Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis세포외 기질 리모델링 및 상처 치유의 바이오마커를 사용하여 SARS-CoV-2에 감염된 고위험 환자를 식별할 수 있습니까?: 폐 섬유증에서 얻은 교훈Review Published on 2021-02-052022-09-10 Journal: Respiratory Research [Category] MERS, 바이오마커, [키워드] acute deterioration acute respiratory syndrome admittance Biomarker Biomarkers Can Care ECM Extracellular matrix fibrosis high risk ICU identify Infection intensive care intensive care unit Interstitial lung disease Interstitial lung diseases life lung Lung diseases Lung function Lungs matrix Medical care medical need morbidity and mortality Mortality Non-invasive Patient poor quality Post-infection predict pulmonary pulmonary dysfunction pulmonary fibrosis Quality of life Research respiratory risk Sand SARS-Co SARS-Co-V2 SARS-COV-2 infection serological Severe acute respiratory syndrome shown subsequent tissue remodelling Treatment wound healing [DOI] 10.1186/s12931-020-01590-y PMC 바로가기 [Article Type] Review
Unraveled roles of hyaluronan in severe COVID-19Review Article Published on 2021-01-152022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] 4-methylumbelliferone acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome ARDS association caused Chest coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokine storm ECM Extracellular matrix high mortality rate Hyaluronan hyaluronidase IMPROVE Inflammation lung MOST pandemic pathophysiology patients respiratory airway SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient severe patients survival rate syndrome therapeutic potential Viral pneumonia [DOI] 10.17179/excli2020-3215 PMC 바로가기 [Article Type] Review Article
Mechanic Forces Promote Brain Endothelial Activation by SARS-CoV-2 Spike ProteinEditorial Published on 2021-01-012023-07-11 Journal: Stroke [Category] SARS, [키워드] Brain Editorials endothelial cells Extracellular matrix Inflammation [DOI] 10.1161/STROKEAHA.120.033119 [Article Type] Editorial
Molecular Mechanisms of Proteins — Targets for SARS-CoV-2 (Review)단백질의 분자 메커니즘 — SARS-CoV-2의 표적(검토)Review Published on 2020-12-282022-09-10 Journal: Modern Technologies in Medicine [Category] MERS, SARS, 치료기술, 치료제, [키워드] accumulating ACE2 Activation Affect affected angiotensin Angiotensin 1-7 Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 astrogliosis basal ganglia blood-brain barrier Brain brain damage brain damage in COVID-19 brain tissue breakdown caused CD147 Central nervous system Cerebellum change CNS coronavirus Coronavirus infection COVID-19 Cytokines damage death develop disease Diseases driven by Endothelial cell endothelial cells enzyme Evidence exposure to expressed Extracellular matrix functional ganglia help hypothalamus inducer Infection information interactions leads leukocyte leukocytes Local massive matrix metalloproteinases mechanisms membrane permeability metabolism microglia midbrain molecular mechanism molecular mechanisms moment nasal epithelium Neuroinflammation neurons Neurovascular New coronavirus new coronavirus SARS-CoV-2 pathogen Pathogenesis pathogenesis of COVID-19 Piriform cortex Proinflammatory cytokine proinflammatory cytokines pulmonary symptoms Research review SARS-CoV-2 Serine serine protease serine protease TMPRSS2 substantia substantia nigra target target proteins the disease TMPRSS2 Treatment Vascular Via virus virus spread [DOI] 10.17691/stm2020.12.6.11 PMC 바로가기 [Article Type] Review
