Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral HemagglutininArticle Published on 2019-01-112023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Antiviral agents fusion peptide Influenza virus lactoferrin [DOI] 10.3390/v11010051 PMC 바로가기 [Article Type] Article
Gene cloning, expression and immune adjuvant properties of the recombinant fusion peptide Tα1-BLP on avian influenza inactivate virus vaccineArticle Published on 2018-07-012023-06-21 Journal: Microbial pathogenesis [Category] 조류인플루엔자, [키워드] adjuvant Avian influenza vaccine Bursin-like peptide (BLP) fusion peptide Thymosin α1 (Tα1). [DOI] 10.1016/j.micpath.2018.05.003
Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cellsArticle Published on 2017-12-212023-06-14 Journal: Virology [Category] MERS, [키워드] calcium coronavirus Endosomes fusion peptide SARS Spike protein virus entry [DOI] 10.1016/j.virol.2017.12.015 PMC 바로가기 [Article Type] Article
NMR structure and localization of a large fragment of the SARS-CoV fusion protein: Implications in viral cell fusionArticle Published on 2017-10-052023-07-01 Journal: Biochimica et biophysica acta. Biomembranes [Category] SARS, [키워드] Cell fusion CoVs, coronaviruses DPC, dodecyl phosphocholine FPs, fusion peptides fusion peptide fusion protein LFP, long fusion peptide NMR NMR, Nuclear Magnetic Resonance PRE, paramagnetic relaxation enhancement SARS-CoV SARS-CoV, Severe acute respiratory syndrome-associated coronavirus Structure [DOI] 10.1016/j.bbamem.2017.10.002 PMC 바로가기 [Article Type] Article
Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitisResearch Article Published on 2017-08-022022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] 95% CI 95% confidence interval allelic approach Blood calculated Chronic kidney disease coronavirus detect diagnose diagnosed disease effusion evaluate examined Feline coronavirus (FCoV) Feline enteric coronavirus (FECV) Feline infectious peritonitis (FIP) Feline infectious peritonitis virus (FIPV) fusion peptide Mutation negative and positive nucleotide occurred Pathogenesis polymerase chain positive Predictive real-time reverse transcriptase real-time RT-PCR responsible Result Reverse transcriptase polymerase chain reaction (RT-PCR) RT-PCR sensitivity Sensitivity and specificity serum/plasma specificity spike gene Viral load virus [DOI] 10.1186/s12917-017-1147-8 PMC 바로가기 [Article Type] Research Article
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domainsArticle Published on 2017-04-102022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] Analysis cell entry coronavirus Cryo-electron microscopy determine flexible fusion peptide high-resolution structure HKU1 host cells host tropism MERS-CoV MHV Neutralizing antibodies NL63 other coronavirus pathogenic coronavirus pre-fusion Protein Proteins RBD receptor Receptor binding Receptor binding domain reported SARS-CoV SARS-CoV S protein Sequence conservation spike glycoprotein Structure target the RBD trimeric virus [DOI] 10.1038/ncomms15092 PMC 바로가기 [Article Type] Article
SARS-CoV fusion peptides induce membrane surface ordering and curvatureArticle Published on 2016-11-282022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acute respiratory syndrome anionic changes in coronavirus CoV domain ESR fusion peptide generate helping Hypothesis induce information interactions involved kinetic mechanism membrane membrane fusion membranes molecular overcome peptide phospholipid promoted reduce S2 subunit SARS-CoV spike glycoprotein Stage Support triggered Vesicle virus entry [DOI] 10.1038/srep37131 PMC 바로가기 [Article Type] Article
SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J MiceArticle Published on 2016-06-282022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acute respiratory syndrome antiviral immune response approach Arthritis Autoimmune cartilage chain coronavirus disease dosage Efficacy evade Evidence fusion fusion peptide Host Host immune response hosts Hypothesis immune immunomodulatory in vivo include incorporation increase Infection involved lipoprotein mice modulate molecular mechanism multichain peptide PROTECT receptor replicate SARS-CoV sequence Signaling significantly suggested Support T cell receptor target TCR therapeutic strategy transferred Viral immune evasion virus [DOI] 10.1038/srep28672 PMC 바로가기 [Article Type] Article
Identification of small molecules acting against H1N1 influenza A virusArticle Published on 2016-01-152023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] Diverse library fusion peptide hemagglutinin Hemolysis Influenza [DOI] 10.1016/j.virol.2015.11.024
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent MannerResearch Article Published on 2014-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Cell cell entry Clathrin-mediated endocytosis cleavage conformational change coronavirus CoV CoVs demonstrated endocytosed endosomal maturation endosomal pH entry pathway expressing furin furin cleavage site fusion fusion peptide fusion protein gene silencing Genome Host host cell host cell membrane induce Infection influenza A virus inhibited introduced investigated late endosomes less lysosomal protease lysosomal proteases lysosome membrane fusion MERS MERS-CoV MHV microenvironment mouse hepatitis murine hepatitis virus negatively affected occur pathogen plasma membrane predicted previous study promote protease Protease inhibitor Protein proteolytic cleavage Proteolytic processing reporter required S protein shown siRNA Specific the S protein upstream vesicular stomatitis virus virus while zoonotic [DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article