The Human Pangenome Project: a global resource to map genomic diversity Reviews Published on 2022-04-202022-10-05 Journal: Nature [Category] 유전자 메커니즘, [키워드] Analysis association Biomedical research Complete diploid elements expand functional Genetic Genome genomes genomic genomic variation Haplotype Human Human genetics human reference genome IMPROVE linear populations Precision reference Region Research resource sequence single-nucleotide Streamline Structural variant Study design variants [DOI] 10.1038/s41586-022-04601-8 [Article Type] Reviews
Early Emergence Phase of SARS-CoV-2 Delta Variant in Florida, US미국 플로리다에서 SARS-CoV-2 델타 변종 초기 출현 단계Article Published on 2022-04-062022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Asia B.1.617.2 benefit causative agent clade contagious COVID-19 Delta delta variant demonstrated dominant lineage early emergence effort emergence Epidemic Epidemiology Europe FIVE Florida genomes genomic Genomic analysis independent India Local MONITOR North America pandemic phase Phylogenetic analysis prevalent Public health responses SARS-CoV-2 Spread subsequent Substitution Support Surveillance Transmission Transmission dynamics understanding variant variants VoC [DOI] 10.3390/v14040766 PMC 바로가기 [Article Type] Article
Identification of Genetic Risk Factors of Severe COVID-19 Using Extensive Phenotypic Data: A Proof-of-Concept Study in a Cohort of Russian Patients광범위한 표현형 데이터를 사용한 심각한 COVID-19의 유전적 위험 요인 식별: 러시아 환자 집단에서 개념 증명 연구Article Published on 2022-03-172022-09-11 Journal: Genes [Category] 변종, [키워드] Analysis association ATXN1 binary trait breadth candidate gene CDH23 circumvent Cohort cohort of patients cohorts conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity deep phenotyping disease severity Extensive Factor Genetic genetic associations genetic risk factor genetic risk factors Genetic variant genetic variants genome coverage genomes GWAS Hospitalization Host identification identify independent Interaction loci MYH14 NGS outcome over pathogen predict Quantitative quantitative trait quantitative traits replicated researcher risk Russia SCN11A SETX severe COVID-19 severity the disease UK Biobank data utility variant variants variety while [DOI] 10.3390/genes13030534 PMC 바로가기 [Article Type] Article
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSARS-CoV-2 게놈에서 CpG 고갈의 둔화 속도는 인간 숙주에 대한 적응과 일치합니다Discoveries Published on 2022-03-032022-09-10 Journal: Molecular Biology and Evolution [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation alpha- analyzed Antiviral antiviral protein Beta coding regions codon positions Coronavirus-2 CpG CpG depletion Depletion dinucleotide driven by equilibrium Evidence Evolution full-length SARS-CoV-2 genome Genome genomes help highest highlight Host Human human host immune immune responses Infection innate immune responses Loss majority motif motifs occur pandemic Rate reduced representing respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes selection pressure sequence sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Temporal temporal variation TLR7 variants of concern Variation variations virus Virus evolution virus genome virus genomes virus replication ZAP ZAP-binding motif Zinc [DOI] 10.1093/molbev/msac029 PMC 바로가기 [Article Type] Discoveries
Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease유전형-표현형 상관관계가 심각한 질병과 관련될 수 있는 새로운 SARS-CoV-2 변이를 확인했습니다Article Published on 2022-03-012022-09-11 Journal: Transboundary and emerging diseases [Category] MERS, SARS, 변종, 진단, [키워드] Adults age analysed Asia carried Clinical data Cluster Clustering conditions correlation COVID-19 COVID-19 patient D614G mutation database Diabetic diabetic patient diabetic patients disease severity Dubai Europe European Evidence First wave Fisher Fisher's exact test genomes geographic location Health healthy heterogeneous higher infectivity highlight hospital Hospital admission Hospitalized ICU independent India intensive care Iran laboratory-confirmed majority medical record medical records Mild Missense moderate disease molecular Molecular epidemiology molecular phylogeny Mortality Mutation N proteins Nasopharyngeal swab nasopharyngeal swab PCR nasopharyngeal swabs obese Older age outbreak overweight overweight/obese Patient positive Q271R SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 variant selected sequenced Sequencing sequencing data severe COVID-19 severe disease Sex significantly strain synonymous Test Transmission unique United Arab Emirates Viral viral strain viral strains whole genome Whole genome sequencing women [DOI] 10.1111/tbed.14004 PMC 바로가기 [Article Type] Article
Analysis of Genomic Characteristics of SARS-CoV-2 in Italy, 29 January to 27 March 20202020년 1월 29일부터 3월 27일까지 이탈리아에서 SARS-CoV-2의 게놈 특성 분석Article Published on 2022-02-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis authors B.1 center circulation collected Continuous dated phylogeny descendant epidemiological data Evolution Evolutionary rate gene flow gene flows Genome genomes Genomics highest HPD interval investigated Italian regions Italy lineage B.1 lineages majority molecular Next-generation sequencing NGS North O -glycosylation occurred performed Phylogenetic analysis Phylogeny reported SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage South Spread suggested Surveillance virus [DOI] 10.3390/v14030472 PMC 바로가기 [Article Type] Article
Genomic Bootstrap Barcodes and Their Application to Study the Evolution of SarbecovirusesArticle Published on 2022-02-212022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] addition Analysis ancestor appear application applied Asia barcode bat bootstrap complicate composed Consensus coronavirus COVID-19 origin COVID-19 pandemic described event Evidence generate Genome genomes genomic genomic region group hidden highlight include Lineage mechanism Phylogenetic phylogenetic support RaTG13 Recombination recombination event Region Reservoir host responsible RmYN02 RNA RNA recombination RNA-dependent RNA polymerase Sarbecoviruses SARS-CoV SARS-CoV-2 supported the SARS epidemic tree reconstruction viral circRNA virus [DOI] 10.3390/v14020440 PMC 바로가기 [Article Type] Article
High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein스파이크 단백질을 넘어 SARS-CoV-2의 게놈 전체 분석에 의해 밝혀진 국가 간 Delta 변이체의 높은 다양성Article Published on 2022-02-142022-09-10 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha variant Amino acid Analysis Beta Bioinformatics analysis contagious coronavirus country Delta delta variant dominant feature focus genomes highlight identify life list Microbiology, Virology & Host Pathogen Interaction Missense mutation Mutation mutations neutralization nucleocapsid other variant other variants pathogenic performed Prevalence prevalent prevalent strain Protein Proteins proteome public health reduced SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 genomes SARS‐CoV‐2 protein SARS‐CoV‐2 proteins SARS‐CoV‐2 spike Spike protein susceptibility systematic analysis the Spike Transmissibility Vaccines Viral viral loads while [DOI] 10.15252/msb.202110673 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 Variants From 24,181 Patients Exemplifies the Role of Globalization and Zoonosis in PandemicsMicrobiology Published on 2022-02-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition classification collected combating country COVID-19 death defined described Epidemic epidemic peak Epidemics France Genome genomes genomic Genotype Globalization hallmark incidence infections Intensive introduced Marseille Mortality mutant Mutation Pandemics pangolin Patient patients Prevent qPCR reported Repository role SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant Sequencing Seven Surveillance Transmission Travel variant variants viral genome Viral variants was determined whole genome zoonosis [DOI] 10.3389/fmicb.2021.786233 PMC 바로가기 [Article Type] Microbiology