Lung transplantation for patients with severe COVID-19중증 코로나19 환자를 위한 폐 이식Case Reports Published on 2020-12-162022-09-12 Journal: Science Translational Medicine [Category] MERS, 진단, [키워드] Allograft Bharat biopsy can not Cell concern conducted COVID-19 COVID-19 disease detect develop died Evidence evidence of Extracellular matrix fibrosis FIVE Gene Expression In situ hybridization include Infection Injury life lineages lung Lung disease Lung injury lung tissue lung tissue samples lung transplantation Lungs machine learning mechanical ventilation outcome pathogen Pathogens pathology Patient patients performed Pneumonia positive potential risk pulmonary fibrosis recurrence Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe COVID-19 similarities similarity Single-cell RNA sequencing Support surgical survival therapy transcriptional change Transcriptional changes Transplant transplantation Treatment two patients Ventilator-associated pneumonia warm [DOI] 10.1126/scitranslmed.abe4282 PMC 바로가기 [Article Type] Case Reports
Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils신디케인-1은 부착성 피브로넥틴 섬유의 조립을 촉진하여 폐렴구균 각막 감염을 촉진한다.Research Article Published on 2020-12-082024-07-30 Journal: mBio [Category] 폐렴구균 감염증, [키워드] Extracellular matrix host-pathogen interactions keratitis proteoglycans syndecans [DOI] 10.1128/mBio.01907-20 PMC 바로가기 [Article Type] Research Article
Cathepsin L in COVID-19: From Pharmacological Evidences to GeneticsCellular and Infection Microbiology Published on 2020-12-082022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition antigen processing Apoptosis ARDS Atherosclerosis cathepsin cathepsin L Cathepsins Cell chronic inflammation coronavirus coronavirus disease COVID-19 COVID-19 patients cysteine protease Cytokine storm Deterioration detrimental diabetes discomfort disease Diseases drug enzyme etiology expression Extracellular matrix host cells host genetics Immunological response immunopathological implicated Infection infections inflammatory status inhibiting Invasion involved late stage lung lysosomal MERS-CoV Metastasis multiple organ failure other diseases Pandemics pathological condition physiological renal respiratory robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein the disease therapeutic target treat tumors up-regulated viral infection [DOI] 10.3389/fcimb.2020.589505 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Pharmacological agents to therapeutic treatment of cardiac injury caused by Covid-19Review article Published on 2020-12-012022-10-05 Journal: Life sciences [Category] SARS, 치료법, [키워드] 2019 coronavirus disease ACE-2 affected angiotensin Cardiac arrhythmia cardiac injury cardiovascular cardiovascular system caused COVID-19 death dysfunction edema effective Ejection fraction electrical enzyme expressed Extracellular matrix fibrosis global pandemic highlighting host cell identify Injury involved lesions Lungs Myocardial other organ other organs pathological Patient penetrate pharmacological reducing Respiratory system responsible SARS-CoV-2 scar severe COVID-19 therapeutic Therapeutic treatment viral infection [DOI] 10.1016/j.lfs.2020.118510 [Article Type] Review article
Extracellular Superoxide Dismutase, the Endothelial Basement Membrane, and the WNT Pathway: New Players in Vascular Normalization and Tumor Infiltration by T-CellsArticle Published on 2020-10-302023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] β-catenin diapedesis Extracellular matrix FoxM1 Immunotherapy Laminin oxidative stress ROS [DOI] 10.3389/fimmu.2020.579552 PMC 바로가기
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosisReview Published on 2020-10-142022-10-30 Journal: Molecular Medicine [Category] Coronavirus, MERS, SARS, [키워드] Activation Alter alveolar cells alveolar epithelium arise capillary Cell cellular COVID-19 patient Critical cytoskeletal Effect endothelial cells Epigenetic epithelial epithelial cells Extracellular matrix fibroblast fibroblasts fibrosis Gas exchange generate Injury Local Lung fibrosis Macrophage Mast cells mechanical stress Mechanical stress niche mechanical ventilation Mild pathology pulmonary pulmonary fibrosis receive Regulation repeated severe hypoxemia stages stem cells subject subsequent Supportive treatment tissue variety vascular permeability [DOI] 10.1186/s10020-020-00223-w PMC 바로가기 [Article Type] Review