatory authority response Safety saline placebo SARS-COV-2 infection SARS-CoV-2 N protein second dose secondary Serious Adverse Events seronegative Seven Shortness of breath single-blind Single-dose South South Africa Standard dose subset supported Swab swabs Symptom symptomatic COVID-19 disease symptomatic infection Telle the primary endpoint the timing the vaccine Trial vaccination Vaccine vaccine efficacy Valley Viral Viral particles [DOI] 10.1016/S0140-6736(21)00432-3 PMC 바로가기 [Article Type] Meta-Analysis
Prevalence of Venous Thromboembolism in Critically Ill COVID-19 Patients: Systematic Review and Meta-AnalysisCardiovascular Medicine Published on 2021-01-082022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI Analysis Cohort confidence interval coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill Deep venous thrombosis dosage DVT—deep vein thrombosis event Exploratory analysis ICU Ill item Meta-analysis Patient patients performed Prevalence prevalence rates Prophylactic proportion Randomized controlled trials recent reduce remains uncertain Reporting review SARS-CoV-2 searched significantly subgroup analysis systematic review therapeutic anticoagulation Thromboprophylaxis thrombosis venous Venous Thromboembolism VTE VTE risk [DOI] 10.3389/fcvm.2020.598846 PMC 바로가기 [Article Type] Cardiovascular Medicine
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome Adenovirus Adults antibody production Antibody Response antigen-specific T cell AZD1222 caused CD4+ T cell CD8+ T cells cell-mediated immune cell-mediated immune response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical trial contribute coronavirus COVID-19 cytokine secretion Cytotoxic T cell disease effective vaccine Efficacy Exploratory analysis expressing full-length SARS-CoV-2 global pandemic host cell humoral IgG1 IgG3 Immune profile immune response immunogenicity data infected with SARS-CoV-2 interferon-γ neutralizing antibody Patient phase 2/3 trial Phenotypes progression Protective protective role reduce reported Safe SARS-CoV-2 SARS-CoV-2 vaccine single dose Spike protein Strong suggested T cell T cell response the SARS-CoV-2 Trial tumor necrosis factor-α two-dose regimen vaccination Vaccine vaccine candidate [DOI] 10.1038/s41591-020-01194-5 [Article Type] Research
Visual Analytic Tools and Techniques in Population Health and Health Services Research: Scoping ReviewReview Published on 2020-12-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] analyses applied article articles assist automated Care Characteristics complex COVID-19 Critical Data mining Data visualization Epidemiology Exploratory analysis greater Health Health Service Health services research HSR Identifier include indicate involved item knowledge machine learning methodological mobile phone MOST objective peer-reviewed platform Population Population health promote provided report Reporting Research researcher Result review service spatiotemporal Support Surveillance technique Visual visual analytics [DOI] 10.2196/17892 PMC 바로가기 [Article Type] Review
Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York CityObservational Study Published on 2020-12-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 95% CI acute renal failure adjusted odds ratio Admission age Analysis assessment association body mass index chi-square tests coronavirus disease correlated discharge home Encephalopathy Exploratory analysis failure Gender Health hospital hyponatremia identify Impact In-hospital death in-hospital mortality increased risk Increasing independent interleukin-6 Invasive mechanical ventilation Kruskal-Wallis laboratory abnormalities laboratory-confirmed measurement mechanical ventilation Mild moderate morbidity and mortality multicenter multivariable logistic regression New York City nonosmotic normonatremia Observational cohort study occur occurred outcome past medical history Patient patients patients with pneumonia predictors Prevalence Primary outcome Probability renal required secondary severity sodium sodium level worsening [DOI] 10.1097/CCM.0000000000004605 PMC 바로가기 [Article Type] Observational Study
Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the INSPIRATION/INSPIRATION-S studiesCOVID-19 중증 환자에서 중간 용량 대 표준 용량 예방적 항응고제 및 스타틴 요법 대 위약: INSPIRATION/INSPIRATION-S 연구의 이론적 근거 및 설계Article Published on 2020-12-012022-09-11 Journal: Thrombosis research [Category] 임상, [키워드] all-cause mortality Analysis anticoagulation antithrombotic therapy Arterial thrombosis atorvastatin bleeding Chain Reaction cohorts Composite Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 death double-blind eligibility criteria Enrollment Exploratory analyses Exploratory analysis extracorporeal membrane oxygenation factorial design hallmark hallmarks help hypothese Hypothesis immune response include independent inferiority inspiration intensity intention-to-treat intermediate limit liver enzyme liver enzymes major bleeding management manifestation matching placebo modified intention-to-treat Myopathy non-inferiority non-inferiority margin normal limit Odds ratio open open label Patient patients with COVID-19 per-protocol performed Placebo Platelet Platelet count polymerase chain polymerase chain reaction Prevent primary endpoint Prophylactic prophylactic anticoagulation question randomization Randomized Randomized controlled trial rationale Result reverse transcription reverse transcription polymerase chain reaction safety endpoint screened secondary endpoint Standard dose Standard-dose statin Stratified randomization subgroup tested therapy thrombocytopenia thrombosis thrombotic event Thrombotic events undergo Venous Thromboembolism Ventilator-free days VTE [DOI] 10.1016/j.thromres.2020.09.027 PMC 바로가기 [Article Type] Article
Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational studyObservational Study Published on 2020-12-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Coronavirus, Fulltext, MERS, 임상, [키워드] acute respiratory distress analysed ARDS baseline calculate cause Classifier Cohort collected Concentration COVID-19 COVID-19-associated ARDS Critically ill patient Cutoff demographic described died eight Exploratory analysis FIVE Health Hyperinflammatory identify IL-6 inflammatory pathway inspired air intensive care units interleukin-6 IQR laboratory data median Mortality multicentre multiorgan failure Necrosis Older oxygen PaO Patient patients patients with ARDS phenotype Phenotypes point-of-care Prevalence Probability proportion prospective observational study randomised controlled trial receptor recruited severity significantly lower Survivors syndrome systemic inflammation TNFR1 unlikely upregulation was used [DOI] 10.1016/S2213-2600(20)30366-0 PMC 바로가기 [Article Type] Observational Study