Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients호중구 세포외 트랩의 혈장 표지자는 COVID-19 관련 ARDS 환자의 생존과 관련이 있지만 폐색전증과는 관련이 없습니다Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Admission Analysis ARDS Biomarker circulating Clinical outcome clinical outcomes collected Comparisons complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression develop Embolism evaluate Extracellular hospital hospitalized COVID-19 patient hospitalized COVID-19 patients Hypothesis immunothrombosis life-threatening lung damage Mann-Whitney test marker microthrombus moderate disease myeloperoxidase NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps non-survivor Non-survivors Occurrence Patient patients patients hospitalized plasma Plasma levels Prevent pulmonary Pulmonary embolism recent respiratory distress Respiratory distress syndrome responsible restriction severe COVID-19 patients severe disease severe patients survival survivor syndrome therapeutic target total DNA TRAP were assessed with COVID-19 worsening [DOI] 10.3389/fimmu.2022.851497 PMC 바로가기 [Article Type] Article
Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infectionCovid19 감염 초기 단계의 새로운 국소 치료 전략의 기초로서 시험관 내 다양한 광원에서 세포 내 B-CoV 및 SARS-CoV2 바이러스에 대한 메틸렌 블루 기반 광역학 불활화(PDI) 평가Article Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] Antiviral aPDT (antimicrobial photodynamic therapy). approach Cell Concentration Corona viruses dark dose early phase experiment Extracellular in vitro inactivation Incubation infected cell infected cells Infection intensity Laser Local logarithmic reduction low dose Methylene Methylene blue nose and throat PDI PDI (photodynamic inactivation) phenothiazine Phenothiazine dye in aPDT photodynamic inactivation photodynamic therapy photosensitizer Prognosis radiation intensity reducing reduction SARS-CoV-2 SARS-CoV-2 inactivation SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV2 sensitizer substitute therapy treated treatment strategy Vero E6 Viral load virus was reduced [DOI] 10.1016/j.pdpdt.2021.102642 PMC 바로가기 [Article Type] Article
Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 InfectivityArticle Published on 2022-02-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 3CLpro ACE2 acid acute respiratory syndrome angiotensin-converting enzyme 2 approach bind binding biochemical building cell membrane Combination Compound coronavirus coronavirus disease COVID-19 Effect Extracellular higher affinity Host Infectivity inhibit Inhibition assays inhibitors Interaction involved Ligand molecular molecular docking molecular dynamics organism pandemic physicochemical polyphenols Prevent protease RBD Receptor binding domain Replication SARS-CoV-2 SARS-CoV-2 cell serine 2 Spike protein Structural properties target target receptor targets the SARS-CoV-2 TMPRSS2 transmembrane [DOI] 10.3390/ijms23052643 PMC 바로가기 [Article Type] Article
Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) TherapyReview Published on 2022-02-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Alpha anti-inflammatory effect Anti-inflammatory effects application can be used cell fragments Critical Diseases Extracellular Factor Factors Granule Hemostasis in viral include induce knowledge microparticles microvesicle Platelet Platelets pro-inflammatory provide reduce role suppress target therapy thrombosis Vesicle vesicles viral infection viral infections virus while [DOI] 10.3390/ijms23042321 PMC 바로가기 [Article Type] Review
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccinationArticle Published on 2022-02-082022-10-04 Journal: NPJ Vaccines [Category] 바이오마커, [키워드] Activation adjuvants Adverse reaction Adverse reactions antibody production Antibody titers Biomarker BNT162b2 circulating conducted correlated COVID-19 COVID-19 vaccination Efficacy EVs Extracellular extracellular vesicle Fever immune responses less local pain lymphocyte microRNA miRNA mRNA-based vaccine Pain pandemic Proinflammatory cytokine prospective cohort study RNA vaccines second dose sera serum systemic adverse reaction systemic symptoms TNF-α Vaccine vaccine efficacy Vesicle [DOI] 10.1038/s41541-022-00439-3 PMC 바로가기 [Article Type] Article
Synthetic molecule libraries for nucleic acid delivery: Design parameters in cationic/ionizable lipids and polymersReview article Published on 2022-02-012022-10-05 Journal: Drug metabolism and pharmacokinetics [Category] 비임상, [키워드] biodegradability Cationic lipid Cationic polymer described develop drug Extracellular facilitate hydrophobicity in vitro in vivo Lipid Liver disease mechanism nanomedicine nanoparticle Nuclease nucleic acid Nucleic acid delivery Other parameter Polymer PROTECT recent Structure synthetic translated Treatment virus infection [DOI] 10.1016/j.dmpk.2021.100428 [Article Type] Review article
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays분자 도킹, 세포내 및 세포외 분석을 통한 SARS-CoV-2 3CL 프로테아제 억제제로서의 동백나무 카테킨 발견Article Published on 2022-02-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 치료기술, [키워드] (-)-epicatechin (–)-epicatechin 3-O-caffeoate 3CL 3CLpro Amino acid amino acid residue amino acid residues ASN142 AutoDock binding energy Camellia Camellia sinensis catechins cellular chymotrypsin conducted configuration cysteine cysteine protease detection system dissociation Dissociation constant Ebselen ebselen. ECG Epicatechin Extracellular gallate GCG GLN189 Gly143 HIS163 inhibit inhibitors inhibitory activity Modification molecular docking Previous studies previous study Protease inhibitor SARS-CoV-2 selected SPR suggested surface plasmon surface plasmon resonance THR26 was used [DOI] 10.1016/j.phymed.2021.153853 PMC 바로가기 [Article Type] Article
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
Modulation of Macrophage Immunometabolism: A New Approach to Fight InfectionsImmunology Published on 2022-01-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulated amino acid metabolism Bacterial contribute Defense develop drug Evidence Extracellular fatty acid oxidation function Glycolysis Host immune function Immunity immunometabolism Infection infections innate immune cell Macrophage macrophage activation metabolic pathway New pentose phosphate pathway phenotype potential therapy regulate respond SARS – CoV – 2 SARS-CoV2 infection Therapeutic strategies Therapeutics viral infection [DOI] 10.3389/fimmu.2022.780839 PMC 바로가기 [Article Type] Immunology
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article