A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries국가별 SARS-CoV-2 및 그 변이체 오미크론에 대한 포괄적인 게놈 연구, 돌연변이 스크리닝, 계통 발생 및 통계 분석Article Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anticipated approach assist average B.1.1.529 B.1.617.2 bioinformatics Brazil changes in Complete confidence conserved Corona coronavirus country COVID-19 Delta determined by domain domains Drug discovery Effect evaluate Evolution full-length genome Genes genetic diversity Genome genome sequence Genome sequences genomic genomic sequence help heterozygosity highest identify in viral in-silico information isolates Japan MSN Mutation mutation analysis offer omicron Omicron variant Omicron variants ORF1 ORF10 ORF1ab ORF7a Phylogenetic Phylogenetic tree Phylogeny polymorphism Population predict prevalent Protein provide resource SARS-CoV-2 selected sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape Spike protein standard error statistical analysis strain the Spike the vaccine these viruses TRS unique Vaccine variant variants Variation variations viral genome viral genome sequence viruses was determined was used were used Wuhan-Hu-1 [DOI] 10.1016/j.jiph.2022.07.002 PMC 바로가기 [Article Type] Article
Chromosomal-level reference genome assembly of the North American wolverine (Gulo gulo luscus): a resource for conservation genomics북미 울버린(Gulo gulo luscus)의 염색체 수준 참조 게놈 어셈블리: 보존 유전체학을 위한 리소스Article Published on 2022-07-292022-09-11 Journal: G3 (Bethesda, Md.) [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 aggression aggression genes aggressive behavior baseline Canada chromosomal-level assembly Climate change Complete conservation genomics contig coronavirus Coronavirus-2 Coronaviruses environmental disruption Final Genes Genetic Genome genome assembly genomes Gulo gulo Gulo gulo luscus heterozygous Infection innate immune system Innate immunity involved long-reads male management modality naïve North nucleotide Nunavut parasitic diseases Pathogens reference genome resource SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Single nucleotide variant specimen Support susceptibility viral pathogen viral pathogens wolverine wolverine. [DOI] 10.1093/g3journal/jkac138 PMC 바로가기 [Article Type] Article
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article
DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndromeDecodeME: 근육통 뇌척수염/만성 피로 증후군의 대규모 유전학 연구를 위한 커뮤니티 모집Article Published on 2022-07-192022-09-11 Journal: BMC Neurology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] aetiology approach association causes cell type cell types cellular processe cellular processes Chronic fatigue chronic fatigue syndrome Clinical diagnosis Co-production Community contributing to controls criteria diagnose Diagnosis diagnostic diagnostic test digital marketing disease DNA effective effective therapy eligible Encephalomyelitis ethics committee fatigue fatigue syndrome funding generate Genes genetic data genetics Genome-wide association study genomic Genotype hypothese hypotheses identification IMPROVE include individuals International intervals Involvement knowledge lack malaise mechanism media myalgic encephalomyelitis North Open Access paper participant Participation Patient and Public Involvement. Public Questionnaires recruitment Relieved by reported Research Ethics Result risk Saliva SARS-COV-2 infection significantly social media Treatment UK biobank variant website West [DOI] 10.1186/s12883-022-02763-6 PMC 바로가기 [Article Type] Article
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsCOVID-19 환자의 중증도를 뒷받침하는 혈액 RNA 숙주 반응의 특성화Article Published on 2022-07-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료법, [키워드] abundance addition Administered Alter Analysis asymptomatic infection biological processe biological processes Blood blood transcriptome clinical manifestations COVID-19 patient COVID-19 severity differential expression Differential expression analysis disease dysregulation Genes groups highlight host response immune dysregulation Immunoglobulin immunomodulatory Increasing individual Infection inflammatory immune response life-threatening macrophages Mild moderate neutrophil Neutrophils offer Pairwise comparison pairwise comparisons Pathway enrichment analysis Pathways performed progression Research RNA SARS-CoV-2 severe COVID-19 severe disease severity Transcriptome Treatment unique upregulation Whole blood Whole blood transcriptomics [DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article
Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina아르헨티나 코르도바에서 생존자와 비생존자 COVID-19 환자의 SARS-CoV-2 계통발생 분석 및 비교 유전체학Article Published on 2022-07-142022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association B.1 both groups carried Clinical characteristics Clinical outcome clinical outcomes Comorbidities Comorbidity Comparative Comparative genomics Complete Córdoba coronavirus cough COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 patients Dyspnea Epidemiological study Evolution Evolution of SARS-CoV-2 Fever First wave functional Future Genes genome sequence Genome sequences genomes Genomic analysis genomic data groups Hospitalization in both groups incidence Infectious diseases Lineage majority Molecular epidemiology Mutation nasopharyngeal specimen Next-generation sequencing nine non-survivor Non-survivors Nsp3 outcomes pandemic Patient patients performed phylodynamic Prevalence Protein repertoire Research respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation SARS-CoV-2 pathogenesis SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South America Specific specific mutation specific mutations Spike protein Spread survivor Survivors Symptom Symptoms the SARS-CoV-2 the Spike variant Variation was performed [DOI] 10.1186/s12864-022-08756-6 PMC 바로가기 [Article Type] Article
Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland샘에서 바이러스 검출과 독립적으로 COVID-19로 사망한 피험자의 뇌하수체 호르몬 유전자 억제Article Published on 2022-07-142022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACTH adrenocorticotropic adrenocorticotropic hormone Antigen antigens cardiac death Cell Chain Reaction changes in clinically controls COVID-19 COVID-19 case COVID-19 group cytotoxic cell death deficiency detection died direct viral infection dysfunction evaluate exploration expression Gene Expression Genes gland hormone Hormones hospitalized patients hypophysis immune immunohistochemistry In situ hybridization investigated Involvement Level mRNA transcript mRNA transcripts neurohypophysis neutrophil Patient PCR Pituitary pituitary apoplexy pituitary gland pituitary hormone pituitary hormones. polymerase chain polymerase chain reaction Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection searched serum severe COVID-19 Signaling subject sudden cardiac death suggested Support suppressed suppression the SARS-CoV-2 genome transmission electron microscopy trauma tropism tropism of SARS-CoV-2 type I interferon Viral viral genome viral infection virus were measured [DOI] 10.1210/clinem/dgac312 PMC 바로가기 [Article Type] Article
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ωSARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type III up-regulated [DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article
mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primatesmRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA [DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article